Redox-responsive nanoparticles based on Chondroitin Sulfate and Docetaxel prodrug for tumor targeted delivery of Docetaxel

Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

“…Breast carcinoma [22] GSH-cleavage: Tetrasulfide bond DOX and PD-L1 antibody Breast carcinoma [23] GSH-cleavage: Disulfide-bond Photosensitizer and IDO-1 Breast carcinoma and colorectal cancer [24] GSH-cleavage: Disulfide-bond Photosensitizer and IDO inhibitor Breast carcinoma [25] Redox-sensitive linkage: Diselenide bond PTX Breast carcinoma [26] GSH-cleavage: Disulfide-bond Docetaxel and Chondroitin sulfate Breast carcinoma [27] Enzyme 𝛽-glucuronidase-degradation: Glucuronide Imidazoquinoline TLR7/8 agonist Raw blue reporter cell line [28] HAase-responsive: HA Cilengitide and TNF-related apoptosis inducing ligand Human breast carcinoma [29] Enzyme-degradation: Matrix metalloproteinases peptide TLR7 agonist 1V209 and Cy 5.5 dye Breast carcinoma [30] Enzyme responsive: Gly-phe-leu-gly tetrapeptide linker DOX Breast carcinoma [31] Enzyme-degradation: Matrix metalloproteinases peptide PD-L1 inhibitor and DOX Melanoma [32] Enzyme-responsive: Polytyrosine DOX Colorectal carcinoma [33] ROS H 2 O 2 -reaction: MnO 2 Gold-photosensitizer and MnO 2 Breast carcinoma [34] ROS-trigger: Tellurium nanowire Bovine serum albumin and dextran Breast carcinoma [35] H 2 O 2 -reaction: MnO 2 Glycolysis inhibitor and lactate oxidase Melanoma [36] H 2 O 2 -reaction: MnO 2 Acriflavine Breast carcinoma [37] ROS-cleavage: Thioketal bond CPT, photosensitizer, and Pt Colon cancer [38] ROS-responsive: Thioether PTX and Ce6 Breast carcinoma [39] Photo Photo-responsive: Photosensitizer PpIX PpIX and immune checkpoint inhibitor 1MT…”

Advances in the Application of Nanomaterials to the Treatment of Melanoma

“…Nanoparticles (NPs) can be used to deliver drugs to corresponding targets in the body, thus significantly increasing the concentration of drugs in the target area, improving specificity and therapeutic effect, and reducing the potentially deleterious side effects. Nanoparticle-based drug delivery systems have succeeded tremendously in various tumor-targeted therapies [ 19 , 20 ]. In addition, multifunctional NPs can improve drug stability and control drug release, thereby reducing dosing frequency.…”

Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy

“…Although TPP-conjugated derivatives possess both mitochondrial targeting and mitochondrial damaging functions just like TPP, those lipophilic cation derivatives could be eliminated in blood quickly ( Khatun et al, 2017 ; Liu et al, 2018 ; Song et al, 2018 ). Chondroitin sulfate (CS), as an anionic and a CD44 acceptor, can be employed to modify nanoparticles, and this can prolong blood circulation as well as endow an active targeting ability to the cell membrane ( Liu M. et al, 2018 ; Lee et al, 2020 ; Li et al, 2021 ). Herein, Zhang et al (2020) developed pH/redox dual-sensitive, mitochondria/cell membrane synergic targeting nanomicelles for mitochondrial targeted therapy.…”