Stimuli-responsive polymeric micelles, a novel category of polymeric micelles with response to endogenous or exogenous environments, show variable physicochemical properties as the variation of endogenous or exogenous circumstances. Because of differences between tumour tissues and normal tissues in physicochemical properties and sensitivity to variation of endogenous or exogenous environments, the application of chemotherapeutic agents loaded stimuli-responsive polymeric micelles are regarded as promising strategies for tumour treatment. In this article, the recent developments of chemotherapeutic agents loaded stimuli-responsive polymeric micelles, for example the preparation of novel stimuli-responsive polymeric micelles and the research progresses of action mechanisms of chemotherapeutic agents loaded micelles, were reviewed and discussed in detail. The advantages of stimuli-responsive chemotherapeutic agents loaded polymeric micelles in practical tumour treatment were also illustrated with the assistance of examples of stimuli-responsive polymeric micelles for antitumor agents delivery.

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An annular-shaped high-power nitrogen microwave-induced generated by use of an Okamoto cavity. To the knowledge of the present workers, no papers have been published on the appli-plasma (N 2 -MIP) produced at atmospheric pressure by an Okamoto cavity has been used as a new excitation source for cation of high-power N 2 -MIP-AES to the analysis of real samples. The present paper describes the feasibility of using a high-the determination of trace amounts of Sb in pure copper by hydride generation atomic emission spectrometry (AES).power N 2 -MIP for AES for the determination of Sb in combination with both conventional solution nebulization and a Under the optimized experimental conditions, the best attainable detection limit at the Sb I 217.581 nm line by use of hydride generation system. The results obtained by both sample introduction methods are compared in terms of analytical figures N 2 -MIP-AES coupled with hydride generation was 4.46 ng ml−1 of Sb with a linear dynamic range of of merit for Sb. Finally, after an interference study, the proposed method coupled with hydride generation was successfully applied 50-5000 ng ml−1 of Sb. The presence of several diverse elements was found to cause a depressing interference on the to the determination of total concentrations of Sb in samples of high-purity copper metals. determination of Sb using the present technique. Of several pre-reductants examined, thiourea was found to be the most preferable to reduce SbV to SbIII prior to hydride generation EXPERIMENTAL for the determination of total Sb i.e., SbIII+SbV. The present Instrumentation and apparatus method using thiourea not only as a pre-reductant but also as an interference-releasing agent was applied to the A schematic diagram of the experimental apparatus is shown determination of low concentrations of Sb in samples of highin Fig. 1. Microwave power is transferred from a magnetron purity copper metals. The results obtained by this method were(2.45 GHz, 1 kW) of a Nippon Koushuha MKN-103-3S microin good agreement with the reference values.wave power generator to the discharge tube (torch) through a uniline, directional coupler, three-stub tuner, tapered wave-Keywords: High-power nitrogen microwave-induced plasma;guide and an Okamoto cavity, the details of which have Okamoto cavity; atomic emission spectrometry; hydride already been described in the literature.11-14 A high-power N 2 generation; antimony; high-purity copper metals MIP source together with a magnetron was mounted on a laboratory-made optical rail for x-y-z direction adjustments. It is well known that the MIP has become a powerful source of An annular-shaped (toroidal ) plasma is formed above the excitation and ionization, enabling not only the determination of quartz torch. The computer-controlled sequential spectrometer metals but also of many nonmetals. However, an MIP such as used in this work was a part of a Nippon Jarrell-Ash ICAP-575 the one produced by either a Beenakker cavity1-6 or a II inductively coupled plasma emission spectrometer. Th...