Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression

Cooper, Jessica A.; Nuutinen, Makiah; Lawlor, Victoria M.; DeVries, Brittany; Barrick, Elyssa M.; Hossein, Shabnam; Cole, Daniel J.; Leonard, Chelsea; Hahn, Emma; Teer, Andrew P.; Shields, Grant S.; Slavich, George M.; Öngür, Döst; Jensen, J. Eric; Du, Fei; Pizzagalli, Diego A.; Treadway, Michael T.

doi:10.1038/s41467-021-23284-9

Cited by 22 publications

(11 citation statements)

References 67 publications

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“…Moreover, patients with higher depression scores in the HADS‐D reported more intensive stress in the period preceding the operation, which is in line with the results of the study, stating that people with depression have worse biochemical mechanisms to deal with stress (Cooper et al, 2021). Those with higher anxiety scores in the HADS‐A reported feeling more nervous both before and during the surgery, which is not surprising as stress and anxiety are strongly interconnected in behavioural and nervous context (Daviu et al, 2019).…”

Section: Discussionsupporting

confidence: 86%

What helps patients to prepare for and cope during awake craniotomy? A prospective qualitative study

Bala

Olejnik

Dziedzic

et al. 2023

Journal of Neuropsychology

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There is growing interest in awake craniotomies, but some clinicians are concerned that such procedures are poorly tolerated by patients. Therefore, we conducted a study to assess this phenomenon. In this prospective qualitative study, 68 patients who qualified for awake craniotomy were asked to complete the Hospital Anxiety and Depression Scale (HADS)—two days before the surgery and visual analogue scales (VAS) for pain and stress, two days before the surgery and again about two days after. In addition, after their surgery, they took part in a structured interview about what helped them prepare for and cope with the surgery. Most patients tolerated the awake surgery well, scoring low on stress and pain scales. They reported a lower level of stress during the surgery (when questioned afterwards) than before it. Intensity of stress before the surgery correlated negatively with age, positively with HADS anxiety score and positively with stress subsequently experienced during surgery. The level of stress during surgery was associated with stress experienced before the surgery, pain and HADS anxiety and depression scores. Severity of pain during the surgery was positively correlated with stress during surgery and HADS depression and anxiety scores before the surgery. There was no correlation between stress, pain, anxiety and depression and the location of the lesion. Patients have a high tolerance for awake craniotomy. Various factors have an impact on how well patients cope with the operation. Extensive preoperative preparation should be considered a key part of the procedure.

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Section: Discussionsupporting

confidence: 86%

What helps patients to prepare for and cope during awake craniotomy? A prospective qualitative study

Bala

Olejnik

Dziedzic

et al. 2023

Journal of Neuropsychology

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“…In a Bayesian, decision-theoretic account, depression entails pessimistic expectations about the value of future rewards and possible actions (Huys et al, 2015), an observation well supported by evidence (Cooper et al, 2021). As noted above, Panksepp emphasized the role of the SEEKING system in anticipation of positive outcomes rather than in ongoing hedonic experience, and he viewed hypoactivity of the system as a determinant of depression (Panksepp and Yovell, 2014).…”

Section: Anhedonia In Depressionmentioning

confidence: 91%

“…Presumably, the antidromic action potentials could invade cortical collaterals that drive local inhibitory interneurons. That proposal is of particular interest given a recent report linking maladaptive stress-induced glutamatergic responses in the medial prefrontal cortex in depressed patients to pessimistic expectations (Cooper et al, 2021). That said, the report from the Freiburg group emphasizes orbitofrontal efferents, rather than medial prefrontal ones.…”

Section: The Centrality Of the Dopamine Neurons?mentioning

confidence: 99%

The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle

Pallikaras

Shizgal

2022

Front. Behav. Neurosci.

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Deep-brain stimulation of the medial forebrain bundle (MFB) can provide effective, enduring relief of treatment-resistant depression. Panksepp provided an explanatory framework: the MFB constitutes the core of the neural circuitry subserving the anticipation and pursuit of rewards: the “SEEKING” system. On that view, the SEEKING system is hypoactive in depressed individuals; background electrical stimulation of the MFB alleviates symptoms by normalizing activity. Panksepp attributed intracranial self-stimulation to excitation of the SEEKING system in which the ascending projections of midbrain dopamine neurons are an essential component. In parallel with Panksepp’s qualitative work, intracranial self-stimulation has long been studied quantitatively by psychophysical means. That work argues that the predominant directly stimulated substrate for MFB self-stimulation are myelinated, non-dopaminergic fibers, more readily excited by brief electrical current pulses than the thin, unmyelinated axons of the midbrain dopamine neurons. The series-circuit hypothesis reconciles this view with the evidence implicating dopamine in MFB self-stimulation as follows: direct activation of myelinated MFB fibers is rewarding due to their trans-synaptic activation of midbrain dopamine neurons. A recent study in which rats worked for optogenetic stimulation of midbrain dopamine neurons challenges the series-circuit hypothesis and provides a new model of intracranial self-stimulation in which the myelinated non-dopaminergic neurons and the midbrain dopamine projections access the behavioral final common path for reward seeking via separate, converging routes. We explore the potential implications of this convergence model for the interpretation of the antidepressant effect of MFB stimulation. We also discuss the consistent finding that psychomotor stimulants, which boost dopaminergic neurotransmission, fail to provide a monotherapy for depression. We propose that non-dopaminergic MFB components may contribute to the therapeutic effect in parallel to, in synergy with, or even instead of, a dopaminergic component.

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“…[33] In a sample of patients with this disorder, glutamatergic adaptation to stress was also characteristically impaired. [34]…”

Section: Brain Structures Neuroendocrinology and Stressmentioning

confidence: 99%

Mental health and validity of the psycho-neurobiological stress model

2022

AJPRR

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Background and objectives: The public costs of self-reported mental stress and distress are enormous. And both the advance of neurobiology and the modern more biological approach of psychiatry as a whole are considerable. This work intends to provide an essential, updated and objective panoramic view on the neurobiology of all kinds of stress in relation to people’s mental health and pathologies. Method: Bibliographic indexes such as Pubmed, Psycinfo Journal and Índices CSIC, were consulted, among others. The matter being tackled is extremely profuse, varied and complex, therefore the found literature has been as numerous as heterogeneous. It is also so dispersed that we have conducted a narrative non-systematic review that is intended to be impartial and balanced. Results: This article will concisely discuss the available, prominent and reliable scientific information regarding the main cerebral structures involved in the experience of stress, such as the hippocampus, prefrontal cortex, amygdala and hypothalamus. It will also comment on stress physiology, neuroendocrinology and associated psychopathology, as well as specifically certain genetic variations and linked molecular and immune activities. Conclusion: We have synthesised the relevant and current scientific knowledge of the correlations among stress, mental health and neurobiology as well as of their reciprocal interactions. There is increasing knowledge of these correlations and interactions, but it remains limited. Accordingly, further research is required.

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Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression

Cited by 22 publications

References 67 publications

What helps patients to prepare for and cope during awake craniotomy? A prospective qualitative study

What helps patients to prepare for and cope during awake craniotomy? A prospective qualitative study

The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle

Mental health and validity of the psycho-neurobiological stress model

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