This paper considers an adaptive fault-tolerant control problem for a class of uncertain strict feedback nonlinear systems, in which the actuator has an unknown drift fault and the loss of effectiveness fault. Based on the event-triggered theory, the adaptive backstepping technique, and Lyapunov theory, a novel fault-tolerant control strategy is presented. It is shown that an appropriate comprise between the control performance and the sensor data real-time transmission consumption is made, and the fault-tolerant tracking control problem of the strict feedback nonlinear system with uncertain and unknown control direction is solved. The adaptive backstepping method is introduced to compensate the actuator faults. Moreover, a new adjustable event-triggered rule is designed to determine the sampling state instants. The overall control strategy guarantees that the output signal tracks the reference signal, and all the signals of the closed-loop systems are convergent. Finally, the fan speed control system is constructed to demonstrate the validity of the proposed strategy and the application of the general systems.