Reduced Amounts of Pyroglutamic Acid in Scales From Psoriatic Plaques

Marstein, Sverre

doi:10.1001/archderm.1973.01620250058022

Cited by 8 publications

(1 citation statement)

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“…Main cause of psoriasis may be due to faulty signals in the immune system, which results in the formation of new skin cells in days rather than in weeks. When the body does not shed these excess cells, they pile up on the surface of the skin and lesions may form [4][5][6]. However, the psoriasis is not a contagious disease.…”

Section: Introductionmentioning

confidence: 99%

GC Analysis of Amino Acids Using Trifluoroacetylacetone and Ethyl Chloroformate as Derivatizing Reagents in Skin Samples of Psoriatic and Arsenicosis Patients

Khuhawar

Majidano

2011

Chromatographia

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The separation and determination of 19 amino acids were examined using two stages derivatization with trifluoroacetylacetone and ethyl chloroformate from the column HP-5 (30 m 9 0.32 mm id) with film thickness 0.25 lm at an initial column temperature 100°C for 2 min with ramping of 20°C min -1 up to 250°C with nitrogen flow rate of 3 mL min -1 . The detection was performed by flame ionization detector. Total separation time was 10 min. The separation was repeatable with relative standard deviation (RSD) (n = 5) within 1.5-1.9 and 1.3-1.7% in terms of retention time and peak height/peak area, respectively. The method was applied for the determination of amino acids from skin samples of psoriatic patients (n = 6), arsenicosis patients (n = 5) and normal subjects (n = 9) and variation in the contents of the amino acids was noted. The RSDs for the determination were obtained within 3%.

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Section: Introductionmentioning

confidence: 99%