Reduced auditory P300 amplitude, medial temporal volume reduction and psychopathology in schizophrenia

Kawasaki, Yasuhiro; Matsuo, Yoshiki; Higashima, Masato; Nagasawa, T.; Koshino, Yoshifumi; Suzuki, Masayuki; Ide, Yoshihiko

doi:10.1016/s0920-9964(97)00055-8

Cited by 52 publications

(20 citation statements)

References 35 publications

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“…However, there are studies that contradict these findings, showing that correlations between volumes of temporal lobe structures and left P300 amplitudes are low and not significant (Havermans et al, 1999;Meisenzahl et al, 2004). Our findings provide support to the studies by Light et al (2012), Turetsky et al (2009), McCarley et al (1993, 2002) Kawasaki et al, (1997) and Preuss et al, (2010).…”

Section: Discussionsupporting

confidence: 84%

“…Our electrophysiological findings parallel those from patients with schizophrenia, in which decreases in N100 amplitude have been reported (Turetsky et al, 2009;Light et al, 2012). These findings are compelling because there are intriguing reports in the literature about an anatomicphysiological correlate in schizophrenic patients in which a reduction in the amplitude of the P300 response is correlated with a reduction in the volume of the left posterior superior temporal gyrus (McCarley et al, 1993;2002), the anterior medial temporal cortex (Kawasaki et al, 1997) and the anterior cingulate cortex (Preuss et al, 2010). However, there are studies that contradict these findings, showing that correlations between volumes of temporal lobe structures and left P300 amplitudes are low and not significant (Havermans et al, 1999;Meisenzahl et al, 2004).…”

Section: Discussionsupporting

confidence: 84%

See 1 more Smart Citation

Histological correlates of N40 auditory evoked potentials in adult rats after neonatal ventral hippocampal lesion: animal model of schizophrenia

Romero-Pimentel

Vázquez-Roque

Camacho-Ábrego

et al. 2014

Schizophrenia Research

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Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 84%

Histological correlates of N40 auditory evoked potentials in adult rats after neonatal ventral hippocampal lesion: animal model of schizophrenia

Romero-Pimentel

Vázquez-Roque

Camacho-Ábrego

et al. 2014

Schizophrenia Research

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“…Our recent study reported that a reduced P300 amplitude is associated with volume reduction of the left medial temporal lobe in schizophrenia (Kawasaki 1997), and many reports suggest that part of P300 recorded on the scalp generates from the medial temporal lobe (Okada, 1983). The present study could not determine which region of the temporal lobe, however, becomes a pathologic focus for P300 and neuropsychological abnormalities in schizophrenia.…”

Section: Discussioncontrasting

confidence: 65%

The relationship between auditory ERP and neuropsychological assessments in schizophrenia☆

Nagasawa¹,

Kamiya²,

Kawasaki³

et al. 1999

International Journal of Psychophysiology

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To clarify the cognitive significance of event-related potential (ERP) abnormalities in schizophrenia, we examined the relationships of amplitudes and latencies of ERP components with performance on neuropsyhological tests in schizophrenic patients. Twenty patients underwent the Trail Making B Test (TM-B), which is sensitive to frontal lobe dysfunction, and the logical memory, verbal paired-association, and visual reproduction subtests of the Wechsler Memory Scale (WMS), which are sensitive to temporal lobe dysfunctions, and ERP recordings during performance of an oddball auditory discrimination task. Pearson product-moment correlations indicated that an increased P200 amplitude was correlated with poor performance on the TM-B, whereas a decreased P300 amplitude was correlated with poor performance on the verbal paired-association subtest of the WMS. These findings suggest that a P200 abnormality represents the frontal lobe dysfunction, and a P300 abnormality represents the left temporal lobe dysfunction in schizophrenia.

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“…A reduced medial temporal lobe volume was found to be associated with more severe clinical symptoms [38]. However, in our study, being a medial temporal lobe structure, the size of the hippocampus was not related with clinical symptoms, but a reduced hippocampal volume was also associated with poor treatment response.…”

Section: Discussioncontrasting

confidence: 82%

Hippocampal Volume in Schizophrenia and Its Relationship with Risperidone Treatment: A Stereological Study

Savaş¹,

Ünal

Erbaǧcı

et al. 2002

Neuropsychobiology

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The purpose of this study was to assess the significance of the hippocampal volume differences and its relation with risperidone treatment in schizophrenia. In schizophrenic patients who were on risperidone treatment (n = 11) and in healthy volunteers (n = 11), volumes of the hippocampi were estimated using magnetic resonance images (MRIs). A detailed systematic series of coronal MRIs of the entire brain (3 mm thickness, T₁-weighted, TR/TE 400/10 ms) was obtained for each subject. All estimations were done according to Cavalieri’s method by a modified point-counting grid placed on surface areas of hippocampal slices. The mean right and left hippocampal volumes in schizophrenics and control subjects were 1,059.4 and 1,003.2 mm³, and 1,780.1 and 1,589.1 mm³, respectively. The corresponding coefficients of errors were 0.05 and 0.068, and 0.059 and 0.081, respectively. The volumes of left and right hemispheres were not significantly different in both schizophrenic patients and controls (p > 0.05). However, a statistically significant difference (p < 0.05) was found between hippocampal volumes of the schizophrenic patients and controls. In conclusion, the hippocampal volume of the schizophrenic patients is significantly smaller than of the healthy controls. The patients who responded well to risperidone treatment had significantly greater hippocampal volumes than the patients who did not respond properly. Thus, hippocampal volume may be a predictor of the treatment response of schizophrenics to risperidone.

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Reduced auditory P300 amplitude, medial temporal volume reduction and psychopathology in schizophrenia

Cited by 52 publications

References 35 publications

Histological correlates of N40 auditory evoked potentials in adult rats after neonatal ventral hippocampal lesion: animal model of schizophrenia

Histological correlates of N40 auditory evoked potentials in adult rats after neonatal ventral hippocampal lesion: animal model of schizophrenia

The relationship between auditory ERP and neuropsychological assessments in schizophrenia☆

Hippocampal Volume in Schizophrenia and Its Relationship with Risperidone Treatment: A Stereological Study

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