Reduced blood pressure responsiveness to skeletal muscle metaboreflex activation in older adults following inorganic nitrate supplementation

Schneider, Aaron C.; Hughes, William E.; Ueda, Kenichi; Bock, Joshua M.; Casey, Darren P.

doi:10.1016/j.niox.2018.05.010

Cited by 20 publications

(10 citation statements)

References 47 publications

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“…In contrast to static exercise, BRJ has been demonstrated to attenuate BP responses during upper body [ 104 ] and lower-body [ 82 ] dynamic exercise in young adults. Regarding our ischemic stimulus, we found that BRJ did not affect BP responses during PECO, whereas previous work demonstrated BRJ attenuates BP responses during PECO in older adults [ 105 ]. Collectively, these findings suggest that while acute dietary NO 3 − supplementation may reduce CV reactivity in clinical populations and/or older adults, these effects are less pronounced in younger, apparently healthy individuals.…”

Section: Discussioncontrasting

confidence: 55%

Acute beetroot juice reduces blood pressure in young Black and White males but not females

Grosicki¹,

Flatt²,

Cross³

et al. 2023

Redox Biology

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Section: Discussioncontrasting

confidence: 55%

Acute beetroot juice reduces blood pressure in young Black and White males but not females

Grosicki¹,

Flatt²,

Cross³

et al. 2023

Redox Biology

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“…Of the 19 included studies, 12 investigated the effects of nitrates on blood pressure in healthy participants 10–21 and 7 investigated their effects on blood pressure in participants with hypertension. 22–28 The sample size in the healthy population was 500 people aged 18–79 years.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 19 included studies, 12 investigated the effects of nitrates on blood pressure in healthy participants [10][11][12][13][14][15][16][17][18][19][20][21] and 7 investigated their effects on blood pressure in participants…”

Section: Participant Characteristicsmentioning

confidence: 99%

Regulatory effect of dietary nitrate on blood pressure: a meta-analysis of randomized controlled trials

Zhang

et al. 2023

Food Funct.

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“…In the present study, HR was elevated in both OF and YF, and there was no significant difference in ΔHR between the two groups (Figure 2). Therefore, a large increase in MAP during hyperpnoea without a concomitant change in HR in OF implies that larger MAP responses via the metaboreflex are modulated by peripheral vasoconstriction with ageing (Choi et al., 2012; Schneider et al., 2018). Oestrogen has a major effect on the regulation of MAP and vascular tone (Joyner et al., 2016); therefore, oestrogen deficiency might be one reason for the greater MAP response to increased respiratory muscle work in OF.…”

Section: Discussionmentioning

confidence: 99%

Age and sex differences in blood pressure responses during hyperpnoea

Shimizu

Shiozawa

Ishida

et al. 2021

Experimental Physiology

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New Findings What is the central question of this study?Increased respiratory muscle activation is associated with neural and cardiovascular consequences via the respiratory muscle‐induced metaboreflex. Does ageing and/or sex influence the arterial blood pressure response during voluntary normocapnic incremental hyperpnoea? What is the main finding and its importance?The increase in blood pressure during hyperpnoea was smaller in younger females than in older females, whereas no difference was found between older males and older females. The blunted respiratory muscle‐induced metaboreflex in younger females is normalized with advancing age, whereas ageing has no such effect in males. Abstract We hypothesized that older females (OF) have a greater arterial blood pressure response to increased respiratory muscle work compared with younger females (YF) and that no such difference exists between older males (OM) and younger males (YM). To test these hypotheses, cardiovascular responses during voluntary normocapnic incremental hyperpnoea were evaluated and compared between older and younger subjects. An incremental respiratory endurance test (IRET) was performed as follows: target minute ventilation was initially set at 30% of the maximal voluntary ventilation (MVV12) and was increased by 10% of MVV12 every 3 min. The test was terminated when the subject could not maintain the target percentage of MVV12. Heart rate and mean arterial blood pressure (MAP) were recorded continuously. The increase in MAP from baseline (ΔMAP) during the IRET in OM (+24.0 ± 14.7 mmHg, mean ± SD) did not differ (P = 0.144) from that in YM (+24.3 ± 13.4 mmHg), but it was greater (P = 0.004) in OF (+31.2 ± 11.6 mmHg) than in YF (+10.3 ± 5.5 mmHg). No significant difference in ΔMAP during the IRET was observed between OM and OF (P = 0.975). These results suggest that the respiratory muscle‐induced metaboreflex is blunted in YF, but it could be normalized with advancing age. In males, ageing has little effect on the respiratory muscle‐induced metaboreflex. These results show no sex difference in the respiratory muscle‐induced metaboreflex in older adults.

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Reduced blood pressure responsiveness to skeletal muscle metaboreflex activation in older adults following inorganic nitrate supplementation

Cited by 20 publications

References 47 publications

Acute beetroot juice reduces blood pressure in young Black and White males but not females

Acute beetroot juice reduces blood pressure in young Black and White males but not females

Regulatory effect of dietary nitrate on blood pressure: a meta-analysis of randomized controlled trials

Age and sex differences in blood pressure responses during hyperpnoea

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