2014
DOI: 10.1682/jrrd.2014.04.0095
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Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury

Abstract: Abstract-Traumatic brain injury (TBI) can affect bone by influencing the production/actions of pituitary hormones and neuropeptides that play significant regulatory roles in bone metabolism. Previously, we demonstrated that experimental TBI exerted a negative effect on the skeleton. Since mild TBI (mTBI) accounts for the majority of TBI cases, this study was undertaken to evaluate TBI effects using a milder impact model in female mice. Repetitive mTBI caused microhemorrhaging, astrocytosis, and increased anti-… Show more

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Cited by 12 publications
(11 citation statements)
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“…As a measure of astroglial activation in human mTBI, GFAP has been shown to be a sensitive and specific marker of injury (Papa et al, ). GFAP was commonly assessed in the animal studies of this review, and demonstrated utility in detecting injury either via mRNA expression (Yu, Wergedal, Rundle, & Mohan, ), protein levels in the brain (Fehily et al, ; Viano et al, ), or in serum (Candy et al, ). Production of inflammatory cytokines is also linked with glial cell activation following injury, and was commonly assessed in these studies.…”
Section: Discussionmentioning
confidence: 99%
“…As a measure of astroglial activation in human mTBI, GFAP has been shown to be a sensitive and specific marker of injury (Papa et al, ). GFAP was commonly assessed in the animal studies of this review, and demonstrated utility in detecting injury either via mRNA expression (Yu, Wergedal, Rundle, & Mohan, ), protein levels in the brain (Fehily et al, ; Viano et al, ), or in serum (Candy et al, ). Production of inflammatory cytokines is also linked with glial cell activation following injury, and was commonly assessed in these studies.…”
Section: Discussionmentioning
confidence: 99%
“…TBI was induced as previously reported 31,35 . A 75 gram brass weight was used to generate the impact on the skull.…”
Section: Methodsmentioning
confidence: 99%
“…TBI was induced as previously reported. 19 , 20 A 75 g brass weight was used to generate the impact on the skull. To obtain a consistent impact on the mouse skull, a tube was positioned above the mouse calvaria, between the ears.…”
Section: Methodsmentioning
confidence: 99%