In 1992, the nations of earth agreed to "stabilization of greenhouse gas concentrations in the atmosphere at a level that would prevent dangerous anthropogenic interference with the climate system" according to the prescriptions of the United Nations Framework Convention on Climate Change (UNFCCC) (United Nations, 1992). The meaning of "dangerous" was not specifically defined, but it was made clear that action should be taken so as "to allow ecosystems to adapt naturally to climate change, to ensure that food production is not threatened and to enable economic development to proceed in a sustainable manner." Since 1992, the world's nations have continued developing the UNFCCC, and more recently they noted "the importance of averting, minimizing and addressing loss and damage associated with the adverse effects of climate change, including extreme weather events . . ." (United Nations, 2015, p. 26). In doing so, the countries recognized that "adverse effects of climate change" will impose "loss and damage," but they remained silent on the conditions under which such adverse effects, loss, and damage might be considered "dangerous." Such conditions might be reached, for instance, once a certain threshold of damage is achieved or if the rate of increase of loss becomes too high. The nature of those conditions might be different for the viability of the insurance industry, the stability of an economy, the reliability of a food supply, or the steadiness of a political system. Hence, whatever might ultimately be designated as dangerous, it will need to be informed by assessment of impacts around the world and across natural, managed, and human systems. This assessment not only needs to note the global and cross-system averages but also the existence of any localized but transformative impacts, such as might occur around an ice-free Arctic Ocean, as well as disparities in impacts, for instance between wealthy and poor populations. In this chapter we will refer to such an assessment as a synthesis.This chapter is concerned with possibilities and challenges of syntheses that might inform the UNFCCC