Reduced efficacy of ivermectin, abamectin and moxidectin against field isolates of Haemonchus contortus

Wooster, M J; Woodgate, Robert; Chick, B. F.

doi:10.1111/j.1751-0813.2001.tb10932.x

Cited by 26 publications

(12 citation statements)

References 8 publications

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“…A nationwide survey of sheep farms conducted in 2005 showed widespread resistance to commercially available anthelmintics (Waghorn et al 2006), while Leathwick (2004) conducted an analysis that estimated the total discounted cost of anthelmintic resistance accumulated over 30 years (from 2002) would exceed NZ$1.3 billion. Similar reports of anthelmintic resistance have been published in Australia (Wooster et al 2001; Love et al 2003), South Africa (Van Wyk et al 1989, 1999), and the United Kingdom (UK) (Yue et al 2003; Bartley et al 2005; Sargison et al 2007). A trial conducted in the southern sheep-producing zone of Western Australia, in weaned Merinos, estimated that production losses associated with using an ineffective anthelmintic compared with a fully effective one would be >A$2/animal in wool returns and >A$4/animal in animal value over a 12-month period (Besier et al 1996).…”

Section: Introductionsupporting

confidence: 64%

Field efficacy and safety of an oral formulation of the novel combination anthelmintic, derquantel-abamectin, in sheep in New Zealand

Little¹,

Hodge²,

Watson³

et al. 2010

New Zealand Veterinary Journal

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AIM: To evaluate the efficacy and safety of the novel anthelmintic combination, derquantel-abamectin, against gastrointestinal nematode populations in sheep, under field-use conditions.METHODS: Controlled faecal egg count reduction tests (FECRT) were conducted in New Zealand in 14 trials, covering a range of geographic locations, farming enterprises, breeds, nematode populations, and anthelmintic-resistance profiles. Enrolled animals were naturally infected with mixed populations of gastrointestinal nematodes. All trials included a group treated with derquantel-abamectin, and a negative control group. Nine trials included additional groups each treated with a single- or dual-active oral reference anthelmintic, selected from albendazole, levamisole, albendazole-levamisole, ivermectin, abamectin and moxidectin. A total of 838 animals were enrolled across all trials, and were randomly allocated to treatment groups within blocks defined by faecal nematode egg counts (FEC) pre-treatment. On Day 0 derquantel-abamectin was administered orally at 1 ml/5 kg bodyweight (2 mg/kg derquantel, 0.2 mg/ kg abamectin), and each reference anthelmintic was given at the recommended label dose. Faecal samples were collected on Day 14 (± 1 day), to determine the percentage reduction in mean FEC for each anthelmintic tested. Larval differentiation was also performed post-treatment, to estimate efficacy at the genus level. Animals were weighed on or before Day 0, and on Day 14 (± 1 day) in 13 trials.RESULTS: The efficacy of derquantel-abamectin against mixed strongyle populations was ≥99.2%, based on the percentage reduction in geometric mean FEC. Nematodirus sp. was present in six trials at a level sufficient for efficacy calculations to be conducted; in all cases, the efficacy of derquantel-abamectin was 100%. In those trials where the efficacy of at least one reference anthelmintic was <95% against strongyles and/or Nematodirus sp., derquantel-abamectin was 100% effective. In five trials, the mean gain in bodyweight was significantly greater in the derquantel-abamectin group than the negative controls.CONCLUSIONS AND CLINICAL RELEVANCE: When administered orally at 1 ml/5 kg bodyweight, derquantel-abamectin is highly effective for the treatment of gastrointestinal nematodes in sheep, including populations of strongyles and Nematodirus sp. with resistance to one or more single- or dual-active anthelmintics. Derquantel-abamectin presents sheep producers with a unique opportunity to introduce a new class of anthelmintic to their nematode control programmes, with the added benefits offered by a combination anthelmintic.

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Section: Introductionsupporting

confidence: 64%

Field efficacy and safety of an oral formulation of the novel combination anthelmintic, derquantel-abamectin, in sheep in New Zealand

Little¹,

Hodge²,

Watson³

et al. 2010

New Zealand Veterinary Journal

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“…However, moxidectin, by virtue of its potency, is still more than 95% effective against most strains of ML-resistant parasites on sheep farms in Australia, although the persistency of activity against such strains may be reduced. 3 In this paper we report the isolation of multi-drug including ML-resistant Haemonchus contortus from three farms in northern NSW in 2001/2002. One of these isolates is also moxidectin-resistant.…”

mentioning

confidence: 95%

Moxidectin‐resistant Haemonchus contortus in sheep in northern New South Wales

Love¹,

Neilson

Biddle³

et al. 2003

Aust Veterinary J

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“…Infeksi cacing nematoda gastrointestinal merupakan permasalahan kesehatan ternak ruminansia yang penting jika dipandang dari sisi ekonomi (Zvinorova et al, 2016). Infeksi tersebut dapat mengakibatkan depresi, penurunan nafsu makan, gangguan metabolisme protein, energi, mineral, perubahan keseimbangan cairan tubuh, anemia, penurunan pertambahan bobot hidup, peningkatan mortalitas dan gangguan reproduksi (Colley et al, 2001;West et al, 2009;De Graef et al, 2013;Jean et al, 2016a).…”

Section: Kejadian Resistensi Cacing Nematoda Gastrointestinal Terhadaunclassified

Resistensi Cacing Nematoda Gastrointestinal Terhadap Golongan Macrocyclic Lactone pada Ternak Ruminansia

Yanuartono

Indarjulianto

Nururrozi

et al. 2019

JTAPRO

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Cacing nematoda gastrointestinal merupakan parasit yang memiliki peran penting pada ruminansia di negara tropis maupun subtropis. Nematoda tersebut memicu berbagai masalah kesehatan dan dapat mengakibatkan penurunan produksi karena menghambat pertumbuan, rendahnya kenaikan bobot badan, kematian pada hewan muda, biaya pengobatan tinggi dan kerugian ekonomi yang besar dalam usaha peternakan. Penggunaan golongan macrocyclic lactones yang memiliki spektrum luas telah digunakan dalam mengendalikan infeksi cacing nematoda gastrointestinal dalam industri peternakan selama empat dekade yang pada akhirnya menyebabkan resistensi antelmintik. Seiring berkembangnya resistensi terhadap anthelmintik membuat para ahli berusaha mencari metode standar untuk digunakan sebagai deteksi resistensi yang dapat diandalkan. Meskipun demikian, sebagian besar metode yang digunakan memiliki kekurangan seperti biaya tinggi, aplikasi dan interpretasi yang tidak mudah. Saat ini pedoman standar untuk deteksi resistensi anthelmintik telah dikeluarkan oleh World Association for Advancement of Veterinary Parasitology (WAAVP). resistensi antelmintik dapat diatasi atau ditunda dengan berbagai upaya seperti manajemen pencegahan dan pengobatan cacing pada ternak secara terpadu.

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Reduced efficacy of ivermectin, abamectin and moxidectin against field isolates of Haemonchus contortus

Abstract: A reduction in efficacy of abamectin and/or ivermectin against field isolates of H. contortus was identified from two farms in the New England region of New South Wales. The persistent effect of moxidectin was reduced against both isolates.

Cited by 26 publications

References 8 publications

Field efficacy and safety of an oral formulation of the novel combination anthelmintic, derquantel-abamectin, in sheep in New Zealand

Field efficacy and safety of an oral formulation of the novel combination anthelmintic, derquantel-abamectin, in sheep in New Zealand

Moxidectin‐resistant Haemonchus contortus in sheep in northern New South Wales

Resistensi Cacing Nematoda Gastrointestinal Terhadap Golongan Macrocyclic Lactone pada Ternak Ruminansia

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