Reduced Expression of FADS1 Predicts Worse Prognosis in Non-Small-Cell Lung Cancer

Wang, Dong; Lin, Yan; Gao, Bei; Yan, Shumei; Wu, Haoran; Li, Yong; Wu, Qian; Wei, Yucheng

doi:10.7150/jca.15403

Cited by 21 publications

(25 citation statements)

References 29 publications

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“…Table 1 shows that SCD1 is an unfavorable marker of survival in renal and urothelial cancer in TCGA tumors. Other desaturases have also been analyzed as prognostic markers, and, for example, reduced expression of FADS1 suggests pessimistic prognosis for NSCLC patients (127).…”

Section: Fatty Acid-related Alterations As Biomarkers Of Cancer Prognmentioning

confidence: 99%

Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment

2020

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Section: Fatty Acid-related Alterations As Biomarkers Of Cancer Prognmentioning

confidence: 99%

Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment

2020

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“…This stands in opposition to other reports. In other types of tumors, FADS1 and FADS2 exhibit oncogenic properties, for example in non-small-cell lung cancer, where the lower expression of FADS1 is associated with worse prognosis [77]. The oncogenic properties of FADS1 have also been shown in HCA-7 (colon cancer) [78] and BxPC-3 (pancreatic cancer cells) [78].…”

Section: Expression Of Fads1 and Fads2 In Gbm Tumorsmentioning

confidence: 99%

Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme

et al. 2020

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The expression of desaturases is higher in many types of cancer, and despite their recognized role in oncogenesis, there has been no research on the expression of desaturases in glioblastoma multiforme (GBM). Tumor tissue samples were collected during surgery from 28 patients (16 men and 12 women) diagnosed with GBM. The effect of necrotic conditions and nutritional deficiency (mimicking conditions in the studied tumor zones) was studied in an in vitro culture of human brain (glioblastoma astrocytoma) U-87 MG cells. Analysis of desaturase expression was made by qRT-PCR and the immunohistochemistry method. In the tumor, the expression of stearoyl–coenzyme A desaturase (SCD) and fatty acid desaturases 2 (FADS2) was lower than in the peritumoral area. The expression of other desaturases did not differ in between the distinguished zones. We found no differences in the expression of SCD, fatty acid desaturases 1 (FADS1), or FADS2 between the sexes. Necrotic conditions and nutritional deficiency increased the expression of the studied desaturase in human brain (glioblastoma astrocytoma) U-87 MG cells. The obtained results suggest that (i) biosynthesis of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) in a GBM tumor is less intense than in the peritumoral area; (ii) expressions of SCD, SCD5, FADS1, and FADS2 correlate with each other in the necrotic core, growing tumor area, and peritumoral area; (iii) expressions of desaturases in a GBM tumor do not differ between the sexes; and (iv) nutritional deficiency increases the biosynthesis of MUFA and PUFA in GBM cells.

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“…Actually, tumor metastasis is responsible for .90% of cancer-related mortality. 33,34 In metastasis, tumor cells go through complicated transitions, including separation from the primary tumor mass, migration and invasion through basement membrane, intravasation into blood vessels, extravasation from blood vessels, arrest at distant organs, and ecesis in the target organs. 35,36 The formation of new blood vessels is necessary for proliferation and metastasis of cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer

Song

Xiao

et al. 2017

IJN

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Chemotherapy for aggressive non-small-cell lung cancer (NSCLC) usually results in a poor prognosis due to tumor metastasis, vasculogenic mimicry (VM) channels, limited killing of tumor cells, and severe systemic toxicity. Herein, we developed a kind of multifunctional targeting epirubicin liposomes to enhance antitumor efficacy for NSCLC. In the liposomes, octreotide was modified on liposomal surface for obtaining a receptor-mediated targeting effect, and honokiol was incorporated into the lipid bilayer for inhibiting tumor metastasis and eliminating VM channels. In vitro cellular assays showed that multifunctional targeting epirubicin liposomes not only exhibited the strongest cytotoxic effect on Lewis lung tumor cells but also showed the most efficient inhibition on VM channels. Action mechanism studies showed that multifunctional targeting epirubicin liposomes could downregulate PI3K, MMP-2, MMP-9, VE-Cadherin, and FAK and activate apoptotic enzyme caspase 3. In vivo results exhibited that multifunctional targeting epirubicin liposomes could accumulate selectively in tumor site and display an obvious antitumor efficacy. In addition, no significant toxicity of blood system and major organs was observed at a test dose. Therefore, multifunctional targeting epirubicin liposomes may provide a safe and efficient therapy strategy for NSCLC.

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Reduced Expression of FADS1 Predicts Worse Prognosis in Non-Small-Cell Lung Cancer

Cited by 21 publications

References 29 publications

Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment

Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment

Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme

Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer

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