Reduced forced expiratory volume is associated with increased incidence of atrial fibrillation: the Malmo Preventive Project

Johnson, Linda; Juhlin, Tord; Engström, Gunnar; Nilsson, Peter M.

doi:10.1093/europace/eut255

Cited by 45 publications

(36 citation statements)

References 36 publications

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“…[7,6,24] Reduced lung function has been suggested to be inversely associated with incident atrial fibrillation. [25,18] A higher prevalence of atrial fibrillation in COPD could also be a possible cause of the increased risk of IS in COPD. However, our analysis show that COPD and IS are associated even after adjusting for atrial fibrillation.…”

Section: Discussionmentioning

confidence: 99%

Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease

et al. 2015

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Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease.Söderholm, Martin; Inghammar, Malin; Hedblad, Bo; Egesten, Arne; Engström, Gunnar Link to publication Citation for published version (APA): Söderholm, M., Inghammar, M., Hedblad, B., Egesten, A., & Engström, G. (2016). Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease. European Journal of Epidemiology, 31(2), 159-168. DOI: 10.1007/s10654-015-0113-7 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. ABSTRACT BackgroundIt is uncertain whether the incidence of stroke is increased in patients with chronic obstructive pulmonary disease (COPD), and whether COPD is associated with all subtypes of stroke (i.e. ischemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage). We evaluated the association between COPD and incidence of stroke in a nation-wide cohort study. MethodsAll individuals between 40 and 84 years of age, hospitalised for COPD between 1987and 2003 in Sweden were identified in the Swedish hospital discharge register. For each COPD patient (n=103,419), one reference individual was randomly selected from the general population matched for year of birth, sex and county of residence.After excluding subjects with prior stroke, incidence rates during 10 years follow-up were calculated. Hazard ratios (HR) for stroke comparing COPD patients with reference subjects were estimated using Cox regression adjusting for demographics and comorbidities. ResultsIncidence of all-cause stroke (n events=17,402) was significantly increased in COPD patients compared to reference individuals ConclusionsIncidences of all stroke subtypes are increased in COPD, especially during the first years after COPD diagnosis. The association was independent of several comorbidities, although residual confounding from smoking and hypertension cannot be excluded. A global evaluation of stroke risk factors seems warranted in patients with COPD.

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Section: Discussionmentioning

confidence: 99%

Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease

et al. 2015

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“…Low birth weight is a well‐established risk factor for cardiovascular disease,1 type 2 diabetes mellitus,2 and hypertension,3 as well as several other known atrial fibrillation (AF) risk factors, such as pulmonary function 4, 5. There are 3 previous studies that report on associations between self‐reported birth weight and incident AF, with divergent results.…”

Section: Introductionmentioning

confidence: 99%

Early Life Risk Factors for Incident Atrial Fibrillation in the Helsinki Birth Cohort Study

Johnson

Salonen

Kajantie

et al. 2017

JAHA

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BackgroundEarly life risk factors are associated with cardiometabolic disease, but have not been fully studied in atrial fibrillation (AF). There are discordant results from existing studies of birth weight and AF, and the impact of maternal body size, gestational age, placental size, and birth length is unknown.Methods and ResultsThe Helsinki Birth Cohort Study includes 13 345 people born as singletons in Helsinki in the years 1934–1944. Follow‐up was through national registries, and ended on December 31, 2013, with 907 incident cases. Cox regression analyses stratified on year of birth were constructed for perinatal variables and incident AF, adjusting for offspring sex, gestational age, and socioeconomic status at birth. There was a significant U‐shaped association between birth weight and AF (P for quadratic term=0.01). The lowest risk of AF was found among those with a birth weight of 3.4 kg (3.8 kg for women [85th percentile] and 3.0 kg for men [17th percentile]). High maternal body mass index (≥30 kg/m2) predicted offspring AF; hazard ratio 1.36 (95% CI 1.07–1.74, P=0.01) compared with normal body mass index (<25 kg/m2). Maternal height was associated with early‐onset AF (<65.3 years), hazard ratio 1.47 (95% CI 1.24–1.74, P<0.0001), but not with later onset AF. Results were independent of incident coronary artery disease, hypertension, or diabetes mellitus.ConclusionsHigh maternal body mass index during pregnancy and maternal height are previously undescribed predictors of offspring AF. Efforts to prevent maternal obesity might reduce later AF in offspring. Birth weight has a U‐shaped relation to incident AF independent of other perinatal variables.

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“…With regard to AF, it has been consistently shown that FEV1 and FVC are inversely related with the arrhythmia independently of other factors such as age, gender, smoking, blood pressure, and body mass index [15][16][17]. In this context, it has recently been indicated that impaired pulmonary function, hypercapnia, and high values of pulmonary artery systolic pressure are independent predictors of incident AF [49].…”

Section: Introductionmentioning

confidence: 99%

Electrocardiographic abnormalities and cardiac arrhythmias in chronic obstructive pulmonary disease

Goudis¹,

Konstantinidis

Ntalas

et al. 2015

International Journal of Cardiology

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Reduced forced expiratory volume is associated with increased incidence of atrial fibrillation: the Malmo Preventive Project

Abstract: Impaired lung function is an independent predictor of AF. This may explain some risk of AF that is currently unaccounted for.

Cited by 45 publications

References 36 publications

Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease

Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease

Early Life Risk Factors for Incident Atrial Fibrillation in the Helsinki Birth Cohort Study

Electrocardiographic abnormalities and cardiac arrhythmias in chronic obstructive pulmonary disease

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