Reduced forearm reactive hyperaemia in normoalbuminuric subjects with Type 1 diabetes and retinopathy

Gibney, James; Turner, Ben; Weis, U.; Meeking, Darryl; Cansfield, J.; Watts, Gerald F.; Shaw, Ken; Cummings, Michael H.

doi:10.1111/j.1464-5491.2004.01203.x

Cited by 6 publications

(5 citation statements)

References 36 publications

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“…Gibney et al 6 evaluated the forearm vasodilatory response to reactive hyperaemia (RH) in patients with type 1 diabetes. RH was evaluated using strain-gauge plethysmography, and subjects with retinopathy showed reduced forearm RH responses compared with those with no retinopathy.…”

Section: Discussionmentioning

confidence: 99%

Relationship of systemic endothelial function and peripheral arterial stiffness with diabetic retinopathy

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Relationship of systemic endothelial function and peripheral arterial stiffness with diabetic retinopathy

et al. 2014

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“…Most 5–9 but not all 10–12 studies have found endothelial function to be more markedly impaired in subjects with diabetic microangiopathy. Metabolic alterations of diabetes produce various functional and structural changes at the arteriolar and capillary levels, including the basement membrane, the smooth muscle cells and, in particular, the endothelial cells 2,13 .…”

Section: Discussionmentioning

confidence: 99%

Relationship between diabetic retinopathy and vascular endothelial function in elderly type 2 diabetic Japanese patients without cardiovascular disease

Watanabe

Suzuki

Nakano

et al. 2007

Geriatrics Gerontology Int

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Background: Many recent studies point to the importance, in diabetic patients, of vascular endothelial function as an early marker of not only macrovascular complications but also of microangiopathy. The aim of this study is to investigate the relationship between diabetic retinopathy and endothelial function in elderly diabetic patients by using brachial artery flow-mediated dilation (FMD). Methods:We studied 71 type 2 diabetic patients aged 65 years or older without cardiovascular diseases. The subjects were categorized as three groups: (i) without diabetic retinopathy (n = 49); (ii) with non-proliferative diabetic retinopathy group (n = 15); and (iii) those with preproliferative or proliferative diabetic retinopathy (n = 7). Brachial artery FMD measurement was performed by high-resolution ultrasonography. The Kruskal-Wallis test, the c 2 test and multivariate logistic regression analysis were used to identify associations between both retinopathy and clinical characteristics and FMD.Results: There were no differences in clinical characteristics between the three groups. FMD of the three groups were significantly decreased correlating with the severity of retinopathy (8.03% vs 5.40% vs 2.30%; P = 0.003). Multivariate logistic regression analysis showed that there was a significant correlation between diabetic retinopathy and FMD (odds ratio 0.801; P = 0.009). Conclusion:Our study suggests that FMD has a relation to microangiopathy in elderly diabetic subjects. Prospective studies will be required to determine whether this test has any clinical use for identifying elderly diabetic patients who are likely to develop diabetic retinopathy.

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“…The measurement of this response by strain‐gauge plethysmography is a non‐invasive marker of endothelial‐dependent vasodilatation 27. Post‐hyperaemia forearm blood flow only reflects the vasomotor component of endothelial function, so these findings should not be extrapolated to other endothelial functions 28…”

Section: Discussionmentioning

confidence: 99%

Endothelial dysfunction, measured by reactive hyperaemia using strain‐gauge plethysmography, is an independent predictor of adverse outcome in heart failure

Berrazueta

Guerra‐Ruiz

García‐Unzueta

et al. 2010

European J of Heart Fail

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AimsIn congestive heart failure (CHF), arterial response is regulated by endothelial molecules. The aim of this study was to evaluate whether endothelial dysfunction (ED) was a predictor of outcome in a cohort of patients with heart failure. Methods and resultsEndothelial function was assessed in 242 patients with CHF by forearm reactive hyperaemia measured with intermittent venous occlusion plethysmography using a mercury strain gauge. The main endpoints were: 'total events' (death, heart attack, angina, stroke, NYHA class IV, or hospitalization due to heart failure) analysed using Cox regression for repeated events and 'death'. Patients were followed-up for 5 years. Post-hyperaemia forearm blood flow (PHFABF) was an independent predictor of total events [P ¼ 0.01; hazard ratio [Exp(B)] 0.665, standard error (SE) 0.182]. Risk stratification by basal forearm blood flow (BFABF) showed that patients with basal blood flow above the median (3.03 mL min 21 100 mL 21 ) benefited from an increase in PHFABF, whereas in patients with a BFABF below the median, the increase in PHFABF did not diminish the risk of events. There was no relation between variations in PHFABF and death. ConclusionPost-hyperaemia forearm blood flow, as a measure of ED, is an independent predictor of major events in patients with CHF. A BFABF below the median is more predictive of an increased risk of complications.-Heart failure † Endothelial function † Strain gauge plethysmography † Reactive hyperaemia † Post-hyperaemia forearm blood flow

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Reduced forearm reactive hyperaemia in normoalbuminuric subjects with Type 1 diabetes and retinopathy

Abstract: Retinopathy in subjects with Type 1 diabetes mellitus may reflect a generalized process of endothelial dysfunction, even in the absence of microalbuminuria.

Cited by 6 publications

References 36 publications

Relationship of systemic endothelial function and peripheral arterial stiffness with diabetic retinopathy

Relationship of systemic endothelial function and peripheral arterial stiffness with diabetic retinopathy

Relationship between diabetic retinopathy and vascular endothelial function in elderly type 2 diabetic Japanese patients without cardiovascular disease

Endothelial dysfunction, measured by reactive hyperaemia using strain‐gauge plethysmography, is an independent predictor of adverse outcome in heart failure

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