Reduced functional connectivity in early-stage drug-naive Parkinson's disease: a resting-state fMRI study

Chen, Luo; Song, Wei; Chen, Qin; Zheng, Zhenzhen; Chen, Ke; Cao, Bei; Yang, Jing; Li, Jianpeng; Huang, Xiaoqi; Gong, Qiyong; Shang, Huifang

doi:10.1016/j.neurobiolaging.2013.08.018

Cited by 154 publications

(142 citation statements)

References 68 publications

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“…Cognitive decline associated with PD includes attentional and memory deficits as well as executive and visual dysfunctions (Litvan et al 2012). Previous iFC studies in PD reported abnormal functional interaction in several connectivity networks (Filippi et al 2013;Luo et al 2014;Prodoehl et al 2014). …”

Section: Discussionmentioning

confidence: 99%

The association between alterations of eye movement control and cerebral intrinsic functional connectivity in Parkinson’s disease

Gorges

Müller

Lulé

et al. 2015

Brain Imaging and Behavior

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Patients with Parkinson's disease (PD) present with eye movement disturbances that accompany the cardinal motor symptoms. Previous studies have consistently found evidence that large-scale functional networks are critically involved in eye movement control. We challenged the hypothesis that altered eye movement control in patients with PD is closely related to alterations of whole-brain functional connectivity in association with the neurodegenerative process. Saccadic and pursuit eye movements by video-oculography and 'resting-state' functional MRI (3 Tesla) were recorded from 53 subjects, i.e. 31 patients with PD and 22 matched healthy controls. Video-oculographically, a broad spectrum of eye movement impairments was demonstrated in PD patients vs. controls, including interrupted smooth pursuit, hypometric saccades, and a high distractibility in anti-saccades. Significant correlations between altered oculomotor parameters and functional connectivity measures were observed, i.e. the worse the oculomotor performance was, the more the regional functional connectivity in cortical, limbic, thalamic, cerebellar, and brainstem areas was decreased. Remarkably, decreased connectivity between major nodes of the default mode network was tightly correlated with the prevalence of saccadic intrusions as a measure for distractability. In conclusion, dysfunctional eye movement control in PD seems to be primarily associated with (cortical) executive deficits, rather than being related to the ponto-cerebellar circuits or the oculomotor brainstem nuclei. Worsened eye movement performance together with the potential pathophysiological substrate of decreased intrinsic functional connectivity in predominantly oculomotor-associated cerebral functional networks may constitute a behavioral marker in PD.

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Section: Discussionmentioning

confidence: 99%

The association between alterations of eye movement control and cerebral intrinsic functional connectivity in Parkinson’s disease

Gorges

Müller

Lulé

et al. 2015

Brain Imaging and Behavior

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“…Most of the existing studies on functional alterations in PD use seed-based analysis [8][9][10][11][12][13][14][15][16][17][18]. Our study uses an unbiased, data-driven approach based on ICA that can emphasize broader changes in functional connectivity not restricted to a set of predefined seeds.…”

Section: Discussionmentioning

confidence: 99%

Increased connectivity between sensorimotor and attentional areas in Parkinson’s disease

et al. 2015

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“…The study of functional connectivity (FC) in PD is relatively young (Baudrexel et al, 2011;Göttlich et al, 2013;Hacker et al, 2012;Helmich et al, 2010;Luo et al, 2014;Poston and Eidelberg, 2012;Sharman et al, 2013;Wu et al, 2009Wu et al, , 2011aWu et al, , 2012Yu et al, 2013). An early study evaluating resting-state FC (rsFC) in PD showed that rsFC between the pre-supplementary motor area (pre-SMA) and putamen was decreased, whereas that between the pre-SMA and primary motor cortex (M1) was increased (Wu et al, 2011a).…”

Section: Introductionmentioning

confidence: 99%

Exercise Therapy for Parkinson's Disease: Pedaling Rate Is Related to Changes in Motor Connectivity

et al. 2016

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Forced-rate lower-extremity exercise has recently emerged as a potential safe and low-cost therapy for Parkinson's disease (PD). The efficacy is believed to be dependent on pedaling rate, with rates above the subjects' voluntary exercise rates being most beneficial. In this study, we use functional connectivity magnetic resonance imaging (MRI) to further elucidate the mechanism underlying this effect. Twenty-seven PD patients were randomized to complete 8 weeks of forced-rate exercise (FE) or voluntary-rate exercise (VE). Exercise was delivered using a specialized stationary bicycle, which can augment patients' voluntary exercise rates. The FE group received assistance from the cycle. Imaging was conducted at baseline, end of therapy, and after 4 weeks of follow-up. Functional connectivity (FC) was determined via seed-based correlation analysis, using activationbased seeds in the primary motor cortex (M1). The change in FC after exercise was compared using linear correlation with pedaling rate. Results of the correlation analysis showed a strong positive correlation between pedaling rate and change in FC from the most affected M1 to the ipsilateral thalamus. This effect persisted after 4 weeks of follow-up. These results indicate that a plausible mechanism for the therapeutic efficacy of high-rate exercise in PD is that it improves thalamo-cortical connectivity.

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Reduced functional connectivity in early-stage drug-naive Parkinson's disease: a resting-state fMRI study

Cited by 154 publications

References 68 publications

The association between alterations of eye movement control and cerebral intrinsic functional connectivity in Parkinson’s disease

The association between alterations of eye movement control and cerebral intrinsic functional connectivity in Parkinson’s disease

Increased connectivity between sensorimotor and attentional areas in Parkinson’s disease

Exercise Therapy for Parkinson's Disease: Pedaling Rate Is Related to Changes in Motor Connectivity

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