Reduced Graphene Oxide and Polyaniline Nanofibers Nanocomposite for the Development of an Amperometric Glucose Biosensor

Popov, Anton; Aukštakojytė, Rūta; Gaidukevič, Justina; Lisytė, Viktorija; Kausaitė-Minkstimienė, Asta; Barkauskas, Jurgis; Ramanavičienė, Almira

doi:10.3390/s21030948

Cited by 59 publications

(24 citation statements)

References 54 publications

(60 reference statements)

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“…However, for developing PBGS, the most widely reported strategy is the assembly of ternary and quaternary composites with a plethora of materials, including carbonbased nanomaterials (e.g., graphene [72,73], MWCNT [57,74]), metallic nanoparticles (e.g., Au [57,75], Pt [76,77]), and polymers (e.g., PEO [78], polyacrylic acid [79], and SDS [80]). An example of these strategies was presented by Maity et al, developing a composite of aminated (NH 2 ) MWCNT/PAni/rGO/AuNPs over an SPCE [58].…”

Section: Pani-based Glucose Biosensorsmentioning

confidence: 99%

Progress of Polyaniline Glucose Sensors for Diabetes Mellitus Management Utilizing Enzymatic and Non-Enzymatic Detection

et al. 2022

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Glucose measurement is a fundamental tool in the daily care of Diabetes Mellitus (DM) patients and healthcare professionals. While there is an established market for glucose sensors, the rising number of DM cases has promoted intensive research to provide accurate systems for glucose monitoring. Polyaniline (PAni) is a conductive polymer with a linear conjugated backbone with sequences of single C–C and double C=C bonds. This unique structure produces attractive features for the design of sensing systems such as conductivity, biocompatibility, environmental stability, tunable electrochemical properties, and antibacterial activity. PAni-based glucose sensors (PBGS) were actively developed in past years, using either enzymatic or non-enzymatic principles. In these devices, PAni played roles as a conductive material for electron transfer, biocompatible matrix for enzymatic immobilization, or sensitive layer for detection. In this review, we covered the development of PBGS from 2015 to the present, and it is not even exhaustive; it provides an overview of advances and achievements for enzymatic and non-enzymatic PBGB PBGS for self-monitoring and continuous blood glucose monitoring. Additionally, the limitations of PBGB PBGS to advance into robust and stable technology and the challenges associated with their implementation are presented and discussed.

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Section: Pani-based Glucose Biosensorsmentioning

confidence: 99%

Progress of Polyaniline Glucose Sensors for Diabetes Mellitus Management Utilizing Enzymatic and Non-Enzymatic Detection

et al. 2022

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“…NEGS are comparatively cheaper than EGS. The lack of enzymes confer them better stability and leaves them unaffected by external conditions like pH, temperature, ionic strength ( Wang, 2008 ; Popov et al, 2021 ). Moreover, their ability to give quick results with high sensitivity gives NEGS an upper hand on EGS.…”

Section: Comparison Of Egs With Negsmentioning

confidence: 99%

Recent Advances in Non-Enzymatic Glucose Sensors Based on Metal and Metal Oxide Nanostructures for Diabetes Management- A Review

et al. 2021

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There is an undeniable growing number of diabetes cases worldwide that have received widespread global attention by many pharmaceutical and clinical industries to develop better functioning glucose sensing devices. This has called for an unprecedented demand to develop highly efficient, stable, selective, and sensitive non-enzymatic glucose sensors (NEGS). Interestingly, many novel materials have shown the promising potential of directly detecting glucose in the blood and fluids. This review exclusively encompasses the electrochemical detection of glucose and its mechanism based on various metal-based materials such as cobalt (Co), nickel (Ni), zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), titanium (Ti), iridium (Ir), and rhodium (Rh). Multiple aspects of these metals and their oxides were explored vis-à-vis their performance in glucose detection. The direct glucose oxidation via metallic redox centres is explained by the chemisorption model and the incipient hydrous oxide/adatom mediator (IHOAM) model. The glucose electrooxidation reactions on the electrode surface were elucidated by equations. Furthermore, it was explored that an effective detection of glucose depends on the aspect ratio, surface morphology, active sites, structures, and catalytic activity of nanomaterials, which plays an indispensable role in designing efficient NEGS. The challenges and possible solutions for advancing NEGS have been summarized.

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“…Different methods and conditions are employed for the synthesis of polymers with desired properties. If required, entrapment of some nanomaterials can improve the properties of polymers [2][3][4][5]. All of this leads to a wide range of practical polymer applications.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic Ellipsometry and Quartz Crystal Microbalance with Dissipation for the Assessment of Polymer Layers and for the Application in Biosensing

et al. 2022

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Polymers represent materials that are applied in almost all areas of modern life, therefore, the characterization of polymer layers using different methods is of great importance. In this review, the main attention is dedicated to the non-invasive and label-free optical and acoustic methods, namely spectroscopic ellipsometry (SE) and quartz crystal microbalance with dissipation (QCM-D). The specific advantages of these techniques applied for in situ monitoring of polymer layer formation and characterization, biomolecule immobilization, and registration of specific interactions were summarized and discussed. In addition, the exceptional benefits and future perspectives of combined spectroscopic ellipsometry and QCM-D (SE/QCM-D) in one measurement are overviewed. Recent advances in the discussed area allow us to conclude that especially significant breakthroughs are foreseen in the complementary application of both QCM-D and SE techniques for the investigation of polymer structure and assessment of the interaction between biomolecules such as antigens and antibodies, receptors and ligands, and complementary DNA strands.

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Reduced Graphene Oxide and Polyaniline Nanofibers Nanocomposite for the Development of an Amperometric Glucose Biosensor

Cited by 59 publications

References 54 publications

Progress of Polyaniline Glucose Sensors for Diabetes Mellitus Management Utilizing Enzymatic and Non-Enzymatic Detection

Progress of Polyaniline Glucose Sensors for Diabetes Mellitus Management Utilizing Enzymatic and Non-Enzymatic Detection

Recent Advances in Non-Enzymatic Glucose Sensors Based on Metal and Metal Oxide Nanostructures for Diabetes Management- A Review

Spectroscopic Ellipsometry and Quartz Crystal Microbalance with Dissipation for the Assessment of Polymer Layers and for the Application in Biosensing

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