Reduced hippocampal IL-10 expression, altered monoaminergic activity and anxiety and depressive-like behavior in female mice subjected to chronic social instability stress

Labaka, Ainitze; Gómez-Lázaro, Eneritz; Vegas, Oscar; Pérez-Tejada, Joana; Arregi, Amaia; Garmendia, Larraitz

doi:10.1016/j.bbr.2017.08.002

Cited by 41 publications

(38 citation statements)

References 78 publications

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“…For example, in a study of over 100 adults [64], anxiety and depression were linked to a relatively more pro-inflammatory profile. Also, chronically stressed mice exhibited decreased hippocampal IL-10 expression [65], while pro-inflammatory cytokine responses were unaltered-as also reported in the current study. Current data is the first to our knowledge, to report IL-10 maladaptation already present in adolescents exposed to childhood maltreatment and/or having high anxiety proneness, in the absence of other apparent causative factors or pathology.…”

Section: Discussionsupporting

confidence: 90%

Anxiety: An overlooked confounder in the characterisation of chronic stress-related conditions?

et al. 2020

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Although anxiety disorders are among the most prevalent of psychiatric disorders, childhood trauma-related studies seldom consider anxiety proneness as distinct aetiological contributor. We aimed to distinguish between trauma-and anxiety-associated physiological profiles. South African adolescent volunteers were categorised for trauma exposure (CTQ, mean score 39±11) and anxiety proneness (AP)(CASI, mean score 37±7, STAI-T, mean score 41 ±8). Circulating hormone and leukocyte glucocorticoid receptor levels, as well as leukocyte functional capacity, were assessed. AP was associated with lower DHEAs (P<0.05) and higher leukocyte GR expression (P<0.05). DHEAs was also negatively correlated with anxiety sensitivity (CASI, P<0.05). In conclusion, AP may have more predictive power than trauma in terms of health profile. Increased glucocorticoid sensitivity previously reported after trauma, may be a unique function of anxiety and not trauma exposure per se. DHEAs concentration was identified as potentially useful marker for monitoring progressive changes in HPA-axis sensitivity and correlated with psychological measures of anxiety.

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Section: Discussionsupporting

confidence: 90%

Anxiety: An overlooked confounder in the characterisation of chronic stress-related conditions?

et al. 2020

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“…Models that support the in uence of the HPA axis on depression postulate chronically dysregulated activation of the HPA axis, which is also associated with dysregulation of immune function [8][9][10][11] . Various animal studies have shown the relationship between depression and in ammation [12][13][14][15] . In a human study, Pedraz-Petrozzi recently showed correlations between the severity of depression, assessed with the BDI-FS 16 , and the pro-in ammatory cytokine TNF-α in people with depression.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: The secret behind peripheral inflammation and depression: The hypothalamus

Pedraz-Petrozzi

Blecker

Neumann

et al. 2020

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In recent years there has been increasing evidence of an inflammatory component due to overstimulation of the hypothalamic-pituitary-adrenals (HPA) in depression. The glutamate metabolites (glutamate and glutamine) are important metabolites that are involved in this stimulation. The aim of this study was to determine the concentrations of hypothalamic glutamate metabolites in depression and to investigate their relationship to peripheral inflammation. Participants with diagnosed depression (DE; n = 24) and control subjects without depression (HC; n = 25) were investigated. Hypothalamic glutamate metabolites were recorded using in vivo magnetic resonance spectroscopy. Peripheral cytokines (IL-6, TNF-α, IFN-γ and IL-1β) were assessed using Enzyme-Linked Immunosorbent Assay. For statistical analysis, generalized mixed models were computed using Poisson distributions and a log link function. The results show overall higher hypothalamic glutamate metabolites in DE compared to HC. High TNF-a and IL-1ß concentrations are associated with high hypothalamic glutamate metabolites in DE. These results provide initial evidence that, in depression, increased HPA axis activity is associated with peripheral inflammation favored by hypothalamic glutamate metabolites.

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“…There are animal and human studies, for instance, that showed correlations between systemic in ammation and depression (14)(15)(16)(17)(18)(19)(20)(21)(22). However, studies correlating hypothalamic metabolism with systemic in ammation are needed to con rm this overactivation hypothesis of the HPAA in depression.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Hypothalamic Glutamine-Glutamate Metabolites and Peripheral Pro-Inflammatory Cytokines in Participants with Depression: A Case-Control Study

Blecker

Neumann

et al. 2020

Preprint

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Background: In recent years, there has been increasing evidence of an inflammatory component due to overstimulation of the hypothalamic-pituitary-adrenal axis (HPAA) in depression. The glutamate metabolites (glutamate and glutamine) are important in this stimulation. The aim of this study was to determine the concentrations of hypothalamic glutamate metabolites in depression and to investigate their relationship to peripheral inflammation. Methods: Participants with diagnosed depression (DE; n = 24) and control subjects without depression (HC; n = 25) were investigated. Hypothalamic glutamate metabolites were recorded using in vivo magnetic resonance spectroscopy. Peripheral cytokines (IL-6, TNF-α, IFN-γ and IL-1β) were assessed using Enzyme-Linked Immunosorbent Assay. For statistical analysis, generalized mixed models were computed using Poisson distributions and a log link function. Results: The results show overall higher hypothalamic glutamate metabolites in DE compared to HC. High TNF-α and IL-1β concentrations are associated with high hypothalamic glutamate metabolites in DE. Conclusions: These results provide initial evidence that, in depression, increased HPAA activity is associated with peripheral inflammation favored by hypothalamic glutamate metabolites.

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Reduced hippocampal IL-10 expression, altered monoaminergic activity and anxiety and depressive-like behavior in female mice subjected to chronic social instability stress

Cited by 41 publications

References 78 publications

Anxiety: An overlooked confounder in the characterisation of chronic stress-related conditions?

Anxiety: An overlooked confounder in the characterisation of chronic stress-related conditions?

WITHDRAWN: The secret behind peripheral inflammation and depression: The hypothalamus

WITHDRAWN: Hypothalamic Glutamine-Glutamate Metabolites and Peripheral Pro-Inflammatory Cytokines in Participants with Depression: A Case-Control Study

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