Reduced incidence of postoperative infection after intravenous administration of an immunoglobulin A- and immunoglobulin M-enriched preparation in anergic patients undergoing cardiac surgery

Abstract

A commercially available IgA- and IgM-enriched intravenous immunoglobulin preparation administered immediately after cardiac surgery significantly reduced the incidence of postoperative infections in preoperatively anergic patients.

The Effects of Adjuvant Immunoglobulin M-Enriched Immunoglobulin Therapy on Mortality Rate and Renal Function in Sepsis-Induced Multiple Organ Dysfunction Syndrome: Retrospective Analysis of Intensive Care Unit Patients

“…15 Additionally, the neutralizing effect of IgM is greater than that for other Ig, and IgM administration can significantly reduce the incidence of postoperative infection. 16 Various scoring systems have been developed and used in order to classify the severity of disease in patients entering the ICU. 17 -20 The most successful scoring system for monitoring MODS in the ICU is the Acute Physiology and Chronic Health Evaluation II (APACHE II) system.…”

Immunoglobulin replacement therapy: Is there a role for IgA and IgM?

“…Two cohort studies of patients with common variable immunodeficiency (CVID) showed contrasting results on the association of IgG levels and pretreatment frequency of infections. 2,3 In our unit, a 21-year-old patient receiving IGRT for CVID with bronchiectasis suffered from increased frequency of infective exacerbations. She was placed on multiple trials of different prophylactic antibiotics and her immunoglobulin dose was increased to achieve IgG trough levels above 10 g/L.…”

Food fight! Parenteral nutrition, enteral stimulation and gut-derived mucosal immunity

“…30 SIgA provides the principle antigen-specific immunologic defense against potential pathogens at all mucosal surfaces. [31][32][33] This model provides the classic description of the pathway to mucosal immune response activation but variations on the theme exist. For example, "extra-follicular" pathways appear to exist where lamina propria B cells can be induced by local factors to undergo class switch recombination to IgA+.…”

“…Several human studies showed that lowered mucosal IgA levels were associated with reduced resistance to infection, specifically pneumonia. 32,109 Neonatal studies convincingly demonstrate that populating the GI tract with immunoglobulin-producing cells and intraepithelial GALT cells depend upon some enteral nutrient stimulation. [110][111][112] The degree to which the reciprocal of this process exists in adult humans poses a practical question that remains inadequately investigated but a potentially fruitful area for research.…”