Reduced myoelectric activity in the sphincter of Oddi in a new model of chronic cholangitis in rabbits: an <i>in vivo</i> and <i>in vitro</i> study

Yk, Liu; Zh, LI; Liu, N-Z; He, Qing; H, Lin; Wang, Xiujun; Xw, Li; Jh, Dong

doi:10.1111/j.1365-2982.2010.01500.x

Cited by 6 publications

(2 citation statements)

References 37 publications

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“…Studies have shown that the reactivity to agonists CCK-8 of rabbits with chronic cholecystitis significantly decreased, and myoelectric activity of SO and its response to agonists CCK-8 and KCI are decreased in rabbits with chronic cholangitis both in vivo and in-vitro 9 . Both clinical and experimental types of research have confirmed that acupuncture at GB34, LR14, and auricular concha has a good curative effect on corresponding biliary diseases 10 – 13 .…”

Section: Discussionmentioning

confidence: 99%

Bi-directional regulation of acupuncture on extrahepatic biliary system: An approach in guinea pigs

Zhao

Luo

et al. 2017

Sci Rep

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Clinically, acupuncture affects the motility of the extrahepatic biliary tract, but the underlining mechanisms are still unknown. We applied manual acupuncture (MA) and electrical acupuncture (EA) separately at acupoints Tianshu (ST25), Qimen (LR14), Yanglingquan (GB34), and Yidan (CO11) in forty guinea pigs (4 groups) with or without atropinization under anesthesia while Sphincter of Oddi (SO) myoelectric activities and gallbladder pressure were monitored. In both MA and EA groups, stimulation at ST25 or LR14 significantly increased the frequency and amplitude of SO myoelectrical activities and simultaneously decreased the gallbladder pressure as compared to the pre-MA and pre-EA (P < 0.05). On the contrary, stimulation at GB34 or CO11 significantly decreased SO myoelectricity and increased the gallbladder pressure (P < 0.05). Pretreatment with atropine could abolish the effect of stimulation at acupoints ST25, GB34 and LR14 (P > 0.05), although significant myoelectricity increases were still inducible with MA or EA stimulation at CO11 (P < 0.05). In summary, acupuncture has bi-directional effects to gallbladder pressure and SO function, which probably due to autonomic reflex and somatovisceral interactions.

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Section: Discussionmentioning

confidence: 99%

Bi-directional regulation of acupuncture on extrahepatic biliary system: An approach in guinea pigs

Zhao

Luo

et al. 2017

Sci Rep

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“…In the guinea pig lithogenic model, EMG was used to detect the myoelectric difference in the Oddi sphincter at different stages under a high cholesterol diet, indicating that Oddi sphincter dysfunction caused by a high cholesterol diet may be one of the pathogenic mechanisms of cholesterol gallstones[ 86 ]. Liu et al [ 87 ] also found Oddi sphincter dysfunction in rabbits with chronic cholangitis and proved that the intracellular calcium mobilization pathway was involved in the relaxation of the sphincter under pathological conditions.…”

Section: Electrophysiological Research On the Gallbladder And Biliary...mentioning

confidence: 99%

Clinical application and research progress of extracellular slow wave recording in the gastrointestinal tract

Ding¹,

Guo²,

Cui³

et al. 2022

WJGS

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The physiological function of the gastrointestinal (GI) tract is based on the slow wave generated and transmitted by the interstitial cells of Cajal. Extracellular myoelectric recording techniques are often used to record the characteristics and propagation of slow wave and analyze the models of slow wave transmission under physiological and pathological conditions to further explore the mechanism of GI dysfunction. This article reviews the application and research progress of electromyography, bioelectromagnetic technology, and high-resolution mapping in animal and clinical experiments, summarizes the clinical application of GI electrical stimulation therapy, and reviews the electrophysiological research in the biliary system.

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A Novel Rabbit Model for Benign Biliary Stricture Formation and the Effects of Medication Infusions on Stricture Formation

Yang

Wang

et al. 2018

Dig Dis Sci

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Reduced myoelectric activity in the sphincter of Oddi in a new model of chronic cholangitis in rabbits: an in vivo and in vitro study

Abstract: Myoelectric activity of SO and its response to agonists are decreased in rabbits with chronic cholangitis both in vivo and in vitro.

Cited by 6 publications

References 37 publications

Bi-directional regulation of acupuncture on extrahepatic biliary system: An approach in guinea pigs

Bi-directional regulation of acupuncture on extrahepatic biliary system: An approach in guinea pigs

Clinical application and research progress of extracellular slow wave recording in the gastrointestinal tract

A Novel Rabbit Model for Benign Biliary Stricture Formation and the Effects of Medication Infusions on Stricture Formation

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