Reduced novelty-P3 associated with increased behavioral distractibility in schizophrenia

Mismatch Negativity reduction in the left cortical regions in first-episode psychosis and in individuals at ultra high-risk for psychosis

“…In the case of the P3a, this asymmetry effect seems to continue along the illness progression (Cortiñas et al, 2008). Moreover, in the case of P3b, its amplitude reduction has been associated to corresponding asymmetric neuroanatomical abnormalities in schizophrenia (Ford, 1999;Ribolsi et al, 2009).…”

Increased Distractibility in Schizotypy: Independent of Individual Differences in Working Memory Capacity?

“…The novelty P3 is associated with the orienting response and its behavioural consequence of directing attention toward the task-irrelevant stimuli thereby resulting in impairment to ongoing task performance. The interpretation offered by Cortinas et al (2008) is that the schizophrenic patients applied fewer attentional resources to the ongoing task and therefore the allocation of albeit reduced attentional resources to the deviant stimuli drastically affected behavioural performance. The foregoing suggests, therefore, that engagement in the task in addition to potential differences in auditory processing, might modulate the increased susceptibility to deviance distraction within high schizotypes.…”

“…One must also be cautious, however, about interpreting a diminished event-related brain potential as an index of reduced behavioural attentional capture because a behavioural-electrophysiological dissociation is sometimes reported. For example, Cortinas et al (2008) showed that schizophrenic patients compared to controls showed an increased behavioural distraction, but a reduced novelty P3, to a deviant complex novel tone among to-be-ignored repetitive standard tones when engaged in a visually-based categorisation task. The novelty P3 is associated with the orienting response and its behavioural consequence of directing attention toward the task-irrelevant stimuli thereby resulting in impairment to ongoing task performance.…”

Clozapine and glycinamide prevent MK-801-induced deficits in the novel object recognition (NOR) test in the domestic rabbit (Oryctolagus cuniculus)

“…We argue that this mechanism may be distinct from the case of the rodent NOR test, where slowly decaying (up to 24 h) episodic-like memory appears to operate [14] (but for alternative interpretations, see [69]). A model that potentially involves alterations in primary sensory processing could be useful for modeling deficits in "bottom-up" processes that have been described in schizophrenics, including deficits in habituation and automatic responses to novelty [10,27,43,45,65]. Some of these sensory processing deficits have been strongly associated with negative symptom scores [10,13,27,68].…”