Reduced numbers of plasmacytoid dendritic cells in aged blood donors

Pérez-Cabezas, Begoña; Naranjo-Gómez, Mar; Fernández, Marco A.; Grífols, Juan R.; Pujol-Borrell, Ricardo; Borràs, Francesc E.

doi:10.1016/j.exger.2007.05.010

Cited by 72 publications

(56 citation statements)

References 18 publications

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“…A reduction in IFN-α production by pDCs has been observed in mice (StoutDelgado et al, 2008) and in geriatric individuals when compared to young controls, which could not be explained by changes in apoptosis (Canaday et al, 2010;Sridharan et al, 2011). These findings indicate that reduced responses of the immune system in the elderly to influenza and other viruses may be due to the age-associated decreases in pDCs (Jing et al, 2009;Pérez-Cabezas et al, 2007;Shodell and Siegal, 2002). Impaired IFN-I and -III production by pDCs may be linked to an alteration in IRF-7 phosphorylation, which is impaired in DCs of aged subjects but increased in young subjects (Sridharan et al, 2011).…”

Section: Cytokine Expression By Dcs During Ageingmentioning

confidence: 90%

“…Significant decreases in plasmacytoid DCS (pDCs) and CD11c + CD8 + DCs along with a significant increase in CD11c + CD8 -myeloid DCs (mDCs) are observed in aged mice (Wong et al, 2010). Similarly, significant decreases in pDCs were observed in elderly human subjects (Canaday et al, 2010;Jing et al, 2009;Pérez-Cabezas et al, 2007;Shodell and Siegal, 2002) although the oldest sub-group of subjects tested were 50-65 years of age, which is considered middle-aged by others (Mysliwska, 1999;Shodell and Siegal, 2002). Significantly lower numbers of mDCs and pDCs have been observed in the frail elderly when compared to both healthy young and healthy elderly subjects (Jing et al, 2009).…”

Section: Numbers Of DC Subsets With Agementioning

confidence: 99%

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Nutrition, diet and immunosenescence

Maijó

Clements

Ivory

et al. 2014

Mechanisms of Ageing and Development

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Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly. We would like to thank the reviewers for their careful review of our manuscript, which has been revised accordingly. Below, we have provided a point-by-point reply to the issues raised: AbstractAgeing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly.

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Section: Cytokine Expression By Dcs During Ageingmentioning

confidence: 90%

Section: Numbers Of DC Subsets With Agementioning

confidence: 99%

Nutrition, diet and immunosenescence

Maijó

Clements

Ivory

et al. 2014

Mechanisms of Ageing and Development

View full text Add to dashboard Cite

show abstract

“…A phenomenon has been reported in children during the first decade of life that their pDCs numbers decline rapidly whereas the numbers of mDCs remain relatively stable (20,21). There are at least three studies demonstrated an age-related decline of pDC (22)(23)(24) but two other studies showed no changes (19,25). Conflicting findings have also been reported with regard to the age-related changes in mDCs.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques

et al. 2009

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“…Absolute numbers of circulating myeloid DCs is affected by declining health status (Perez-Cabezas et al, 2007;Panda et al, 2010;Shodell & Siegal, 2002;Jing et al, 2009). The use of Ficoll-enriched cells versus whole blood, differences in sample sizes, age groups, health status, genetic factors and subset definitions may contribute to the inconsistent findings with age in these studies.…”

Section: Dendritic Cellsmentioning

confidence: 99%