Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children

Brito, Stéphane A. De; Viding, Essi; Sebastian, Cherian; Kelly, Philip A.; Mechelli, Andrea; Maris, Helen; McCrory, Eamon

doi:10.1111/j.1469-7610.2012.02597.x

Cited by 176 publications

(141 citation statements)

References 52 publications

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“…CTQ scores were specifically associated with anterior cingulate gyrus, precuneus, and parahippocampal gyrus cortical thinning. These studies parallel morphometric work BioMed Research International 3 that has noted grey matter density and volumetric reductions in medial/prefrontal regions and cingulate in adults and children with a history of maltreatment/trauma (e.g., physical neglect) [21][22][23][24][25][26]. These structures have been implicated in emotion regulation and memory processing and tend to exhibit morphometric and functional changes in MDD.…”

Section: Introductionsupporting

confidence: 49%

“…Exploratory rmANOVAs (HAMD 17 scores and age as covariates; hemisphere as with-and groups as between-subject factors; significance was set at < .01) yielded a trend for an onset group × childhood trauma group interaction for superior temporal cortex thickness (F[1,25] = 5.98, = .022), with pairwise comparisons indicating a trend for a difference in cortical thickness between the pediatric ( = 8; 2.59 ± .14) and adult ( = 8; 2.77 ± .14) MDD onset groups with childhood abuse ( = .02). For frontal pole thickness, an onset group × childhood trauma group × hemisphere interaction trend existed (F [1,25] …”

Section: Two Group Analyses (Mdd Groups: Childhood Abuse Group and Nomentioning

confidence: 99%

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Relationship between the COMT-Val158Met and BDNF-Val66Met Polymorphisms, Childhood Trauma and Psychotic Experiences in an Adolescent General Population Sample

Prock¹

2015

Holistic Perspectives on Trauma

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Background. Major depressive disorder (MDD) neural underpinnings may differ based on onset age and childhood trauma. We assessed cortical thickness in patients who differed in age of MDD onset and examined trauma history influence. Methods. Adults with MDD ( = 36) and controls (HC; = 18) underwent magnetic resonance imaging. Twenty patients had MDD onset <24 years of age (pediatric onset) and 16 had onset >25 years of age (adult onset). The MDD group was also subdivided into those with ( = 12) and without ( = 19) physical and/or sexual abuse as assessed by the Childhood Trauma Questionnaire (CTQ). Cortical thickness was analyzed with FreeSurfer software. Results. Thicker frontal pole and a tendency for thinner transverse temporal cortices existed in MDD. The former was driven by the pediatric onset group and abuse history (independently), particularly in the right frontal pole. Inverse correlations existed between CTQ scores and frontal pole cortex thickness. A similar inverse relation existed with left inferior and right superior parietal cortex thickness. The superior temporal cortex tended to be thinner in pediatric versus adult onset groups with childhood abuse. Conclusions. This preliminary work suggests neural differences between pediatric and adult MDD onset. Trauma history also contributes to cytoarchitectural modulation. Thickened frontal pole cortices as a compensatory mechanism in MDD warrant evaluation.

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Section: Introductionsupporting

confidence: 49%

Section: Two Group Analyses (Mdd Groups: Childhood Abuse Group and Nomentioning

confidence: 99%

Relationship between the COMT-Val158Met and BDNF-Val66Met Polymorphisms, Childhood Trauma and Psychotic Experiences in an Adolescent General Population Sample

Prock¹

2015

Holistic Perspectives on Trauma

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“…17 In addition, a study of 18 maltreated children, compared with 20 nonmaltreated children, showed reduced grey matter in the medial OFC and the left middle temporal gyrus in those with maltreatment. 18 Thus, these results suggested the OFC and ACC should be included in addition to the hippocampus and DMPFC as regions of interest for the present study.…”

Section: Introductionmentioning

confidence: 99%

Effect of childhood maltreatment on brain structure in adult patients with major depressive disorder and healthy participants

Chaney

Carballedo

Amico

et al. 2014

J Psychiatry Neurosci

124

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“…Radiographic hippocampal changes in abused children are less pronounced than those seen in adults reporting to have experienced abuse as children, but there is evidence of reduced cortical thickness of the ventral anterior cingulate, superior frontal gyrus, and the OFC, as well as of the left middle temporal area and lingual gyrus [52]. Studies support the theory that different brain regions show unique sensitive periods to the effects of stress.…”

Section: Childhood Maltreatmentmentioning

confidence: 95%

Childhood Maltreatment in the Migraine Patient

Tietjen

Buse

Collins

2016

Curr Treat Options Neurol

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Maltreatment during childhood increases vulnerability to a host of health disorders, including migraine. Putative mechanisms linking maltreatment and migraine include stress-induced dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, as well as disruption of other stress-mediating homeostatic systems, including those involving endocannabinoids, monoamine neurotransmitters, oxytocin, and inflammation. Prolonged elevation of glucocorticoids alters the neural architecture of the limbic system, resulting in the structural as well as functional changes described in both maltreatment and in migraine. Although treatment trials for migraine have not stratified participants by abuse history, strategies, such as cognitive behavioral therapy, which alter stress responsivity, may be particularly effective in this subgroup. Some therapies involving the endocannabinoid, serotonergic, oxytonergic, and inflammatory systems are under investigation for migraine. Anti-epileptic drugs such as valproate and topiramate, which are FDA approved for migraine treatment, are also known to interfere with epigenetic changes induced by stress. Discerning the role for this mechanism in treatment of maltreated migraineurs may introduce another therapeutic avenue.

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Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children

Cited by 176 publications

References 52 publications

Relationship between the COMT-Val158Met and BDNF-Val66Met Polymorphisms, Childhood Trauma and Psychotic Experiences in an Adolescent General Population Sample

Relationship between the COMT-Val158Met and BDNF-Val66Met Polymorphisms, Childhood Trauma and Psychotic Experiences in an Adolescent General Population Sample

Effect of childhood maltreatment on brain structure in adult patients with major depressive disorder and healthy participants

Childhood Maltreatment in the Migraine Patient

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