Reduced PTEN Protein Expression and Its Prognostic Implications in Canine and Feline Mammary Tumors

Ressel, Lorenzo; Millanta, Francesca; Caleri, E; Innocenti, Vm; Poli, Alessandro

doi:10.1354/vp.08-vp-0273-p-fl

Cited by 42 publications

(33 citation statements)

References 41 publications

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“…The results of the study about PTEN protein expression in this study were similar to those previously reported in human (Li et al, 1997;Bose et al, 2002) and veterinary (Kanae et al, 2006;Qiu et al, 2008;Ressel et al, 2009) literature. PTEN protein expression was positively correlated with clinico-pathological parameters commonly associated with a favorable prognosis, such as a complex histotype, the absence of lymphatics invasion and a longer overall survival, as previously reported for canine mammary tumours (Ressel et al, 2009).…”

Section: Discussionsupporting

confidence: 91%

“…PTEN protein expression was positively correlated with clinico-pathological parameters commonly associated with a favorable prognosis, such as a complex histotype, the absence of lymphatics invasion and a longer overall survival, as previously reported for canine mammary tumours (Ressel et al, 2009). Regarding E-cadherin expression, in our study an altered expression was observed in malignant tumours when compared with benign ones, and in simple carcinomas when compared with complex type.…”

Section: Discussionsupporting

confidence: 88%

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Co-localization of PTEN and E-cadherin in canine mammary hyperplasias and benign and malignant mammary tumors

Asproni

Ressel

Millanta

et al. 2015

Research in Veterinary Science

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Fifty-four canine mammary lesions (15 hyperplasias, 7 adenomas and 32 carcinomas) were submitted to immunohistochemical analysis for the evaluation of PTEN and E-cadherin co-expression. Subjects bearing mammary carcinomas were also submitted to a 2-year follow-up study to compare immunohistochemical results with overall survival. All the hyperplastic samples stained positive for both markers, 100% of adenomas were positive for PTEN and 86% for E-cadherin, and 69% and 34% of carcinomas were positive for PTEN and E-cadherin, respectively. Statistical analysis showed a positive correlation between these two proteins both considering all (p b 0.01) or malignant tumors (p < 0.05). The female dogs bearing tumors positively-stained for both markers had a longer overall survival (p < 0.05) and absence of lymphatics invasion (p < 0.05). Simultaneous double immunofluorescence confirmed the co-localization of the two proteins in neoplastic cells. Results reported in this study confirm the tumor suppressor effect of these two molecules.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Co-localization of PTEN and E-cadherin in canine mammary hyperplasias and benign and malignant mammary tumors

Asproni

Ressel

Millanta

et al. 2015

Research in Veterinary Science

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“…in dogs with osteosarcoma (37), melanoma (31), hemangiosarcoma (14) and mammary gland tumors (30,52,53). The loss of PTEN protein expression can be a useful marker in identifying mammary gland carcinoma in dogs (54).…”

mentioning

confidence: 99%

Hamartoma: a rare developmental disorder

Bartyzel¹,

Max²,

Gruszczyńska³

et al. 2017

Medycyna Weterynaryjna

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SummaryHamartoma is a developmental disorder of various body parts and organs. It is characterized by a nonneoplastic growth of tissue with an uneven distribution and proportion of individual cells. Lesions progress for several years, but usually do not give clinical symptoms, and do not undergo malignant transformation. They occur alone or coexist with other defects, sometimes forming a characteristic clinical picture of a syndrome of congenital defects. Mutations in genes, such as PTEN, GLI3, SDH B/D, PIK3CA and ACT1, cause a dysfunction of the tumor suppressor gene and result in an increased neoplastic transformation. Hamartoma is a lesion between developmental disorders and benign tumors, which occurs frequently in humans, but is very rare in domestic animals. In a histopathological examination, however, it is diagnosed relatively often. In the veterinary literature, both hamartoma and choristoma are attributed mostly to errors in embryogenesis and are not considered as preneoplastic lesions.

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“…4,34 The Elston and Ellis (EE) histologic grading system (also known as the Nottingham Grading System) has been widely adopted by veterinary investigators for the grading of feline mammary carcinoma. 2,4,19,28,[32][33][34]40 This system represents the ''gold standard'' in assessment of invasive human breast cancer, whereby distinct histopathologic features (ie, percentage tubule formation, nuclear pleomorphism, and mitotic count) are scored and added together to produce a grade, which then correlates with degree of malignancy and prognosis. 8,30,31 Use of this grading system by veterinary pathologists is based primarily on evidence suggesting that feline mammary carcinoma represents a suitable model for human * Indicates equal contribution 1 breast cancer, particularly the more aggressive estrogennegative carcinomas.…”

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confidence: 99%

Prognostic Value of Histologic Grading for Feline Mammary Carcinoma

et al. 2014

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Feline mammary carcinoma is highly malignant and generally associated with a poor prognosis, although studies suggest the range of survival times in affected cats is broad. Histologic grading of these tumors is achieved using the Elston and Ellis system, originally developed for human breast cancer. In cats, however, classification using this method has variable prognostic value. Therefore, objectives of this study were (1) to evaluate the Elston and Ellis grading system for feline mammary carcinoma in a predominantly spayed population and (2) to determine whether modification of this system or development of a novel system improved the prognostic value of histologic grading. Survey data and histologic features for 108 carcinomas from 97 cats were analyzed with respect to overall survival. Elston and Ellis grading failed to correlate significantly with overall survival. Using multivariable analysis, lymphovascular invasion, nuclear form, and mitotic count each demonstrated independent prognostic significance (P ¼ .008, <.001, and .004, respectively). Modifications of the Elston and Ellis system and a novel grading system were proposed based on these results; all showed significant correlation with overall survival (P < .001). Median survival times were 27, 29, or 31 months for grade I; 14, 12, or 14 months for grade II; and 13, 5, or 8 months for grade III carcinomas using the mitotic-modified Elston and Ellis, the revised Elston and Ellis, or the novel grading system, respectively. Based on this retrospective study, adoption of the species-specific systems as proposed here may improve the prognostic value of histologic grading for feline mammary carcinoma.

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Reduced PTEN Protein Expression and Its Prognostic Implications in Canine and Feline Mammary Tumors

Cited by 42 publications

References 41 publications

Co-localization of PTEN and E-cadherin in canine mammary hyperplasias and benign and malignant mammary tumors

Co-localization of PTEN and E-cadherin in canine mammary hyperplasias and benign and malignant mammary tumors

Hamartoma: a rare developmental disorder

Prognostic Value of Histologic Grading for Feline Mammary Carcinoma

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