Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression

Abstract

Background: Anxious depression (AD), which is generally recognized as a common clinical subtype of major depressive disorder (MDD), holds distinctive features compared with unanxious depression (UAD). However, the neural mechanism of AD still remains unrevealed. To give insight to it, we compared resting-state functional magnetic resonance amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) between AD and UAD patients. Method: The data were collected from 60 AD patients, 38 UAD patients, and 60 matched healthy controls. The ALFF and seed-based FC were examined. Pearson correlations were computed between ALFF/FC and clinical measures. Results: In Comparison with the UAD group, the ALFF value of the right orbital part of middle frontal gyrus (RO-MFG) decreased in AD group. Specifically, the ALFF values of the RO-MFG were negatively correlated with retardation factor scores in AD group (r =-0.376, p = 0.003). Conclusions: AD patients exhibited disturbed intrinsic brain function compared with UAD patients. The decreased activity of the RO-MFG is indicative of the alterations involved in the neural basis of AD.

Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy

“…41,42 A previous resting-state functional MRI study found decreased activity of the right ORBmid in patients with anxious depression, speculating this region to be responsible for mood regulation and suicidal tendency. 40 In our study, the NBS analyses identified a subnetwork with decreased structural connections in the TAO cohort. All connections in the subnetwork involved the right ORBmid, highlighting the core role of this node in the disrupted structural network.…”

“…The ORBmid lies in the orbitofrontal cortex (OFC), which is functioned in mood regulation and management of interpersonal relationships and social behaviour. 39,40 Decreased activity in the OFC has been observed in various anxiety-related disorders. 41,42 A previous resting-state functional MRI study found decreased activity of the right ORBmid in patients with anxious depression, speculating this region to be responsible for mood regulation and suicidal tendency.…”

Regional Homogeneity in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study

“…Some studies suggest that the signal changes of OMFG are related to the changes in neurological function of patients with anxiety and depression. Previous studies have found that patients with severe anxiety and depression had significantly lower amplitude of low-frequency fluctuation values in the brain regions, means that the brain regions activity obviously changed ( Zhao et al, 2019 ). In our study, the MCI patients ReHo values for the OMFG were significantly higher compared to HCs: thus, we hypothesize that it is possible to identify patients with complications of anxiety and depression by monitoring the changes in signal values in this brain region.…”

Altered Intrinsic Regional Spontaneous Brain Activity in Patients With Severe Obesity and Meibomian Gland Dysfunction: A Resting-State Functional Magnetic Resonance Imaging Study

“…As is known, chronic attention deficit is a feature of many neurological diseases. fMRI has shown that the MFG is active in attention tasks and event analysis, indicating its importance in sustained attention ( Zhao et al, 2020 ). In addition, interference from the right MFG can promote network associations with other areas to elevate persistent attentiveness.…”