Reduced Serum Levels of Triglyceride, Very Low Density Lipoprotein Cholesterol and Apolipoprotein B in Parkinson’s Disease Patients

Wei, Qiang; Tian, Yanghua; Xu, Fang; Chen, Xianwen; Wang, Kai

doi:10.1371/journal.pone.0075743

Cited by 42 publications

(31 citation statements)

References 30 publications

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“…Apo A1 is the main apolipoprotein of HDL‐C, and Apo B is the main structural protein of LDL‐C and very low‐density lipoprotein cholesterol. The serum levels of TC, TG, and LDL‐C in PD patients are lower than those of healthy people, so changes in blood lipid levels may be related to PD …”

Section: Introductionmentioning

confidence: 99%

“…The serum levels of TC, TG, and LDL-C in PD patients are lower than those of healthy people, so changes in blood lipid levels may be related to PD. [4][5][6][7] As a heterogeneous amino acid cysteine, homocysteine (Hcy) is an important intermediate in the metabolic pathway of sulfur-containing amino acids that primarily participates in energy metabolism and methylation. Hyperhomocysteinaemia occurs when the plasma Hcy level exceeds 15 μmol/L.…”

Section: Introductionmentioning

confidence: 99%

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Correlations between blood lipid, serum cystatin C, and homocysteine levels in patients with Parkinson's disease

Zhu

et al. 2019

Psychogeriatrics

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Aim The aim was too study the correlations between blood lipid, serum cystatin C (Cys C) and homocysteine (Hcy) levels in patients with Parkinson's disease (PD). Methods A total of 322 PD patients and 214 healthy subjects were selected as case and control groups, respectively. The risk factors were explored by logistic regression analysis. The case group was subtyped according to main motor symptoms and age of onset. The correlations of significantly different indices with age, duration of disease, and equivalent dose of levodopa were studied by Spearman's correlation analysis. Receiver operating characteristic curves were plotted to analyze diagnostic values. Results Compared to the control group, the PD group had lower serum total cholesterol, triglyceride, and apolipoprotein B (Apo B) levels and higher high‐density lipoprotein cholesterol (HDL‐C), Hcy, and Cys C levels (P < 0.05). Decreased Apo B level and increased HDL‐C and Hcy levels were independent risk factors (P < 0.05). The Cys C level of early‐onset patients was lower than of late‐onset patients (P < 0.05). Hcy (r = 0.198, P < 0.05) and Cys C (r = 0.281, P < 0.05) levels were positively correlated with age. Triglyceride level was negatively correlated with age (r = −0.202, P < 0.05) and disease duration (r = −0.198, P < 0.05). Unified Parkinson's Disease Rating Scale III score was positively correlated with disease duration (r = 0.435, P < 0.05) and equivalent dose of levodopa (r = 0.423, P < 0.05). The areas under the curve for Apo B, HDL‐C, and Hcy levels were 0.341, 0.588, and 0.643, respectively (P < 0.05). The combination of Apo B, HDL‐C, and Hcy levels showed high diagnostic value, with a sensitivity of 76.4% and specificity of 69.5%. Conclusions Low serum levels of total cholesterol, triglyceride, and Apo B, and high levels of HDL‐C, Hcy, and Cys C may be correlated with PD onset and progression. Decreased Apo B level and elevated HDL‐C and Hcy levels are independent risk factors. Early‐onset and late‐onset PD may have different progression mechanisms.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlations between blood lipid, serum cystatin C, and homocysteine levels in patients with Parkinson's disease

Zhu

et al. 2019

Psychogeriatrics

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“…Lipids and lipid metabolism have been linked to many disorders, both somatic [9][10][11][12][13][14] and neuropsychiatric [15][16][17][18][19][20][21]. McEwen and Stellar [22] proposed that exposure to frequent and chronic environmental stressors may produce insufficient or overreacting responses, resulting in cumulative damage that physiologic systems have endured in the process of adapting to stressors, increasing the risk of disease.…”

Section: Introductionmentioning

confidence: 99%

Application of fatty acid and lipid measurements in neuropsychiatry

Grela

Rachel

Cole

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:The importance of lipids in the understanding of disease states is constantly increasing. Whilst the link between metabolic disorders and lipids seems to be clear, interpreting lipid regulation in the context of neuropsychiatric disorders is a new approach. Mental disorders account for almost 15% of the total global disease burden with Alzheimer's disease, depression or schizophrenia being amongst the most widespread mental disorders in the general population. For this reason rapid and early diagnosis is crucial and finding the right biomarkers is of great importance. Lipids appear to be essential in learning the aetiopathology of neuropsychiatric diseases as well as in biomarker research as they are most abundantly present in the brain. This study discusses recent findings in neuropsychiatry in the context of lipid analysis.

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“…However, there is evidence that PD patients have a lower cardiometabolic risk compared to the general population. PD patients have lower TC, TG, and LDL-C levels [3,27,28], which suggests that decreased lipid levels correlate with a lower risk of CHD. However, the associations between TC/HDL-C and TG/HDL-C ratios with CHD risk in PD patients have not been well researched.…”

Section: Introductionmentioning

confidence: 99%

Decreased Serum Lipid Levels and Ratios Correlate with Low Prevalence of Coronary Heart Disease in Patients with Parkinson's Disease

Bao¹,

Hu²,

Chen³

et al. 2018

Clin. Lab.

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Background: Patients with Parkinson's disease (PD) are at a lower risk of suffering cardiovascular events, but the underlying factors for this decreased risk remain unclear. Serum triglycerides (TG) and total cholesterol (TC), and their expression relative to high-density lipoprotein cholesterol (TG/HDL-C and TC/HDL-C), are independent predictors of cardiovascular events. This study aimed to determine if PD patients have decreased lipid levels and lipid ratios, which may underlie the decreased risk of coronary heart disease (CHD). Methods: This retrospective study included 92 PD patients (PD group), 450 control subjects with no CHD (OD group), and 450 CHD patients (CHD group). We analyzed serum lipid levels and lipid ratios in each group. Results: There were significant differences in TC (F = 10.459, p < 0.0001), TG (F = 46.856, p < 0.0001), low density lipoprotein cholesterol (LDL-C) (F = 6.910, p = 0.001), high density lipoprotein cholesterol HDL-C (F = 30.694, p < 0.0001), TC/HDL-C (F = 32.675, p < 0.0001), and TG/HDL-C (F = 45.554, p < 0.0001) between all three groups; TC/LDL-C (F = 2.518, p = 0.081) was not significantly different between groups. Compared to the CHD group, PD patients had lower TC (p < 0.0001), TG (p < 0.0001), LDL-C (p = 0.001), TG/HDL-C (p < 0.0001), and TC/HDL-C (p < 0.0001); TC/LDL-C (p = 0.563) and HDL-C (p = 0.196) were not significantly different. TC and LDL-C levels were positively correlated within individual groups (all p < 0.0001). In addition, TG and HDL-C were negatively correlated in the OD and CHD groups (p < 0.0001); no significant negative association was observed in the PD group (p = 0.077). TG/HDL and LDL-C levels were inversely correlated in the CHD group (p < 0.0001) and weakly positively correlated in the PD (p = 0.159) and OD (p = 0.199) groups. Conclusions: TC/HDL and TG/HDL ratios were significantly lower in PD patients compared to CHD patients, suggesting there is a strong correlation between lipid ratios and incidence of CHD in PD patients.

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Reduced Serum Levels of Triglyceride, Very Low Density Lipoprotein Cholesterol and Apolipoprotein B in Parkinson’s Disease Patients

Cited by 42 publications

References 30 publications

Correlations between blood lipid, serum cystatin C, and homocysteine levels in patients with Parkinson's disease

Correlations between blood lipid, serum cystatin C, and homocysteine levels in patients with Parkinson's disease

Application of fatty acid and lipid measurements in neuropsychiatry

Decreased Serum Lipid Levels and Ratios Correlate with Low Prevalence of Coronary Heart Disease in Patients with Parkinson's Disease

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