Reduced Systemic Levels of IL‐10 Are Associated with the Severity of Obstructive Sleep Apnea and Insulin Resistance in Morbidly Obese Humans

Abstract

Obstructive sleep apnea (OSA) has been related to elevation of inflammatory cytokines and development of insulin resistance in morbidly obese (MO) subjects. However, it is still unclear whether the systemic concentration of anti-inflammatory mediators is also affected in MO subjects directly related to the severity of OSA and level of insulin resistance. Normal weight and MO subjects were subjected to overnight polysomnography in order to establish the severity of OSA, according to the apnea-hypopnea index (AHI). Blood samples were obtained for estimation of total cholesterol and triglycerides, insulin, glucose, insulin resistance, tumor necrosis factor alpha (TNF-α), interleukin 12 (IL12), and interleukin 10 (IL-10). Serum levels of IL-10 were significantly lower in MO subjects with OSA than in MO and control individuals without OSA. Besides being inversely associated with serum TNF-α and IL-12, decreased IL-10 levels were significantly related to increased AHI, hyperinsulinemia, and insulin resistance. Serum IL-10 is significantly reduced in morbidly obese subjects with severe OSA while also showing a clear relationship with a state of hyperinsulinemia and insulin resistance probably regardless of obesity in the present sample. It may be of potential clinical interest to identify the stimulatory mechanisms of IL-10 in obese individuals with OSA.

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“…Serum levels of this cytokine appeared to be inversely associated with insulin resistance and TNF‐α serum levels in normal and morbidly obese subjects (43). Peripheral overexpression of IL‐10 was seen to improve glucose tolerance and to reduce Tnf‐ a expression in WAT of ob/ob mice (44).…”

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“…En este sentido, se ha descrito que el incremento del AU intracelular favorece la infiltración de macrófagos en el tejido adiposo, lo cual lleva a un incremento subsecuente en las concentraciones extracelulares de TNF-α. Este fenómeno se ha observado en los adipocitos [33][34][35][36][37][38][39][40] ,…”

Could omega-3 fatty acids a therapeutic treatment of the immune-metabolic consequence of intermittent hypoxia in obstructive sleep apnea?

“…Leon-Cabrera and colleagues found decrease in IL-10 levels were significantly related to increased Apnea-Hypopnea Index (AHI), hyperinsulinemia, and insulin resistance than morbid and control individuals without OSA. (Leon-Cabrera et al, 2015). Pro-inflammatory cytokines have a role in the development of insulin resistance and cardiovascular disease (Qian et al, 2012).…”