Reduced transfer of visuomotor adaptation is associated with aberrant sense of agency in schizophrenia

Bansal, Sonia; Murthy, Karthik G; Fitzgerald, Justin; Schwartz, Barbara L.; Joiner, Wilsaan M.

doi:10.1016/j.neuroscience.2019.06.012

Cited by 8 publications

(7 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both the primary motor cortex and visual cortex are part of the visuomotor network [57]. Reduced visuomotor adaptation has also been reported in schizophrenia and in individuals with ADHD [58,59].…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota from persons with attention-deficit/hyperactivity disorder affects the brain in mice

Tengeler¹,

Dam

Wiesmann³

et al. 2020

Microbiome

105

View full text Add to dashboard Cite

Background: The impact of the gut microbiota on host physiology and behavior has been relatively well established. Whether changes in microbial composition affect brain structure and function is largely elusive, however. This is important as altered brain structure and function have been implicated in various neurodevelopmental disorders, like attention-deficit/hyperactivity disorder (ADHD). We hypothesized that gut microbiota of persons with and without ADHD, when transplanted into mice, would differentially modify brain function and/or structure. We investigated this by colonizing young, male, germ-free C57BL/6JOlaHsd mice with microbiota from individuals with and without ADHD. We generated and analyzed microbiome data, assessed brain structure and function by magnetic resonance imaging (MRI), and studied mouse behavior in a behavioral test battery.Results: Principal coordinate analysis showed a clear separation of fecal microbiota of mice colonized with ADHD and control microbiota. With diffusion tensor imaging, we observed a decreased structural integrity of both white and gray matter regions (i.e., internal capsule, hippocampus) in mice that were colonized with ADHD microbiota. We also found significant correlations between white matter integrity and the differentially expressed microbiota. Mice colonized with ADHD microbiota additionally showed decreased resting-state functional MRI-based connectivity between right motor and right visual cortices. These regions, as well as the hippocampus and internal capsule, have previously been reported to be altered in several neurodevelopmental disorders. Furthermore, we also show that mice colonized with ADHD microbiota were more anxious in the open-field test. Conclusions: Taken together, we demonstrate that altered microbial composition could be a driver of altered brain structure and function and concomitant changes in the animals' behavior. These findings may help to understand the mechanisms through which the gut microbiota contributes to the pathobiology of neurodevelopmental disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Gut microbiota from persons with attention-deficit/hyperactivity disorder affects the brain in mice

Tengeler¹,

Dam

Wiesmann³

et al. 2020

Microbiome

105

View full text Add to dashboard Cite

show abstract

“…This finding agrees with previous reports of both behavioral (Moore et al, 2011) and neural (Williams, et al, 2013;Giersch, et al, 2016) evidence aberrant habituation in schizophrenic patients. Previous studies have also found that deficiency of motor adaptation correlates with positive clinical symptoms in schizophrenia (Linney et al, 1998;Van Dael et al, 2006;Garety et al, 2011;Bansal et al, 2019). These effects are probably related to an impaired implicit learning of new rules or contexts (Frith et al, 2000;Blakemore et al, 2002;Ford & Mathalon, 2005;Hauser et al, 2011;Martinelli et al, 2017) and may be exacerbated in situations of diminished environmental control, ambiguity, and unpredicted events (Moore et al, 2011;Gallagher & Trigg, 2016, Di Plinio et al, 2019a, 2019b.…”

Section: The Strength Of This Interaction Between Trial Type and Contmentioning

confidence: 95%

“…Thus, it is reasonable to expect that critical insights into the constitution of the sense of agency can be achieved by investigating the prospective and retrospective sense of agency as interacting components within a context that is continuously updated through implicit sensorimotor learning. (Frith et al, 2000;Blakemore et al, 2002;Ford & Mathalon, 2005;, Martinelli et al, 2017Bansal et al, 2019), we investigated how psychosis-relevant personality traits interact with the embodiment of a dynamic sense of agency. Considering previous literature on the association between uncertainty (or ambiguity) and psychosis (Linney et al, 1998;Van Dael et al, 2006;Garety et al, 2011), we hypothesized that there could be an interaction between the prospective and retrospective components which may create ambiguous situations of "conflict" between the expected and actual action outcomes and that this interaction may be relevant for psychosis-relevant traits.…”

Section: Introductionmentioning

confidence: 99%

The evolving sense of agency: Context recency and quality modulate the interaction between prospective and retrospective processes

Plinio¹,

Arnò²,

Perrucci³

et al. 2020

Preprint

View full text Add to dashboard Cite

Humans acquire a sense of agency through their interactions with the world and their sensory consequences. Previous studies have highlighted stable agency-related phenomena like intentional binding, which depend on both prospective, context-dependent and retrospective, outcome-dependent processes. In the current study, we investigated the interaction between prospective and retrospective processes underlying the adaptation of an ongoing sense of agency. The results showed that prospective intentional binding developed during a temporal window of up to 20 prior events were independent of the nature of the ongoing event. By contrast, the characteristics of the ongoing event retrospectively influenced prospective intentional binding developed during a temporal window narrower than 6 prior events. These findings characterize the interaction between prospective and retrospective mechanisms as a fundamental process to continuously update the sense of agency through sensorimotor learning. High psychosis-like experience traits weakened this interaction, suggesting that reduced adaption to the context contribute to altered self-experience.

show abstract

“…The study of sensorimotor adaptation in schizophrenia is clinically interesting because these deficits have been linked to a reduced “sense of agency,” that is, the ability to distinguish between self-caused sensations and those due to external sources. This form of failure in self- or error monitoring could in part explain some psychotic symptoms such as paranoid hallucinations [15], incoherent language, and formal thought disorders in schizophrenia [16].…”

Section: Introductionmentioning

confidence: 99%

“…Knoblich et al [16] found impairments in the detection of a perturbation, but not in the ability to automatically compensate for it in a gain task. Rowland et al [34] and Bansal et al [15] demonstrated intact adaptation in reaching tasks and mirror drawing has been found to be impaired, dependent of the type of antipsychotic drug used for treatment [35]. In other words, sensorimotor adaptation in schizophrenia needs further exploration.…”

Section: Introductionmentioning

confidence: 99%

Impaired Sensorimotor Adaption in Schizophrenia in Comparison to Age-Matched and Elderly Controls

et al. 2021

View full text Add to dashboard Cite

Background: The “cognitive dysmetria hypothesis” of schizophrenia proposes a disrupted communication between the cerebellum and cerebral cortex, resulting in sensorimotor and cognitive symptoms. Sensorimotor adaptation relies strongly on the function of the cerebellum. Objectives: This study investigated whether sensorimotor adaptation is reduced in schizophrenia compared with age-matched and elderly healthy controls. Methods: Twenty-nine stably treated patients with schizophrenia, 30 age-matched, and 30 elderly controls were tested in three motor adaptation tasks in which visual movement feedback was unexpectedly altered. In the “rotation adaptation task” the perturbation consisted of a rotation (30° clockwise), in the “gain adaptation task” the extent of the movement feedback was reduced (by a factor of 0.7) and in the “vertical reversal task,” up- and downward pen movements were reversed by 180°. Results: Patients with schizophrenia adapted to the perturbations, but their movement times and errors were substantially larger than controls. Unexpectedly, the magnitude of adaptation was significantly smaller in schizophrenia than elderly participants. The impairment already occurred during the first adaptation trials, pointing to a decline in explicit strategy use. Additionally, post-adaptation aftereffects provided strong evidence for impaired implicit adaptation learning. Both negative and positive schizophrenia symptom severities were correlated with indices of the amount of adaptation and its aftereffects. Conclusions: Both explicit and implicit components of sensorimotor adaptation learning were reduced in patients with schizophrenia, adding to the evidence for a role of the cerebellum in the pathophysiology of schizophrenia. Elderly individuals outperformed schizophrenia patients in the adaptation learning tasks.

show abstract

Reduced transfer of visuomotor adaptation is associated with aberrant sense of agency in schizophrenia

Cited by 8 publications

References 91 publications

Gut microbiota from persons with attention-deficit/hyperactivity disorder affects the brain in mice

Gut microbiota from persons with attention-deficit/hyperactivity disorder affects the brain in mice

The evolving sense of agency: Context recency and quality modulate the interaction between prospective and retrospective processes

Impaired Sensorimotor Adaption in Schizophrenia in Comparison to Age-Matched and Elderly Controls

Contact Info

Product

Resources

About