Reduced urinary excretion of homocysteine could be the reason of elevated plasma homocysteine in patients with psychiatric illnesses

İpçioğlu, Osman Metin; Özcan, Ömer; Gültepe, Mustafa; Ateş, Alpay; Başoğlu, Cengiz; Çakır, Erdinç

doi:10.1016/j.clinbiochem.2008.04.010

Cited by 12 publications

(12 citation statements)

References 42 publications

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“…At a high concentration, homocysteine is considered to be a neurotoxic substance, causing activation of N ‐methyl d ‐aspartate receptors and leading to excitotoxicity. By impairing neural plasticity and promoting neuronal degeneration, homocysteine could contribute to the pathogenesis of neurodegenerative and psychiatric disorders 11 . Additionally, homocysteine is a methyl donor to S‐adenosylmethionine when activated, suggesting that aberrant DNA methylation due to hyperhomocysteinemia may be involved in the pathogenesis of bipolar disorder as well as in schizophrenia 12 …”

Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinemia in Tunisian bipolar I patients

Ezzaher

Mouhamed

Mechri

et al. 2011

Psychiatry Clin Neurosci

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Aims:The aim of the present study was to investigate hyperhomocysteinemia in Tunisian bipolar I patients according to 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism. Methods:The subjects consisted of 92 patients with bipolar I disorder diagnosed according to DSM-IV, and 170 controls. Plasma total homocysteine, folate and vitamin B12 were measured. MTHFR C677T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism.Results: Compared with controls, patients had a significantly higher homocysteine level (16.4 Ϯ 9.8 vs 9.6 Ϯ 4.5 mmol/L; P < 0.001) and a significantly lower folate level (3.2 Ϯ 0.9 vs 6.5 Ϯ 3.2 mg/L; P < 0.001). C677T MTHFR polymorphism genotype frequencies were in Hardy-Weinberg equilibrium. After adjustment for MTHFR C677T genotypes, hypofolatemia, hypovitamin B12 and for potential confounding factors, the odds ratio (OR) of hyperhomocysteinemia associated with bipolar disorder remained significant (OR, 5.53; 95% confidence interval: 1.92-15.86; P = 0.001). In patients, there was no significant change in hyperhomocysteinemia, hypofolatemia and hypovitamin B12 with regard to the clinical and therapeutic characteristics, whereas the highest prevalence of hyperhomocysteinemia was found in depressive patients and when illness duration was >12 years. Hypofolatemia was seen in all patients on lithium and in the majority of patients on carbamazepine, and the highest prevalence of hypovitamin B12 was noted in patients taking carbamazepine. Conclusion:Hyperhomocysteinemia was more frequent in bipolar I patients independent of C677T polymorphism. Patients had reduced levels of folate, which modulates homocysteine metabolism. Indeed, this finding indicates that folate supplementation may be appropriate for bipolar patients with hyperhomocysteinemia.

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Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinemia in Tunisian bipolar I patients

Ezzaher

Mouhamed

Mechri

et al. 2011

Psychiatry Clin Neurosci

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“…The nervous system is particularly sensitive to extracellular homocysteine. Indeed, homocysteine has neurotoxic and vasculotoxic effects (26)(27)(28), and is also a risk factor for atherosclerosis, atherothrombosis, and endothelial dysfunction (29,30). In fact, homocysteine can be transformed into cystathionine via cystathionine-β-synthase activity; as a result of this cystathionine-β-synthase action, the antioxidant glutathione can compensate for potential oxidative damage from excess homocysteine (31).…”

Section: Relationship Between One-carbon Metabolism and Neurological mentioning

confidence: 99%

Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry

Coşar¹,

İpçioğlu²,

Özcan³

et al. 2014

Turk J Med Sci

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This work aims to study recent climatic oscillations and their influence on sedimentation in the Ria de Vigo, a coastal embayment in Galicia, NW Spain. It is based on the study of clay mineral assemblages, in conjunction with other proxies (granulometric, geochemical, geochronological and microfaunal), in the core KSGX 24. A Benthic Foraminifera High Productivity (BFHP) proxy was used to determine changes in the flux of organic matter (OM) at the bottom of the study area. Total organic carbon (TOC) content is not a suitable proxy to estimate changes in the past supply of OM due to diagenetic processes. The sedimentation was finest in 3 sections: ~ 230-214 cm, ~ 185-73 cm and ~ 20-0 cm. These muddy sections are characterised, in general, by higher proportions of detrital minerals, concentrations of several chemical elements related to lithogenic sources and BFHP values. In addition, these sections are impoverished in carbonates, Ca, Sr and La when compared with the layers with the highest sand content. The clay mineral assemblage of the studied site, characterised by the dominance of illite, intermediate concentrations of kaolinite and minor amounts of smectite and chlorite, reveals the prevalence of a typical temperate humid climate in the last 3 ka BP, the estimated age for the core base. However, the quantities of illite and chlorite increase in the muddy layers. The characteristics of these muddy layers were interpreted as representing relatively cold climatic oscillations associated with the strengthening of northerly winds and the prevalence of an upwelling regime corresponding to well-known periods, such as the first cold period of the Upper Holocene (~ 2.9 ka cal BP), the Dark Ages (between ~ 2.2 -1.2 ka cal BP) and the Little Ice Age (~ 0.6 ka cal BP).

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“…Hyperhomocysteinemia can be caused by either increased homocysteine production or decreased renal clearance 26. In our study, the elevated plasma tHcy levels could be the result of vitamin B 12 and folate deficiency as well as the decreased renal clearance in the chromate exposed workers.…”

Section: Discussionmentioning

confidence: 55%

“…Vitamin B 12 and folate deficiency may cause elevated blood homocysteine level 24 25. Thus, plasma tHcy has been recommended as a biochemical marker of vitamin B 12 or folate deficiency 26. Previous research showed that the kidney may play an important role in vitamin B 12 , folate and homocysteine metabolism 8–11.…”

Section: Discussionmentioning

confidence: 99%

Vitamin B₁₂and folate deficiency and elevated plasma total homocysteine in workers with chronic exposure to chromate

et al. 2011

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Reduced urinary excretion of homocysteine could be the reason of elevated plasma homocysteine in patients with psychiatric illnesses

Cited by 12 publications

References 42 publications

Hyperhomocysteinemia in Tunisian bipolar I patients

Hyperhomocysteinemia in Tunisian bipolar I patients

Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry

Vitamin B₁₂and folate deficiency and elevated plasma total homocysteine in workers with chronic exposure to chromate

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Reduced urinary excretion of homocysteine could be the reason of elevated plasma homocysteine in patients with psychiatric illnesses

Cited by 12 publications

References 42 publications

Hyperhomocysteinemia in Tunisian bipolar I patients

Hyperhomocysteinemia in Tunisian bipolar I patients

Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry

Vitamin B12and folate deficiency and elevated plasma total homocysteine in workers with chronic exposure to chromate

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Vitamin B₁₂and folate deficiency and elevated plasma total homocysteine in workers with chronic exposure to chromate