Reducing delay in the diagnosis of pregnancy‐associated breast cancer: How imaging can help us

Taylor, Donna; Lazberger, Joanne; Ives, Angela; Wylie, Elizabeth; Saunders, Christobel

doi:10.1111/j.1754-9485.2010.02227.x

Cited by 58 publications

(52 citation statements)

References 24 publications

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“…The other diagnostic delays were due to the patients attributing the disease symptoms to pregnancy (3/8) and lactation (2/8) or the patients not seeking medical care on time (2/8). Our results differ somewhat from those of Taylor et al [7] who reviewed the diagnostic work-up of 22 women with PABC as a part of large population-based national gestational BC study. They identified 5 (22.7%) patients with a diagnostic delay of 4-12 weeks and 4 (18.2%) patients with a diagnostic delay of more than 6 months.…”

Section: Discussioncontrasting

confidence: 56%

“…Pregnancy and lactation has significant physiological impacts on breast tissue due to remarkable changes in the hormonal milieu that cause increased breast firmness and nodularity [7,11]. These physiological changes render clinical examination difficult and, as a consequence, reported delays in diagnosis are common and could range up to 10 months [7,8,10,12,13]. According to a comprehensive review by Woo et al [10], the median diagnostic delay in more recent studies was reported as 1 or 2 months, while older studies described much longer periods of delay.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that women with PABC are diagnosed with more advanced-stage disease and larger tumors when compared to non-PABCs [5,6]. Although this advanced presentation was generally thought to be the result of late diagnosis of patients, in whom the signs and the symptoms of the breast mass is partly obscured by the physiological changes of pregnancy and lactation, there have been very few studies that specifically investigated the possible causes of diagnostic delay in women with PABC [7]. Therefore, our aim in this study was to evaluate the clinicopathological characteristics of patients with PABC with a special focus on diagnostic delays and the identifiable causes of diagnostic delays.…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy-Associated Breast Cancer: Clinicopathological Characteristics of 20 Cases with a Focus on Identifiable Causes of Diagnostic Delay

et al. 2014

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Background: The primary objective of this study was to evaluate the clinicopathological characteristics of patients with pregnancy-associated breast cancer (PABC), with a special focus on diagnostic delays and the identifiable causes of diagnostic delays. Patients and methods: Clinicopathological data of patients treated for PABC between 2003 and 2012 at Hacettepe University Hospital was retrospectively reviewed. Results: 20 patients with PABC were included. The pathological examination revealed predominance of invasive ductal carcinoma (80%), grade III tumors (65%) and advanced-stage (III-IV) disease (75%). In 8 patients (40%), there was a diagnostic delay between occurrence of the presenting symptoms and the initiation of breast mass workup. For these 8 patients, the main identifiable causes of diagnostic delay were the attribution of disease-related symptoms to pregnancy or lactation in 5 (63%) and negligence of symptoms in 2 (25%). Conclusions: PABC mostly presents with advanced-stage disease, and there can be a substantial diagnostic delay before these patients receive treatment. Preconceptional, gestational and postpartum examination of women of reproductive age should include a thorough breast examination and should provide adequate information regarding the physiological changes in breast tissue and the possible pathological symptoms.

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pregnancy-Associated Breast Cancer: Clinicopathological Characteristics of 20 Cases with a Focus on Identifiable Causes of Diagnostic Delay

et al. 2014

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“…According to literature; the Breast Imaging Reporting and Data System (BI-RADS); galactocele accounts for estimated 5% of breast complaints [5]. Accordingly, [12] Delay in galactocelic diagnosis can be relayed to hypertrophy of breast tissue during breast-feeding (lactation) and pregnancy (gravidae) which can spike symptoms [13]. Breast x-ray (mammography) in lactating women often shows dense breast tissue, hence the emphasis on ultrasound as a preferred imaging choice which carries no risk of fetal radiation [14].…”

Section: Discussionmentioning

confidence: 99%

Superficial Galactocelic Progression, Size-Variation and Assessment in a Patient

Afodun¹,

Quadri²,

Masud³

et al. 2017

ABCR

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Breast cysts (galactocele) form in the mammary gland from ductal obstruction. Multiple pathologic entities may produce complex cystic breast lesions. Ultrasound is presently the first primary modality in breast evaluation after physical palpitation. We report a progressive case of multiple cysts in a 32-year-old woman, ranging from 28 mm to 20 mm. Though in-situ milk (sono-penic) appears sterile, the superficial presentation (externally) is that of a firm mass. Due to the known hazards of radioactive mammography, this case report proves the usefulness of sonar to image, map, measure, identify and diagnose breast pathology. In women with dense-heavy breast, ultrasound examination will play an important role in screening palpable and non-palpable masses.

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“…With the regard to the latter, further challenges arise in the normal breast during lactation. Namely, tCho is generally detected during that time, but breast cancer can occur during lactation and when it does, it is usually detected late [38]. Overall, it is seen that many different cut-points have been used for tCho in attempts to distinguish cancerous breast lesions from benign breast tissue.…”

Section: In Vivo Mrs For Detecting Breast Cancer: Reliance Upon Totalmentioning

confidence: 99%

Visualizing hidden components of envelopes non-parametrically in magnetic resonance spectroscopy: Phosphocholine, a breast cancer biomarker

Belkić

2017

J Math Chem

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A key advantage of rational polynomials as a quotient of two polynomials is their automatically built-in polar representation. Rational polynomials are thus the most suitable for describing functions with peaks, such as those in magnetic resonance spectra (MRS). The Padé approximant is the most important of these rational polynomials because of its uniqueness for the power series expansion of the given function. Non-parametric analysis through the fast Padé transform (FPT) is a convenient initial step for processing MRS time signals, since it can be carried out once the expansion coefficients of the polynomials are generated from the time signal, without polynomial rooting. We applied the FPT to synthesized MRS time signals similar to those encoded in vitro from breast cancer. Padé-based non-parametric envelopes generated with and without spectra partitioning are studied. Comparisons of these total shape spectra with the related Padé component spectra were made. Phosphocholine (PC) and phosphoethanolamine (PE), separated by a mere 0.001 parts per million of chemical shift, were resolved in the non-parametric partitioned envelopes. However, in the non-parametric FPT without partitioning, a single composite smooth Lorentzian peak (PC + PE) was generated in envelopes, with no indication whatsoever that two resonances were present. Subsequent parametric analysis (quantification) by the FPT confirmed that PC completely underlies the much more abundant PE. This problem, chosen to illustrate the usefulness in the non-parametric partitioned envelopes, has clinical implications. Namely, PC is a cancer biomarker which thus far was not identified with in vivo MRS using envelopes from the conventional Fourier-based (single-polynomial) processing.

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Reducing delay in the diagnosis of pregnancy‐associated breast cancer: How imaging can help us

Cited by 58 publications

References 24 publications

Pregnancy-Associated Breast Cancer: Clinicopathological Characteristics of 20 Cases with a Focus on Identifiable Causes of Diagnostic Delay

Pregnancy-Associated Breast Cancer: Clinicopathological Characteristics of 20 Cases with a Focus on Identifiable Causes of Diagnostic Delay

Superficial Galactocelic Progression, Size-Variation and Assessment in a Patient

Visualizing hidden components of envelopes non-parametrically in magnetic resonance spectroscopy: Phosphocholine, a breast cancer biomarker

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