Cryptocurrencies have transgressed ever-changing economic trends in the global economy, owing to their conveyance, security, trust, and the ability to make transactions without the aid of formal institutions and governing bodies. However, the adoption of cryptocurrency remains low among stakeholders, including e-retailers. Thus, the current work explores the intentions of e-retailers in the Asia and Pacific region to adopt cryptocurrencies. This study considers the TAM-based SOR, with a combination of non-cognitive attributes (compatibility and convenience) proposed as stimuli for e-retailers to adopt the examined cryptocurrencies. The findings indicate that the proposed non-cognitive attributes are critical in determining e-retailers’ technostress (emotional state). Moreover, it was found that technostress among e-retailers profoundly impacts their intentions to adopt cryptocurrency in business settings. Meanwhile, regulatory support communication can be used to help regulatory bodies and governing institutions control the future economy worldwide. The proposed study offers significant theoretical and practical contributions through its investigation of e-retailers’ intentions to adopt cryptocurrency for the first time in the particular context of technostress and regulatory support.