Reducing Ischemia-Reperfusion Injury in Rat Island Groin Flaps Using Dexamethasone

Dolan, Robert W.; Kerr, Donald; Schneiderman, Todd E.; Arena, Sebastian

doi:10.1097/00000637-199509000-00011

Cited by 23 publications

(16 citation statements)

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“…To control postoperative pain, buprenorphine (0.05 mg/kg) was given every 2 hours. The proportion of flap survival was determined using a method described by our group previously 5 . Flaps were evaluated daily for up to 7 days.…”

Section: Methodsmentioning

confidence: 99%

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Systemic neutrophil intrinsic 5‐lipoxygenase activity and CD 18 receptor expression linked to reperfusion injury

et al. 1998

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Section: Methodsmentioning

confidence: 99%

“…Prior studies have shown that anti‐inflammatories including phospholipase A 2 (PLA 2 ) and 5‐lipoxygenase (5‐LO) inhibitors reduce i/r injury 5,6 . In vitro studies correlate reduced receptor expression with 5‐LO inhibition implicating the 5‐LO metabolic pathway in receptor up‐regulation 7 .…”

Section: Introductionmentioning

confidence: 99%

Systemic neutrophil intrinsic 5‐lipoxygenase activity and CD 18 receptor expression linked to reperfusion injury

et al. 1998

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“…One leading mechanism of this toxicity is believed to involve reactive oxygen radical species (ROS) generation and neutrophil accumulation. Based on this relationship, treatment of the flaps with either exogenous superoxide dismutase (SOD) [3], catalase [4], allopurinol [5] vitamin C [6], dexamethasone [7], heparin [8], or deferoxamine [9] significantly increase survival.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of melatonin on random pattern skin flap necrosis in pinealectomized rat

Gürlek¹,

Aydoğan²,

Parlakpınar³

et al. 2003

Journal of Pineal Research

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: Random pattern skin flaps are still widely used in plastic surgery. However, necrosis in the distal portion resulting from ischemia is a serious problem, increasing the cost of treatment and hospitalization. Free oxygen radicals and increased neutrophil accumulation play an important role in tissue injury and may lead to partial or complete flap necrosis. To enhance skin flap viability, a variety of pharmacological agents have been intensively investigated. The aim of this study is to test the effects of melatonin, the chief secretory product of the pineal gland and a highly effective antioxidant, on random pattern skin flap survival in rats. Herein, to investigate the physiological and pharmacological role of melatonin on dorsal skin flap survival. Pharmacological (0.4, 4 and 40 mg/kg) levels of melatonin were given intraperitoneally (i.p.). For this, pinealectomized (Px) and sham operated (non‐Px) rats were used. The effects of melatonin on levels of malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH) and the activities of glutathione peroxidase (GSH‐Px) and superoxide dismutase (SOD) were measured in the skin flap. The ratio of skin flap necrosis was compared among the experimental groups by using planimetry. MDA and NO levels were found to be higher in Px than non‐Px rats; while GSH levels and GSH‐Px, and SOD activities were reduced. Melatonin administration to Px rats reduced MDA and NO levels and increased GSH, GSH‐Px, SOD levels. Melatonin also reduced the ratio of flap necrosis determined by using planimetry and supported through the photography. In conclusion, these results show that both physiological and pharmacological concentrations of melatonin improve skin flap viability.

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“…Intravascular fluid extravasates into the perivascular space with enough pressure eventually to compress the vessels 22‐24 . Damaged endothelial cells release cytokines, initiating neutrophil infiltration and an acute inflammatory response 25‐27 . Activated neutrophils release free radicals (HOCl, RNHCl), arachidonic acid metabolites, and other active substances, cascading further inflammation 28 .…”

Section: Integrated Theory Of No‐reflowmentioning

confidence: 99%

“…Activated neutrophils release free radicals (HOCl, RNHCl), arachidonic acid metabolites, and other active substances, cascading further inflammation 28 . These activated neutrophils obstruct capillary lumena, contributing to flow cessation 15,26,27,29,30 …”

Section: Integrated Theory Of No‐reflowmentioning

confidence: 99%

An Integrated Theory of the No‐Reflow Phenomenon and the Beneficial Effect of Vascular Washout on No‐Reflow

1999

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Reducing Ischemia-Reperfusion Injury in Rat Island Groin Flaps Using Dexamethasone

Cited by 23 publications

References 0 publications

Systemic neutrophil intrinsic 5‐lipoxygenase activity and CD 18 receptor expression linked to reperfusion injury

Systemic neutrophil intrinsic 5‐lipoxygenase activity and CD 18 receptor expression linked to reperfusion injury

Protective effect of melatonin on random pattern skin flap necrosis in pinealectomized rat

An Integrated Theory of the No‐Reflow Phenomenon and the Beneficial Effect of Vascular Washout on No‐Reflow

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