Reducing radiation dermatitis during ongoing radiation therapy: an innovative film-forming wound dressing

Quilis, Amparo Compañ; Martín, J.A. Carneros; Rodríguez, Concepción; Sánchez, Pablo; Ribes, Juan Luis

doi:10.1007/s13566-018-0356-5

Cited by 8 publications

(13 citation statements)

References 10 publications

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“…In all cases described above the studied wound dressing served as a self-leveling and film-forming dressing preventing trans-epidermal water loss and enabled a moist wound healing environment that is known to promote faster reepithelialisation and reduce the skin's acute inflammatory response [6].…”

Section: Discussionmentioning

confidence: 99%

“…A critical consideration needs to be pointed out from this case series: it is noteworthy how the wound dressing was used with similarly excellent efficacy and safety results across several types of cancer localizations. The flexible nature of the gel allows a perfect adaptation to all those body surfaces in which common physical sheeting are unsuccessful or impossible to use, such as those with high mobility (joints), high friction (axilla), wetsk in (mucosa), and higher hygienic necessities (perineum) [6].…”

Section: Discussionmentioning

confidence: 99%

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The Use of an Innovative Film-Forming Wound Dressing in the Treatment of Radiation Dermatitis during Concomitant Chemotherapy

Villandiego¹,

Aramberri²

2018

JCT

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There is currently no consensus regarding the management of acute cutaneous reactions emerging from a concurrent treatment of radio-and chemotherapy, the goal of this case study series is to provide scientific evidence based on clinical practice regarding the efficacy of a film-forming wound dressing for patients receiving combined cancer therapy, in particular examples where the reactions are expected to be intense. In all the described cases, management of acute skin reactions allowed the cancer therapy to be finalized, instead of being interrupted due to an increase in the severity of the reactions. It has been shown in the current literature that the lack of compliance with treatment plans correlates with poorer clinical outcome. Evidence from the cases presented suggest that the studied dressing is safe and efficacious in the treatment and the prevention of acute cutaneous reactions arising from combined cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Use of an Innovative Film-Forming Wound Dressing in the Treatment of Radiation Dermatitis during Concomitant Chemotherapy

Villandiego¹,

Aramberri²

2018

JCT

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“…The other study proved StrataXRT's noninferiority to Mepitel film in ARD prevention [41]. The only trial studying the therapeutic use of StrataXRT for ARD was a prospective study by Quilis et al, which showed a significant improvement in RISRAS score for patients receiving StrataXRT dressings at the onset of dermatitis signs [42].…”

Section: Gel Dressingsmentioning

confidence: 99%

Modern Dressings in Prevention and Therapy of Acute and Chronic Radiation Dermatitis—A Literature Review

2022

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Radiotherapy is an integral part of modern oncology, applied to more than half of all patients diagnosed with cancer. It can be used alone or in combination with surgery or chemotherapy. However, despite the high precision of radiation delivery, irradiation may affect surrounding healthy tissues leading to the development of toxicity. The most common and clinically significant toxicity of radiotherapy is acute and chronic radiation dermatitis, which could result in desquamation, wounds, nonhealing ulcers, and radionecrosis. Moreover, preoperative radiotherapy impairs wound healing after surgery and may lead to severe wound complications. In this review, we comprehensively discuss available types of dressings used in the management of acute and chronic radiation dermatitis and address their efficacy. The most effective ways of preventing acute radiation dermatitis are film dressings, whereas foam dressings were found effective in its treatment. Data regarding dressings in chronic radiation dermatitis are scarce. This manuscript also contains authors’ consensus.

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“…The product is reported to have no bolus effect [20,21], have water-proof properties [21], and be conducive for areas with facial hair [21]. A noncontrolled, pretest-posttest study (n = 44) has demonstrated the acceptability and efficacy of StrataXRT Ò [22]. However, to our knowledge, there is not yet any randomised controlled trials evaluating the effects of silicone-based film-forming gel products for preventing and managing RD in patients receiving radical radiation treatment.…”

mentioning

confidence: 99%

A single-blind, randomised controlled trial of StrataXRT® – A silicone-based film-forming gel dressing for prophylaxis and management of radiation dermatitis in patients with head and neck cancer

Chan

Blades

Jones

et al. 2019

Radiotherapy and Oncology

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Aim: Investigate the effects of StrataXRT Ò versus 10% Glycerine (Sorbolene cream) for preventing and managing radiation dermatitis in patients with head and neck cancer receiving radical radiotherapy (!50 Gy) with or without chemotherapy or biotherapy. Methods: A single-blind, randomised controlled, superiority trial was conducted. Patients either received StrataXRT Ò or Sorbolene (usual care). Skin toxicity, pain, itching and skin-related quality of life scores were collected from baseline, and up to four weeks post-treatment. Results: A total of 197 patients were randomised into the study. Skin toxicity was dependent on the treatment group with StrataXRT Ò patients experiencing lower mean skin toxicity at the end of the radiation treatment (P = 0.002). At the end of treatment, the StrataXRT Ò arm had a lower percentage of grade 2 (80%) and grade 3 (28%) skin toxicity compared to the sorbolene arm (91% and 45% respectively). After adjustment for Cetuximab, the StrataXRT Ò arm had a 12% lower risk of experiencing grade 2 skin toxicity (RRR = 0.876, 95% CI: 0.778-0.987, P = 0.031); and a 36% lower risk of experiencing grade 3 skin toxicity (RRR = 0.648, 95% CI: 0.442-0.947, P = 0.025). Cox regression analysis showed that patients receiving StrataXRT Ò had a 41.0% and 49.4% reduced risks of developing grade 2 and 3 skin toxicity respectively throughout treatment compared to the Sorbolene arm. There were no differences between groups in patient-reported outcomes. No treatment interruptions and study product related adverse events were reported in either arm. Conclusion: StrataXRT Ò is effective for preventing, and delaying the development of grade 2 and 3 skin toxicity. Trial registration: ACTRN12616000511437.

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Reducing radiation dermatitis during ongoing radiation therapy: an innovative film-forming wound dressing

Cited by 8 publications

References 10 publications

The Use of an Innovative Film-Forming Wound Dressing in the Treatment of Radiation Dermatitis during Concomitant Chemotherapy

The Use of an Innovative Film-Forming Wound Dressing in the Treatment of Radiation Dermatitis during Concomitant Chemotherapy

Modern Dressings in Prevention and Therapy of Acute and Chronic Radiation Dermatitis—A Literature Review

A single-blind, randomised controlled trial of StrataXRT® – A silicone-based film-forming gel dressing for prophylaxis and management of radiation dermatitis in patients with head and neck cancer

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