Reducing the off-target endocrinologic adverse effects of azole antifungals—can it be done?

Balcerek, Matthew I.; Stewart, Dr Adam G; Chapman, Paul R.; Lazarus, Dr Syndia

doi:10.1016/j.ijantimicag.2022.106587

Cited by 4 publications

(2 citation statements)

References 77 publications

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“…It becomes a universal problem for public health [37,38]. In addition, the widely used antifungal drugs like azoles cause significant side effects and frequently decrease the efficacy against fungal pathogens [39]. For this reason, the discovery of new bioactive compounds with safety and efficacy to treat cancer and microbial infections is an exclusively important objective.…”

Section: Need For Alternative Drugs To Treat Cancer and Microbial Inf...mentioning

confidence: 99%

Antimicrobial and anticancer potential of soil bacterial metabolites - a comprehensive and updated review

Kumar¹,

Kumaresan²

2023

J App Biol Biotech

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The majority of natural products currently used in the medical field are derived from microbial or plant sources. The bioactive compounds derived from natural sources exhibit tremendous structural and chemical diversity. According to previous research, only a small percentage of the world's plant and microbial diversity has been examined for bioactivities. The compounds originating from secondary metabolites of microorganisms are more useful for the development of novel drugs due to their biological friendliness and drug-likeness than any other compounds. Thus, recent research suggests that microorganisms obtained from diverse habitats and natural resources offer various bioactive secondary metabolites with incredibly wider chemical entities, hopefully, an alternative remedy for many diseases. Soil bacteria are capable of producing a variety of natural bioactive compounds for the treatment of various diseases. The three genera Bacillus spp., Streptomyces spp., and Pseudomonas spp. have been the prime focus to produce different types of antibiotics. However, to date, there are no reviews that evaluated the antimicrobial and anticancer properties of soil bacterial metabolites. Hence, the current review aimed to assess the antimicrobial and anticancer potential of soil bacterial metabolites.

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Section: Need For Alternative Drugs To Treat Cancer and Microbial Inf...mentioning

confidence: 99%

Antimicrobial and anticancer potential of soil bacterial metabolites - a comprehensive and updated review

Kumar¹,

Kumaresan²

2023

J App Biol Biotech

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“…The other classes of therapeutically available antifungal drugs are not effective alone to treat fungal co-infections in COVID-19 patients managed in the intensive care unit with prolonged immunomodulatory treatments [ 27 , 28 ] and have caused important side effects [ 29 , 30 ]. Triazoles cause hepatotoxicity, drug–drug interactions, QTc prolongation (the heart muscle takes a comparatively longer time to contract and relax than usual), skeletal fluorosis, pseudohyperaldosteronism, adrenal insufficiency, hyponatremia and hypogonadism [ 29 , 30 ]. The most common complications of echinocandins are thrombophlebitis, hepatotoxicity, derangement of serum transaminases, hypotension and fever, but anemia, leukopenia and thrombocytopenia have also been reported [ 31 , 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Lower Concentrations of Amphotericin B Combined with Ent-Hardwickiic Acid Are Effective against Candida Strains

et al. 2023

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Life-threatening Candida infections have increased with the COVID-19 pandemic, and the already limited arsenal of antifungal drugs has become even more restricted due to its side effects associated with complications after SARS-CoV-2 infection. Drug combination strategies have the potential to reduce the risk of side effects without loss of therapeutic efficacy. The aim of this study was to evaluate the combination of ent-hardwickiic acid with low concentrations of amphotericin B against Candida strains. The minimum inhibitory concentration (MIC) values were determined for amphotericin B and ent-hardwickiic acid as isolated compounds and for 77 combinations of amphotericin B and ent-hardwickiic acid concentrations that were assessed by using the checkerboard microdilution method. Time–kill assays were performed in order to assess the fungistatic or fungicidal nature of the different combinations. The strategy of combining both compounds markedly reduced the MIC values from 16 µg/mL to 1 µg/mL of amphotericin B and from 12.5 µg/mL to 6.25 µg/mL of ent-hardwickiic acid, from isolated to combined, against C. albicans resistant to azoles. The combination of 1 µg/mL of amphotericin B with 6.25 µg/mL of ent-hardwickiic acid killed all the cells of the same strain within four hours of incubation.

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Repurposing anti-osteoporosis drugs for autoimmune diseases: A two-sample Mendelian randomization study

Xiang,

Yang,

Shen

et al. 2024

Heliyon

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Reducing the off-target endocrinologic adverse effects of azole antifungals—can it be done?

Cited by 4 publications

References 77 publications

Antimicrobial and anticancer potential of soil bacterial metabolites - a comprehensive and updated review

Antimicrobial and anticancer potential of soil bacterial metabolites - a comprehensive and updated review

Lower Concentrations of Amphotericin B Combined with Ent-Hardwickiic Acid Are Effective against Candida Strains

Repurposing anti-osteoporosis drugs for autoimmune diseases: A two-sample Mendelian randomization study

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