Reduction in arsenic intake from water has different impacts on lung cancer and bladder cancer in an arseniasis endemic area in Taiwan

Su, Chin-Chuan; Lu, Jia Ling; Tsai, Kuo-Yang; Lian, Ie Bin

doi:10.1007/s10552-010-9679-2

Cited by 25 publications

(10 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In northern Chile, lung cancer rate ratios did not peak until at least 30 years after high exposures began [27] and remain very high (OR = 4.4, 95% CI = 2.6–7.4) nearly 40 years after high exposures ended [28]. Other studies have also found latency periods of 20 years or more [12,16,31,32]. …”

Section: Discussionmentioning

confidence: 99%

Case-Control Study of Arsenic in Drinking Water and Lung Cancer in California and Nevada

Dauphiné

Smith

Yuan

et al. 2013

IJERPH

View full text Add to dashboard Cite

Millions of people are exposed to arsenic in drinking water, which at high concentrations is known to cause lung cancer in humans. At lower concentrations, the risks are unknown. We enrolled 196 lung cancer cases and 359 controls matched on age and gender from western Nevada and Kings County, California in 2002–2005. After adjusting for age, sex, education, smoking and occupational exposures, odds ratios for arsenic concentrations ≥85 µg/L (median = 110 µg/L, mean = 173 µg/L, maximum = 1,460 µg/L) more than 40 years before enrollment were 1.39 (95% CI = 0.55–3.53) in all subjects and 1.61 (95% CI = 0.59–4.38) in smokers. Although odds ratios were greater than 1.0, these increases may have been due to chance given the small number of subjects exposed more than 40 years before enrollment. This study, designed before research in Chile suggested arsenic-related cancer latencies of 40 years or more, illustrates the enormous sample sizes needed to identify arsenic-related health effects in low-exposure countries with mobile populations like the U.S. Nonetheless, our findings suggest that concentrations near 100 µg/L are not associated with markedly high relative risks.

show abstract

Section: Discussionmentioning

confidence: 99%

Case-Control Study of Arsenic in Drinking Water and Lung Cancer in California and Nevada

Dauphiné

Smith

Yuan

et al. 2013

IJERPH

View full text Add to dashboard Cite

show abstract

“…In fact, new studies have shown a decreased risk of bladder cancer after a reduction of arsenic intake from drinking water in Taiwan and Argentina (Su et al, 2011; Pou et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

Interleukin-8 (IL-8) over-production and autocrine cell activation are key factors in monomethylarsonous acid [MMA(III)]-induced malignant transformation of urothelial cells

Escudero‐Lourdes

Camarillo

et al. 2012

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

The association between chronic human exposure to arsenicals and bladder cancer development is well recognized; however, the underlying molecular mechanisms have not been fully determined. We propose that inflammatory responses can play a pathogenic role in arsenic-related bladder carcinogenesis. In previous studies, it was demonstrated that chronic exposure to 50 nM monomethylarsenous acid [MMA(III)] leads to malignant transformation of an immortalized model of urothelial cells (UROtsa), with only 3 mo of exposure necessary to trigger the transformation-related changes. In the three-month window of exposure, the cells over-expressed pro-inflammatory cytokines (IL-1β, IL-6 and IL-8), consistent with the sustained activation of NFKβ and AP1/c-jun, ERK2, and STAT3. IL-8 was over-expressed within hours after exposure to MMA(III), and sustained over-expression was observed during chronic exposure. In this study, we profiled IL-8 expression in UROtsa cells exposed to 50 nM MMA(III) for 1 to 5 mo. IL-8 expression was increased mainly in cells after 3 mo MMA(III) exposure, and its production was also found increased in tumors derived from these cells after heterotransplantation in SCID mice. UROtsa cells do express both receptors, CXCR1 and CXCR2, suggesting that autocrine cell activation could be important in cell transformation. Supporting this observation and consistent with IL-8 over-expression, CXCR1 internalization was significantly increased after three months of exposure to MMA(III). The expression of MMP-9, cyclin D1, bcl-2, and VGEF was significantly increased in cells exposed to MMA(III) for 3 mo, but these mitogen-activated kinases were significantly decreased after IL-8 gene silencing, together with a decrease in cell proliferation rate and in anchorage-independent colony formation. These results suggest a relevant role of IL-8 in MMA(III)-induced UROtsa cell transformation.

show abstract

“…Childhood liver cancer MRRs were 9–14 times higher for those exposed as young children as compared with controls (Liaw et al 2008). Other reports of latency periods extending over 50 years include skin cancer (Haque et al 2003), urinary cancers (Bates et al 2004; Chen CL et al 2010b; Marshall et al 2007; Su et al 2011), and lung cancer (Marshall et al 2007; Su et al 2011). For example, peak SMRs for childhood liver cancer and bronchiectasis were 14.1 and 50.1 times higher, respectively, for individuals exposed to arsenic in utero and during childhood as compared with individuals exposed during other periods of their lives (Table 4) (Smith et al 2006).…”

Section: Varied Susceptibilitiesmentioning

confidence: 99%

The Broad Scope of Health Effects from Chronic Arsenic Exposure: Update on a Worldwide Public Health Problem

Naujokas¹,

Anderson

Ahsan

et al. 2013

Environ Health Perspect

1,132

616

View full text Add to dashboard Cite

Background: Concerns for arsenic exposure are not limited to toxic waste sites and massive poisoning events. Chronic exposure continues to be a major public health problem worldwide, affecting hundreds of millions of persons.Objectives: We reviewed recent information on worldwide concerns for arsenic exposures and public health to heighten awareness of the current scope of arsenic exposure and health outcomes and the importance of reducing exposure, particularly during pregnancy and early life.Methods: We synthesized the large body of current research pertaining to arsenic exposure and health outcomes with an emphasis on recent publications.Discussion: Locations of high arsenic exposure via drinking water span from Bangladesh, Chile, and Taiwan to the United States. The U.S. Environmental Protection Agency maximum contaminant level (MCL) in drinking water is 10 µg/L; however, concentrations of > 3,000 µg/L have been found in wells in the United States. In addition, exposure through diet is of growing concern. Knowledge of the scope of arsenic-associated health effects has broadened; arsenic leaves essentially no bodily system untouched. Arsenic is a known carcinogen associated with skin, lung, bladder, kidney, and liver cancer. Dermatological, developmental, neurological, respiratory, cardiovascular, immunological, and endocrine effects are also evident. Most remarkably, early-life exposure may be related to increased risks for several types of cancer and other diseases during adulthood.Conclusions: These data call for heightened awareness of arsenic-related pathologies in broader contexts than previously perceived. Testing foods and drinking water for arsenic, including individual private wells, should be a top priority to reduce exposure, particularly for pregnant women and children, given the potential for life-long effects of developmental exposure.

show abstract

Reduction in arsenic intake from water has different impacts on lung cancer and bladder cancer in an arseniasis endemic area in Taiwan

Cited by 25 publications

References 21 publications

Case-Control Study of Arsenic in Drinking Water and Lung Cancer in California and Nevada

Case-Control Study of Arsenic in Drinking Water and Lung Cancer in California and Nevada

Interleukin-8 (IL-8) over-production and autocrine cell activation are key factors in monomethylarsonous acid [MMA(III)]-induced malignant transformation of urothelial cells

The Broad Scope of Health Effects from Chronic Arsenic Exposure: Update on a Worldwide Public Health Problem

Contact Info

Product

Resources

About