Reduction in cortical IMP-SPET tracer uptake with recent cigarette consumption in a young group of healthy males

Rourke, Sean B.; Dupont, Renee M.; Grant, Igor; Lehr, Patricia P.; Lamoureux, Guy; Halpern, Samuel E.; Yeung, David W.C.; HIV, San Diego Neurobehavioral Research Center

doi:10.1007/s002590050072

Cited by 11 publications

(11 citation statements)

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“…This interpretation is supported by neuroimaging studies indicating a decreased cerebral blood flow in smokers, which may improve following the cessation of smoking (Meyer et al 1995;Rourke et al 1997). …”

Section: Discussionmentioning

confidence: 85%

The P300 brain potential is reduced in smokers

Anokhin¹,

Vedeniapin²,

Sirevaag³

et al. 2000

Psychopharmacology

117

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Rationale: Tobacco smoking is the most prevalent type of substance abuse, yet its biobehavioral etiology is little understood. Identification of differences between smokers and non-smokers on basic characteristics of neurocognitive functioning may help to elucidate the mechanisms of tobacco dependence. Objectives: This study assessed the relationship between smoking status and the P300 component of event-related potential (ERP) while controlling for potential confounders such as alcoholism, drug abuse, and psychopathology. Methods: The ERP responses elicited by a visual oddball task were measured at the mid-parietal site in 905 current smokers, 463 ex-smokers, and 979 never smokers. Results: P300 amplitude was significantly lower in current cigarette smokers compared to never-smokers. Exsmokers did not differ significantly from never-smokers. P300 reduction was also associated with alcoholism, drug dependence, and family density of alcoholism. However, after controlling for smoking, only family density of alcoholism remained a significant predictor of P300 amplitude. Conclusions: The results indicate a significant effect of smoking status on P300 amplitude which is additive to family history of alcoholism and suggest that either (1) long-term tobacco smoking may produce a reversible change in brain function, or (2) reduced P300 may be a marker of risk for nicotine dependence.

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Section: Discussionmentioning

confidence: 85%

The P300 brain potential is reduced in smokers

Anokhin¹,

Vedeniapin²,

Sirevaag³

et al. 2000

Psychopharmacology

117

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“…Prolonged lung retention of IMP in pulmonary disease [21] and smokers [22] are known, there may be some mis-estimations of regional CBF values by this graph plot method in pulmonary disease patients or heavy smokers.…”

Section: Discussionmentioning

confidence: 98%

Regional cerebral blood flow in healthy volunteers measured by the graph plot method with iodoamphetamine SPECT

et al. 2010

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“…The SPECT studies by Yamamoto et al (2003) and Rourke et al (1997) and the PET study by Rose et al (1998) described a decline in global CBF after smoking, too (Rourke et al, 1997;Stapleton et al, 2003;Yamamoto et al, 2003). Shinohara et al (2006) found with PET no significant changes in global CBF after NIC administration (smoking) in smokers, however they found a statistically significant inverse correlation between arterial NIC concentrations and CBF (Shinohara et al, 2006).…”

Section: The Effects Of Nicotine On Brain Activitymentioning

confidence: 92%