The sprout seeds used for human consumption are the suspect carrier of bacterial pathogens (Salmonella and Escherichia coli O157:H7), which can cause sprout related food borne illnesses. In 2000, irradiation to doses up to 8 kGy was approved for sprout seeds as a control. Literature exists on the effect of radiation to reduce pathogens on meat and poultry products; however, literature on pathogen reduction on seeds and sprouts by ionizing radiation is limited. Review of the research results on irradiated seeds indicates that each seed variety's germination and growth are affected differently by irradiation.Under the disinfection ruling, irradiation is approved up to 1 kGy for vegetable but not for pathogen reduction. There is a petition for ready-to-eat foods that would permit the use of irradiation to a maximum dose of 4.5 kGy on fresh sprouts. Research has shown that the irradiation process is a promising technology to increase shelf-life of fresh vegetables and sprouts and reduce bacterial pathogen contamination. Future areas of research are outlined for both raw sprout and sprout seeds to identify the approach of providing a safer product for the consumer.