Reduction in noise-induced temporary threshold shift in humans following oral magnesium intake

Attias, Joseph; Sapir, Shimon; Bresloff, I; Reshef-Haran, I.; Ising, H

doi:10.1111/j.1365-2273.2004.00866.x

Cited by 81 publications

(50 citation statements)

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“…That exogenous antioxidant agents reduce sensory cell death and NIHL has been well demonstrated in animal studies using a variety of free radical scavengers [24,[44][45][46][47][48][49][50][51][52][53][54][55][56], including several studies with dietary antioxidants [50,[57][58][59][60]. Magnesium supplements also reduce NIHL [61][62][63][64][65][66][67][68][69].Given the potential for synergy of multiple agents in protection from neurodegenerative-cell death, in this investigation, we evaluated protection from NIHL and noise-induced sensory cell death with the combination of vitamins A, C, and E, or magnesium, or vitamins A, C, and E, plus magnesium. Each of these agents has a distinct mechanism of action.…”

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confidence: 99%

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Prell

Hughes

Miller

2007

Free Radical Biology and Medicine

201

188

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Free radical formation in the cochlea plays a key role in the development of noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant formation of both reactive oxygen species and reactive nitrogen species 7-10 days following noise exposure. Reduction in cochlear blood flow as a result of free radical formation has also been described. Here we report that the antioxidant agents, vitamins A, C, and E, act in synergy with magnesium to effectively prevent noise-induced trauma. Neither the antioxidant agents nor magnesium reliably reduced NIHL or sensory cell death with the doses we used when these agents were delivered alone. In combination, however, they were highly effective in reducing both hearing loss and cell death even with treatment initiated just one hour prior to noise exposure. This study supports roles for both free radical formation and noise-induced vasoconstriction in the onset and progression of NIHL. Identification of this safe and effective antioxidant intervention that attenuates NIHL provides a compelling rationale for human trials in which free radical scavengers are used to eliminate this single major cause of acquired hearing loss. Keywords cochlea; free radical; noise; hearing; antioxidant; vasodilation Mechanical destruction of cells in the organ of Corti was once assumed to be the primary cause of noise-induced hearing loss (NIHL) [1][2][3][4][5][6][7][8], with perhaps some effect of reduced blood flow to the inner ear [9][10][11][12][13][14][15][16][17][18]. We now know that another key factor is intense metabolic activity that results in production of excess free radicals [19][20][21][22][23] and lipid peroxidation products [24]. Noise-induced production of reactive oxygen species (ROS) in the cochlea has now been well characterized, and several recent reviews are available [25][26][27]. Mitochodrial dysfunction and ROS production have been implicated in numerous neurodegenerative syndromes and diseases [28-34, see 35,36]. The use of antioxidant agents holds significant therapeutic promise for many neurodegenerative processes [32,33,[37][38][39][40][41][42], and there is some suggestion that Correspondence to: C. G. Le Prell, Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USA. Tel: +1-734-763-5104; fax +1-734-764-0014. E-mail address: colleeng@umich.edu. Disclosure. Dr. Miller is a founding member and Chairman of the Board of Directors at OtoMedicine, Inc., a company that has an option to license the intellectual property described in this report. Dr. Le Prell is a paid consultant to OtoMedicine, Inc. Drs. Miller and Le Prell have disclosed these relationships to the Medical School Conflict of Interest Board at the University of Michigan; conflict management plans including semi-annual review by the Board are in place.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publicatio...

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confidence: 99%

Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma

Prell

Hughes

Miller

2007

Free Radical Biology and Medicine

201

188

View full text Add to dashboard Cite

show abstract

“…This was interesting because on the one hand, magnesium supplementation appeared to offer protection in soldiers in terms of the severity of TTS. In a laboratory-based human subject study, no significant changes were noted in serum Mg levels between noise-exposed individuals and controls (Attias et al 2004 ). Bearing in mind that Mg levels in the serum can be measured with diffi culty and with less than desirable reliability, the relationship between magnesium supplementation and protection from NIHL, while provocative, needs to be investigated further.…”

Section: Magnesiummentioning

confidence: 96%

Antioxidants and Their Effect on Stress-Induced Pathology in the Inner Ear

Shirwany¹,

Seidman

2015

Free Radicals in ENT Pathology

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“…Otoacoustic emission (OAE) provides the possibility of early diagnosis of noise induced hearing loss and is considered to be a very promising tool to detect mild hearing loss in exposed subjects (14-16) compared to pure tone audiometry (PTA) (17)(18)(19)(20)(21). Transiently evoked otoacoustic emission (TEOAE) is a sensitive, objective and frequency specific audiometric test for evaluating early hair cell damage (10,11,(13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%