No abstract

A previous study demonstrated the prophylactic effects of magnesium on noise-induced permanent threshold shift in humans. For the first time, this study explores the effects of magnesium on temporary threshold shift in 20 human subjects, all men (16-37 years, mean age 21 years). The study was conducted in a double-blind manner on the same subjects tested in three different phases (placebo, magnesium, no-drug). The cochlear changes were assessed using both behavioural (audiograms) and objective (otoacoustic emission) measures. Blood samples were collected at the beginning and end of each phase. Amongst subjects and phases, magnesium intake was associated with significantly lower temporary threshold shift, compared with the other two phases, which were reflected both by the behavioural and cochlear measures. A correlation was found between the blood magnesium levels and temporary threshold shift reduction. No side-effects were associated with the oral ingestion of the magnesium. Magnesium provides significant protection against temporary threshold shift, complementing the previous permanent threshold shift human study. Both human noise-induced hearing loss studies introduced a novel, biological, natural agent for prevention and possible treatment of noise-induced cochlear damage in humans.

Click evoked otoacoustic emissions (CEOAEs) are an objective and reliable method of assessing cochlear status, particularly suitable for newborns. This study aimed to assess CEOAE inter-aural and gender differences. Other non-auditory factors, such as infant's head size and weight, were considered. Band averaged CEOAEs were analyzed for 120 healthy, full term newborns, 61 females and 59 males. The babies were randomly selected from the nursery and tested in a quiet room away from the ward, using an Otodynamic ILO 92 system. The CEOAEs of the females were significantly larger than those of the males. For the frequency bands 2, 3, and 4 kHz and for the overall response, the emissions were larger in the right ear, for both males and females. These inter-aural differences were more pronounced in male subjects than in female subjects. These findings may reflect the accumulating evidence that differences exist in efferent cochlear inhibition.