“…However, while these coatings have proven effective at reducing the incidence of spasm and improving patient comfort, the use of hydrophilic sheaths does not appear to prevent the reduction in flow mediated dilation, an index of endothelial dysfunction [9], and did not markedly influence the incidence of radial occlusion [10,11]. Further, the use of certain hydrophilic coatings (for example, those manufactured by Cook [12,13]) has been associated with the formation of sterile granulomas and abscesses [14][15][16][17][18].…”