Reduction in Toxicity of Nano-Ag-Polyvinyl-pyrrolidone Using Hydra Proteins and Peptides during Zebrafish Embryogenesis

Kim, Soon-Seok; Lee, Jin Ah; Yeo, Min‐Kyeong

doi:10.3390/nano9091210

Cited by 5 publications

(3 citation statements)

References 62 publications

(73 reference statements)

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“…These results further support the leading role of surface coating in AgNP environmental safety and highlight the need to focus research efforts on the investigation of the main features involved in AgNP ecotoxicity, in order to allow the production of ecologically safe ENMs for environmental applications. Furthermore, recent findings [25,26,35,36] have demonstrated that peptides extracted from Hydra basal disks, which are involved in the organism's defense against bacterial attacks, show a natural ability to counteract AgNP toxicity towards different organisms and cells. Further investigations are thus encouraged to better understand the mechanisms behind such an ability for future biotechnological applications.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, recent findings [25,26,35,36] have demonstrated that peptides extracted from Hydra basal disks, which are involved in the organism's defense against bacterial attacks, show a natural ability to counteract AgNP toxicity towards different organisms and cells. Further investigations are thus encouraged to better understand the mechanisms behind such an ability for future biotechnological applications.…”

Section: Ecotoxicitymentioning

confidence: 99%

“…Interestingly, recent findings show that extracts from Hydra sp. basal discs, which contain antimicrobial peptides (AMP) and are involved in innate immune defense, reduce the toxicity of polyvinylpyrrolidone (PVP)-coated AgNPs to bacteria and zebrafish [25,26].…”

Section: Introductionmentioning

confidence: 99%

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Sensitivity of Hydra vulgaris to Nanosilver for Environmental Applications

Bellingeri

Battocchio

Faleri

et al. 2022

Toxics

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Nanosilver applications, including sensing and water treatment, have significantly increased in recent years, although safety for humans and the environment is still under debate. Here, we tested the environmental safety of a novel formulation of silver nanoparticles functionalized with citrate and L-cysteine (AgNPcitLcys) on freshwater cnidarian Hydra vulgaris as an emerging ecotoxicological model for the safety of engineered nanomaterials. AgNPcitLcys behavior was characterized by dynamic light scattering (DLS), while Ag release was measured by inductively coupled plasma mass spectrometry (ICP-MS). H. vulgaris (n = 12) subjects were evaluated for morphological aberration after 96 h of exposure and regeneration ability after 96 h and 7 days of exposure, after which the predatory ability was also assessed. The results show a low dissolution of AgNPcitLcys in Hydra medium (max 0.146% of nominal AgNPcitLcys concentration) and highlight a lack of ecotoxicological effects, both on morphology and regeneration, confirming the protective role of the double coating against AgNP biological effects. Predatory ability evaluation suggests a mild impairment of the entangling capacity or of the functionality of the tentacles, as the number of preys killed but not ingested was higher than the controls in all exposed animals. While their long-term sub-lethal effects still need to be further evaluated on H. vulgaris, AgNPcitLcys appears to be a promising tool for environmental applications, for instance, for water treatment and sensing.

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Section: Discussionmentioning

confidence: 99%