Reduction of Carryover of Aflatoxin from Cow Feed to Milk by Addition of Activated Carbons

Abstract

According to a double-reversal experimental design on 12 late-lactation Friesian cows the effect of two activated carbons (ACs) (CAC1 and CAC2) and a hydrated sodium calcium aluminosilicate (HSCAS) on carryover of aflatoxin B1 (AFB1) from feed to aflatoxin M1 (AFM1) in milk was determined. Cows were fed a basal diet containing AFB1 naturally contaminated corn meal and copra, During week 1 cows were fed diets containing AFB1 alone (11.28 μg of AFB1/kg of feed); in week 2 the diets contained AFB1 plus 2.0% sorbent; and in week 3 the diets again contained AFB1 alone (13.43 μg of AFB1/kg of feed). ACs reduced the analytical content of AFB1 in the pelleted feed by from 40.6% to 73.6%, whereas reduction by HSCAS was 59.2%, The AFM1 concentrations in milk in weeks 1 and 3 were higher than that in week 2, Decreases in the AFM1 excreted in the milk by addition to feed of 2% of the sorbents ranged from 22% to 45%. CAC1 and HSCAS were significantly different from each other in reducing the AFM1concentration in milk (45.3% versus 32.5%); these reductions were significantly higher than that of CAC2 (22.0%). Carryover reduction by addition of CAC1 (50%) was significantly higher than that of HSCAS (36%). Addition of 2% CAC2 did not allow pelleting of feed because of the caking action of this carbon, The lower performance of CAC2 could be related to the unsuccessful pelleting. The addition of ACs did not influence feed intake, milk production, milk composition, or body weight. Our results suggest that ACs, high-affinity sorbents for AFB1 in vitro, are efficacious in reducing AFB1 carryover from cow feed to milk. Further in vivo investigations should establish lower amounts of ACs which can be efficacious.

Aflatoxin M1 in Nili-ravi buffaloes and its detoxification using organic and inorganic toxin binders

“…This is in accordance with Murthy and Devegowda (2004) who reported that modified glucomannan readily adsorb several mycotoxins better than inorganic binders in broilers. Similarly a 36 % reduction in carry over from AFB1 in feed to AFM1 in milk was reported in an in vivo study by Galvano et al (1996). Akhtar et al (2014) also reported its better efficacy in terms of improved hematological and biochemical parameters.…”

Responses of Nili-Ravi buffalo to aflatoxin B1 with and without toxin adsorbents

“…Previous studies have shown its effect at a high dose in goats (Hatch et al, 1982), other studies report variable results. Galvano et al (1996) showed reduced aflatoxin residues in the milk of cows consuming different sources of charcoal, but responses to charcoal did not exceed those to HSCAS. This is in line with our findings.…”

Survey of the occurrence of Aflatoxin M1 in ovine milk by HPLC and its confirmation by MS

“…Variability is due to different factors such as individual response, AFB 1 intake level, stage and order of lactation [10]. Literature data about AFB 1 carry over in dairy ewes milk are very scarce.…”

“…In lactating animals the conversion rate of AFB 1 to AFM 1 ranges between 0.5 and 6% [10]. Variability is due to different factors such as individual response, AFB 1 intake level, stage and order of lactation [10].…”