Reduction of endometriosis-related pain: efficacy of trace elements in a double-blind, randomized, placebo-controlled trial

Marès, P.; Pivano, Audrey; Cophignon, Auréa; Urbinelli, Renaud; Agostini-Ferrandes, Aubert

doi:10.23736/s0026-4784.20.04538-4

Cited by 4 publications

(18 citation statements)

References 2 publications

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“…Figure 1 shows the PRISMA flow diagram (see Supplementary File 2 for excluded studies). Fifteen studies (n = 1093; 660 allocated to intervention; 759 to comparator) were eligible for this review (Table 1), including eight randomised controlled trials (RCT) [29][30][31][32][33][34][35][36][37][38], two observational case series [39,40], one non-randomised comparative trial [41], one cross-over trial [42], and one pre-post intervention trial [43].…”

Section: Study Selection and Characteristics Of Included Studiesmentioning

confidence: 99%

“…Three studies used a numeric pain rating scale (0 -3) [29,42,43]. Quality of life was assessed using a range of self-report questionnaires, including the Endometriosis Health Profile (EHP) -30 [34,37], the 36-Item Short Form Survey (SF-36) [30], and the 12-Item Short Form Survey (SF-12) [38]. For follow-up, 13 studies assessed outcome measures at end of intervention [29,[31][32][33][34][35][36][37][38][39][40][41][42].…”

Section: Outcome Measures and Follow-upmentioning

confidence: 99%

“…Quality of life was assessed using a range of self-report questionnaires, including the Endometriosis Health Profile (EHP) -30 [34,37], the 36-Item Short Form Survey (SF-36) [30], and the 12-Item Short Form Survey (SF-12) [38]. For follow-up, 13 studies assessed outcome measures at end of intervention [29,[31][32][33][34][35][36][37][38][39][40][41][42]. Three studies assessed outcomes at additional follow-up time points, ranging from four weeks to six months post-intervention [30,36,43].…”

Section: Outcome Measures and Follow-upmentioning

confidence: 99%

“…Of the 11 randomised trials, seven were assessed as high risk [29,30,34,[36][37][38]40], and four with some concerns [31][32][33]35] (Table 2). Common reasons for risk of bias were randomisation methods (n= 4) and concealment of intervention allocation (n = 4).…”

Section: Randomised Studiesmentioning

confidence: 99%

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The Efficacy of Self-Management Strategies for Females with Endometriosis: a Systematic Review

et al. 2022

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Self-management is critical for the care of endometriosis. Females with endometriosis frequently use self-management strategies to manage associated symptoms; however, the efficacy of such strategies is unknown. The aim of this review was to systematically appraise the evidence concerning efficacy of self-management strategies for endometriosis symptoms. Electronic databases, including Medline, Embase, Emcare, Web of Science Core Collection, Scopus, and the Cochrane Central Register of Controlled Trials, were searched from inception to March 2021. We included peer-reviewed experimental studies published in English evaluating the efficacy of self-management strategies in human females laparoscopically diagnosed with endometriosis. Studies underwent screening, data extraction, and risk of bias appraisal (randomised studies: Risk of Bias 2 tool; non-randomised studies: Risk Of Bias In Non-randomized Studies – of Interventions tool). Of the fifteen studies included, 10 evaluated dietary supplements, three evaluated dietary modifications, one evaluated over-the-counter medication, and one evaluated exercise. Most studies had a high-critical risk of bias. Many self-management strategies were not more effective at reducing endometriosis symptoms compared to placebo or hormonal therapies. Where studies suggest efficacy for self-management strategies, no recommendations can be made due to the poor quality and heterogeneity of evidence. High-quality empirical evidence is required to investigate the efficacy of self-management strategies for females with endometriosis.

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Section: Study Selection and Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Outcome Measures and Follow-upmentioning

confidence: 99%

Section: Outcome Measures and Follow-upmentioning

confidence: 99%

Section: Randomised Studiesmentioning

confidence: 99%

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The Efficacy of Self-Management Strategies for Females with Endometriosis: a Systematic Review

et al. 2022

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“…It has been demonstrated that the gastrointestinal absorption of both Pb and Cd increases in women with depleted stores of iron, calcium, and zinc [ 112 , 113 ]. Moreover, important bleedings associated with endometriosis may conceivably contribute to an additional depletion of the iron stores and, in turn, facilitate Cd or Pb absorption [ 114 ].…”

Section: Trace Elements and Endometriosismentioning

confidence: 99%

Brief Review of Endometriosis and the Role of Trace Elements

Osuchowska-Grochowska

Blicharska

Gogacz

et al. 2021

IJMS

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Endometriosis is a chronic, estrogen-dependent, inflammatory condition that is defined as the presence of endometrial glands and stroma outside the uterine cavity. Despite the progress in research into the mechanisms leading to the development of endometriosis, its cause has not yet been established. It seems to be possible that the formation of oxidative stress may be one of the main causes of the development of endometriosis. There is much research that studies the potential role of trace elements in the appearance of endometrial-like lesions. Most studies focus on assessing the content of selected trace elements in the blood, urine, or peritoneal fluid in women with endometriosis. Meanwhile, little is known about the content of these elements in endometrial-like implants, which may be helpful in developing the theory of endometriosis. Investigations that are more comprehensive are needed to confirm a hypothesis that some trace elements play a role in the pathomechanism of endometriosis.

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Effects of trace element dietary supplements on voice parameters and some physiological and psychological parameters related to stress

Soula,

Messas,

Aridhi

et al. 2024

Heliyon

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Reduction of endometriosis-related pain: efficacy of trace elements in a double-blind, randomized, placebo-controlled trial

Cited by 4 publications

References 2 publications

The Efficacy of Self-Management Strategies for Females with Endometriosis: a Systematic Review

The Efficacy of Self-Management Strategies for Females with Endometriosis: a Systematic Review

Brief Review of Endometriosis and the Role of Trace Elements

Effects of trace element dietary supplements on voice parameters and some physiological and psychological parameters related to stress

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