Reduction of HbA1c levels following nonsurgical treatment of periodontal disease in type 2 diabetics

Montoya-Carralero, Josè Ma; Saura-Pérez, Manuel; Canteras-Jordana, Manuel; Morata-Murcia, Isabel Ma

doi:10.4317/medoral.15.e808

Cited by 21 publications

(21 citation statements)

References 15 publications

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“…The presence of periodontitis increases the risk of worsening of glycemic control over time (11). It has been proposed that PD could initiate or propagate insulin resistance in a similar manner to that of obesity, by enhancing activation of the overall systemic immune response initiated by cytokines (5).…”

Section: Possible Effect Of Periapical Infection On Diabetes Mellitusmentioning

confidence: 99%

“…Likewise, the mechanisms of the host-mediated response in PD involve activation of the broad axis of innate immunity, specifically by up-regulation of proinflammatory cytokines from monocytes and polymorphonuclear leukocytes. Thus, chronic gram-negative periodontal infections may induce or perpetuate an elevated chronic systemic inflammatory status, contributing to increased insulin resistance and poor glycemic control (11). …”

Section: Possible Effect Of Periapical Infection On Diabetes Mellitusmentioning

confidence: 99%

“…Thus, PD has been associated to diabetes mellitus (DM) (4,5), coronary heart disease (CHD) (6) and acute myocardial infarction (AMI) (7), preterm-low birth weight (8), respiratory diseases (9) and osteoporosis in post-menopause women (10). The evidence of the association between PD and systemic diseases has increased the attention at the diagnosis and treatment of PD, improving, consequently, the patient’s oral and systemic health (11). …”

Section: Introductionmentioning

confidence: 99%

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Diabetes mellitus, periapical inflammation and endodontic treatment outcome

Segura-Egea¹,

Castellanos-Cosano²,

Machuca³

et al. 2012

Med Oral

125

106

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The possible connection between chronic oral inflammatory processes, such as apical periodontitis and periodontal disease (PD), and systemic health is one of the most interesting aspects faced by the medical and dental scientific community. Chronic apical periodontitis shares important characteristics with PD: 1) both are chronic infections of the oral cavity, 2) the Gram-negative anaerobic microbiota found in both diseases is comparable, and 3) in both infectious processes increased local levels of inflammatory mediators may have an impact on systemic levels. One of the systemic disorders linked to PD is diabetes mellitus (DM); is therefore plausible to assume that chronic apical periodontitis and endodontic treatment are also associated with DM. The status of knowledge regarding the relationship between DM and endodontics is reviewed. Upon review, we conclude that there are data in the literature that associate DM with a higher prevalence of periapical lesions, greater size of the osteolityc lesions, greater likelihood of asymptomatic infections and worse prognosis for root filled teeth. The results of some studies suggest that periapical disease may contribute to diabetic metabolic dyscontrol. Key words: Apical periodontitis, diabetes mellitus, endodontics, root canal treatment.

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Section: Possible Effect Of Periapical Infection On Diabetes Mellitusmentioning

confidence: 99%

Section: Possible Effect Of Periapical Infection On Diabetes Mellitusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diabetes mellitus, periapical inflammation and endodontic treatment outcome

Segura-Egea¹,

Castellanos-Cosano²,

Machuca³

et al. 2012

Med Oral

125

106

View full text Add to dashboard Cite

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“…Therefore, periapical chronic inflammation could induce or perpetuate an elevated chronic systemic inflammatory status, contributing to increased insulin resistance and poor glycaemic control (Montoya‐Carralero et al . , Segura‐Egea et al . ).…”

Section: Association Between Endodontics and Diabetes Mellitusmentioning

confidence: 99%

“…Similarly, the mechanisms of the host-mediated response in AP involve activation of the broad axis of innate immunity, specifically by up-regulation of pro-inflammatory cytokines from monocytes and polymorphonuclear leucocytes. Therefore, periapical chronic inflammation could induce or perpetuate an elevated chronic systemic inflammatory status, contributing to increased insulin resistance and poor glycaemic control (Montoya-Carralero et al 2010, Segura-Egea et al 2012. The action of inflammatory mediators released in periapical inflammation could be associated with the development of insulin resistance, which is influenced by genetically modified environmental factors, including decreased physical activity, poor nutrition, obesity and infection (Pickup 2004, Segura-Egea et al 2012, 2013, 2014.…”

Section: Biological Mechanisms Linking Periapical Status and Diabetesmentioning

confidence: 99%

Endodontic medicine: connections between apical periodontitis and systemic diseases

2015

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The prevalence of apical periodontitis (AP) in Europe has been reported to affect 61% of individuals and 14% of teeth, and increase with age. Likewise, the prevalence of root canal treatment (RCT) in Europe is estimated to be around 30-50% of individuals and 2-9% of teeth with radiographic evidence of chronic persistent AP in 30-65% of root filled teeth (RFT). AP is not only a local phenomenon and for some time the medical and dental scientific community have analysed the possible connection between apical periodontits and systemic health. Endodontic medicine has developed, with increasing numbers of reports describing the association between periapical inflammation and systemic diseases. The results of studies carried out both in animal models and humans are not conclusive, but suggest an association between endodontic variables, that is AP and RCT, and diabetes mellitus (DM), tobacco smoking, coronary heart disease and other systemic diseases. Several studies have reported a higher prevalence of periapical lesions, delayed periapical repair, greater size of osteolityc lesions, greater likelihood of asymptomatic infections and poorer prognosis for RFT in diabetic patients. On the other hand, recent studies have found that a poorer periapical status correlates with higher HbA1c levels and poor glycaemic control in type 2 diabetic patients. However, there is no scientific evidence supporting a causal effect of periapical inflammation on diabetes metabolic control. The possible association between smoking habits and endodontic infection has also been investigated, with controversial results. The aim of this paper was to review the literature on the association between endodontic variables and systemic health (especially DM and smoking habits).

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Endodontics in Systemically Compromised Patients

Wynne

2017

Common Complications in Endodontics

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Reduction of HbA1c levels following nonsurgical treatment of periodontal disease in type 2 diabetics

Cited by 21 publications

References 15 publications

Diabetes mellitus, periapical inflammation and endodontic treatment outcome

Diabetes mellitus, periapical inflammation and endodontic treatment outcome

Endodontic medicine: connections between apical periodontitis and systemic diseases

Endodontics in Systemically Compromised Patients

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