Among the several sources of acoustic annoyance produced by rotorcraft in operating conditions, blade-vortex interactions (BVIs) capture the interest of much of the current research. This paper deals with the reduction of BVI noise from helicopter main rotors by application of the active twist rotor concept (ATR), exploiting smart materials for twisting blades through higher-harmonic torque loads. An optimal, multi-cyclic, control approach is applied to identify the control law driving the ATR actuation during the occurrence of severe BVI events. Numerical predictions are obtained through a computational tool that is able to predict the aeroelastic response of the rotor blades and the emitted noise in arbitrary steady flight conditions. The approach for the control law identification is described and numerical results concerning aeroelastic and aeroacoustic performance of the controlled rotor are presented to assess the proposed methodology.