Reduction of Langerhans Cells in Human Epidermis during PUVA Therapy: A Morphometric Study

Ree, Kristian

doi:10.1111/1523-1747.ep12510257

Cited by 45 publications

(9 citation statements)

References 21 publications

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“…In several studies the number of LC in lesional or noninvolved skin of psoriatic patients was reduced or almost depleted after systemic PUVA treatment in several studies [15,[30][31][32][33][34][35][36]. Similar effects were noted after PUVA-bath therapy (both using trimethylpsoralen and methoxypsoralen) [14,35,37] which resulted in a decrease in LCs number in psoriatic epidermis.…”

Section: Discussionmentioning

confidence: 83%

Clinical immunology Density of Langerhans cells in chronic plaque psoriatic lesions before and after phototherapy

Rotsztejn¹,

Chomiczewska²,

Trznadel-Grodzka³

et al. 2012

cejoi

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Section: Discussionmentioning

confidence: 83%

Clinical immunology Density of Langerhans cells in chronic plaque psoriatic lesions before and after phototherapy

Rotsztejn¹,

Chomiczewska²,

Trznadel-Grodzka³

et al. 2012

cejoi

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“…It was previously reported that UV induces not only DNA damage in T-cells but also emigration of T-cells from the skin. [101112] However, clinical trials of PUVA and NBUVB treatments for AA have been conducted with variable results. [5678] These therapies are thought to be disadvantageous because large unaffected areas are irradiated along with the AA lesions, resulting in insufficient increment of irradiation dose at lesional skin sites.…”

Section: Resultsmentioning

confidence: 99%

308-nm excimer lamp for the treatment of alopecia areata: Clinical trial on 16 cases

et al. 2013

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Background:Alopecia areata (AA) is considered as a T-cell mediated autoimmune disorder. The 308-nm excimer laser is thought to be capable of inducing T-cell apoptosis in vitro, suggesting that the 308-nm excimer lamp (not laser) might be effective for the treatment of AA. We examined the effectiveness of the 308-nm excimer lamp for treating AA.Materials and Methods:We treated 16 patients with single AA and multiple AA (MAA). The lesions were irradiated with a 308-nm excimer lamp at 2-week intervals.Results:Hair regrowth was observed in 14 patients. Among them, 10 patients showed more than 50% hair re-growth. Our results suggested that the 308-nm excimer lamp system is effective and safe for the treatment of single AA and MAA.Conclusion:Our results suggest that the 308-nm excimer lamp is a good therapeutic alternative without serious side effect for treating AA.

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“…It is well known that PUVA photochemotherapy (20) and topical use of glucocorticoid drugs (21,22) markedly deplete epidermal Langerhans cells and enhance the rate of repigmentation in patients with nonsegmental type vitiligo. It is well known that PUVA photochemotherapy (20) and topical use of glucocorticoid drugs (21,22) markedly deplete epidermal Langerhans cells and enhance the rate of repigmentation in patients with nonsegmental type vitiligo.…”

Section: Discussionmentioning

confidence: 99%

“…In the repigmenting group of patients with vitiligo, the Langerhans cells were markedly depleted in the repigmented skin. It is well known that PUVA photochemotherapy (20) and topical use of glucocorticoid drugs (21,22) markedly deplete epidermal Langerhans cells and enhance the rate of repigmentation in patients with nonsegmental type vitiligo. Thus it is proposed that various methods of treatment which deplete epidermal Langerhans cells may help repigmentation in nonsegmental type vitiligo.…”

Section: Discussionmentioning

confidence: 99%

Depletion and Repopulation of Langerhans Cells in Nonsegmental Type Vitiligo

Kao

1990

The Journal of Dermatology

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The role of Langerhans cells in the pathogenesis of nonsegmental type vitiligo is still unknown. In this study, biopsies were taken from 26 patients at various stages of nonsegmental type vitiligo and morphometrically observed to investigate the kinetics of Langerhans cells in patients at various stages of the disease. A marked depletion of OKT6-positive and ATPase-positive epidermal dendritic cells was noted in patients with active nonsegmental type vitiligo. A repopulation of both OKT6-positive and ATPase-positive epidermal dendritic cells was noted in patients with stable nonsegmental type vitiligo. Profound depletion of epidermal OKT6-positive and ATPase-positive dendritic cells was noted in patients with repigmenting nonsegmental type vitiligo receiving treatments involving topical use of 0.05% Fluocinonide cream or PUVA photochemotherapy. Transmission electron microscopy confirmed the absence of epidermal dendritic cells (Langerhans cells and intermediate cells) in patients with active and repigmenting nonsegmental type vitiligo. In active nonsegmental type vitiligo, two possible explanations are proposed for the depletion of OKT6-positive and ATPase-positive epidermal dendritic cells (presumptive Langerhans cells): 1) the cells are destroyed by cytotoxic factors released during the course of destruction of melanocytes in active vitiligo, and/or 2) they leave the epidermis and migrate to regional lymph nodes to present certain antigens which are released from certain destroyed epidermal cells (keratinocytes or melanocytes) during the course of active vitiligo. The repopulated epidermal Langerhans cells may result from phenotypically transformed dermal dendritic cells in the depigmented lesions of patients with stable vitiligo. Since various therapies which result in repigmentation deplete the density of epidermal Langerhans cells markedly, it is suggested that depletion of epidermal Langerhans cells in stable vitiligo may aid in repigmentation. It is also proposed that the repopulated epidermal Langerhans cells may play a role in inhibiting the proliferation of epidermal melanocytes in depigmented lesions of stable vitiligo, thus various methods of treatment which deplete the Langerhans cells may eventually aid in the repigmentation of nonsegmental type vitiligo.

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Reduction of Langerhans Cells in Human Epidermis during PUVA Therapy: A Morphometric Study

Cited by 45 publications

References 21 publications

Clinical immunology Density of Langerhans cells in chronic plaque psoriatic lesions before and after phototherapy

Clinical immunology Density of Langerhans cells in chronic plaque psoriatic lesions before and after phototherapy

308-nm excimer lamp for the treatment of alopecia areata: Clinical trial on 16 cases

Depletion and Repopulation of Langerhans Cells in Nonsegmental Type Vitiligo

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