Reduction of liver enzyme ALT by berberis lycium in acetaminophen induced hepatic damage in mice liver.

Abstract

Objective: The objective of this research was to study the effect of Berberis lyceum (herbal plant) in reduction of liver enzyme ALT in mice. Study Design: Quasi- experimental Study. Setting: Peshawar Medical College, Peshawar. Period: December, 2016 to May, 2017. Materials & Methods: It was an experimental study which was carried out at Peshawar Medical College Warsak Road Peshawar. Total 30 (thirty) mice were used divided in six different groups with five mice in each group. After inducing hepatotoxicity with acetaminophen in the mice, blood samples were taken and LFTs were performed to observe serum ALT values and the effects of different doses of the plant extract were evaluated. Results: The ALT levels of negative control and experimental group were compared and it was shown that ALT levels in experimental groups were 232±42.3, 143±32.5 and 62.2±18.2 whereas serum ALT value of negative control group was 571.4±123.3 which showed that ALT had been decreased by increasing the dose of plant extract. Conclusion: It was concluded that Berberis Lycium, a herbal plant has a potentially active hepato protective role in bringing serum ALT to normal. This plant can be useful in reversing the hepatotoxicity in drug induced elevation of liver enzyme ALT.

Berberis lyceum root bark extract attenuates anticancer drugs induced neurotoxicityand cardiotoxicity in rats

“…Earlier experiments have proved that Berberis lyceum protects against hepatotoxicity by bringing the liver enzymes to their normal levels. 47 Berberine which is an alkaloid present in this plant has the promising effect to reduce oxidative stress and proven beneficial against drug-induced liver toxicity. 48 A study demonstrated that berberine possesses in vivo anti-inflammatory activity and inhibits the activity of activator protein 1, which triggers inflammatory cytokines such as interleukin-6.…”