Reduction of pleural fluid complement activity in patients with systemic lupus erythematosus and rheumatoid arthritis

Glovsky, M. Michael; Louie, James S.; Pitts, William H.; Alenty, A.

doi:10.1016/0090-1229(76)90057-x

Cited by 31 publications

(13 citation statements)

References 25 publications

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“…In 1972, Hunder and associates 22 found low concentration of whole hemolytic complement as well as Clq, C4, and C3 components in SLE pleural fluids when compared with pleural fluids from patients with cancer, heart failure, and other diagnoses. Low pleural fluid complement is not specific for SLE but has also been found in pleural fluid of patients with RA [22][23][24] and patients with empyemas. 23,25 The reduction in complement SLE pleural fluid is evident even after adjustment is made for the total protein content of the pleural fluid.…”

Section: Pleural Changesmentioning

confidence: 99%

Clinical and Pathologic Features of Lung Involvement in Systemic Lupus Erythematosus

Quismorio¹

1988

Semin Respir Crit Care Med

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Section: Pleural Changesmentioning

confidence: 99%

Clinical and Pathologic Features of Lung Involvement in Systemic Lupus Erythematosus

Quismorio¹

1988

Semin Respir Crit Care Med

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“…Reductions in pleural fluid complement levels [4, 43, 44, 72] are helpful in differentiating effusions caused by other connective tissue diseases. However, they are of limited diagnostic value in separating SLE from RA.…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Pleural Involvement in Systemic Autoimmune Disorders

2008

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Systemic autoimmune diseases, a heterogeneous group of immunologically mediated inflammatory disorders including multiorgan involvement, can affect the pleura with various frequencies, either as a single presenting feature or as part of multisystem involvement. Rheumatoid arthritis and systemic lupus erythematosus represent the most common immunological diseases that affect the pleural cavity; however, there is considerable variation regarding the reported prevalence, natural history and prognosis of pleural involvement in both conditions. The definition of pleural disease in the remaining systemic autoimmune disorders is unquestionably imprecise and assumptive, since it is risky to support premises based on single case reports or retrospective data from very small series. In this article, we will review the manifestations of pleural disease caused by rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis/dermatomyositis, mixed connective tissue disease, ankylosing spondylitis, Sjögren’s syndrome and Wegener’s granulomatosis.

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“…One patient had been treated with both prednisone and cyclophosphamide without response. 10 Neither patient, however, had significant pleural effusions. This case report suggests that massive pleural effusions may occur in SLE and prove rather unresponsive to conventional therapy.…”

Section: Discussionmentioning

confidence: 95%

Refractory massive pleural effusion in systemic lupus erythematosus treated with talc poudrage.

Kaine¹

1985

Annals of the Rheumatic Diseases

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Corticosteroid therapy is the mainstay of therapy for symptomatic pleural effusions in SLE. Clinically, patients respond promptly to moderate daily doses of corticosteroids, although occasionally a patient requires several weeks of therapy before radiographic improvement is noted. The purpose of this communication is to report the case of a patient with recurrent massive pleural effusions secondary to active SLE which were unresponsive to corticosteroids, immunosuppressive therapy, and tetracycline

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Reduction of pleural fluid complement activity in patients with systemic lupus erythematosus and rheumatoid arthritis

Cited by 31 publications

References 25 publications

Clinical and Pathologic Features of Lung Involvement in Systemic Lupus Erythematosus

Clinical and Pathologic Features of Lung Involvement in Systemic Lupus Erythematosus

Pleural Involvement in Systemic Autoimmune Disorders

Refractory massive pleural effusion in systemic lupus erythematosus treated with talc poudrage.

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