Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial

Evaluation Anti-Obesity Activity of Psyllium Seeds Powder on Rats Fed a High Fat Diet

“…It binds to bile acids and loses its functions, which prompts the liver to synthesize more bile acids and excrete more cholesterol and LDL-cholesterol, which reduces their concentration in the blood without affecting HDLcholesterol level (good cholesterol). Such findings are in accordance with that observed by González et al (2021) who showed obesity can lead children and adolescents to an increased cardiovascular disease (CVD) risk. A diet supplemented with Plantago psyllium has been shown to be effective in reducing LDL, TG, TC and VLDL but it increases The effects of feeding with psyllium seeds powder on liver function (ALT, AST, ALP and AST/ALT) of normal and obese rats fed on a high-fat diet (HFD):…”

Physiologic Effects of Isolated or Synthetic Dietary Fiber in Children: A Scoping Review

“…Of the 32 studies in the scoping review ( TABLE 4 , TABLE 5 ) [ [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] ], 15 (47%) were parallel RCTs, 15 (47%) crossover RCTs, and 2 (6%) trials with block randomization. Twenty-three studies (72%) were double blinded, 3 (9%) were single blinded, 1 (3%) was nonblinded, and 5 (16%) did not report on this aspect of the study design.…”

“…[ 43 ] 1981 6263076 India G 0.0 Cellulose Low fiber diet Gonzalez et al. [ 44 ] 2021 33861390 Mexico A, I 34.0 Psyllium Rice flour Griffin et al. [ 45 ] 2002 12088517 United States G, I 0.0 Inulin-type fructans Sucrose Gropper and Acosta [ 46 ] 1987 2826563 United States NR 37.5 Combination of isolated fibers Placebo supplement Henao et al.…”

Beneficial effects of psyllium on the prevention and treatment of cardiometabolic diseases

“…133 A recent piece of clinical evidence has demonstrated that psyllium is effective in reducing IL-6 in obese adolescents. 17 Despite this, there was a study that demonstrated that psyllium supplements had no ameliorating effect on CRP levels or other inflammatory markers in overweight or obese individuals. 134 It was the length of the study that may affect the psyllium supplementation intervention.…”

“…10 Recently, psyllium, especially its husk, has been widely used both as a pharmacological supplement and a food product. 11 Pharmacological studies have shown that psyllium exhibits several biopharmacological activities, including against constipation, [12][13][14][15] diarrhea, 15,16 obesity, 17,18 diabetes, [19][20][21][22][23] nonalcoholic fatty liver disease (NAFLD), 24 hypercholesterolemia, 20,[25][26][27][28][29][30] irritable bowel syndrome, 31,32 and colon cancer, 33 some of which are closely related to the development of CMDs. Psyllium husk can be used in food product development, such as in ice cream, bakery goods, dairy and gluten-free products, beverages, chocolates, noodles, and breakfast cereals.…”