Reduction of Urinary Oxalate Excretion in Primary Hyperoxaluria by Diet

Yendt, Edmund R.; Cohanim, M.; Peters, Lawrence

doi:10.1007/978-1-4684-8977-4_65

Cited by 3 publications

(6 citation statements)

References 10 publications

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“…These data are similar to those recently reported by Yendt and Cohanim [15], but are at variance with those obtained by O'Neill et al [22], who found little or no evidence of parathyroid overactivity in their 14 patients with MSK.…”

Section: Discussioncontrasting

confidence: 55%

“…The frequency of radiographic features of MSK may vary from 2.3 to 21 % of patients with calcium stones [6,15,21,22]. We report the incidence of MSK as 7.7% of our patients with recurrent calcium nephrolithiasis.…”

Section: Discussionmentioning

confidence: 86%

“…As an alterna tive hypothesis, MSK might be regarded as an anatomic consequence of idiopathic hypercalciuria. In fact, radiographic findings characteristic of MSK have been ob served in patients with idiopathic hypercalciuria and cal cium nephrolithiasis [6,15,21], regardless of their serum PTH values [22; this report]. Furthermore, nephron dis section [25] showed a striking similarity between intra tubular calcification in collecting ducts of patients with hypercalciuria and with MSK.…”

Section: Discussionmentioning

confidence: 91%

“…Hypercalciuria and recurrent stone for mation are well-known complications of MSK [3]. More over, the association of MSK and parathyroid adenoma has been described in at least 17 patients [6][7][8][9][10][11][12][13][14][15], usually as isolated cases.…”

Section: Introductionmentioning

confidence: 99%

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Medullary Sponge Kidney and Hyperparathyroidism -a Puzzling Association

Maschio

Tessitore

D’Angelo³

et al. 1982

Am J Nephrol

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28 adult patients with radiological evidence of medullary sponge kidney (MSK) were studied. Hypercal-cemia and increased serum parathyroid hormone (PTH) values were found in 10 patients (36%). In 7 of them, parathyroid surgery was performed: a single adenoma was found in 6 cases and multiple-gland hyperplasia in 1 case. After surgery, 3 patients had normalization of calcium metabolism; 4 patients had persistence of hypercalciuria with progressive increase in serum PTH values (and recurrence of the adenoma in 1 case). Of the remaining patients, 10 (36%) had definite or marginal hypercalciuria, resulting from renal calcium leak in 8 and from intestinal calcium hyperabsorption in 2 of them. In 8 patients (28%), no evidence of disordered calcium metabolism was found. The association of MSK and hyperparathyroidism is not a chance occurrence. MSK might be a renal anatomical complication of primary hyperparathyroidism, or it might be regarded as an anatomic substrate – or rather as a consequence -of prolonged hypercalciuria, regardless of its pathogenesis. The lack of disordered calcium metabolism in a considerable number of patients, however, shows that the enigma of MSK is still far from being solved.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Medullary Sponge Kidney and Hyperparathyroidism -a Puzzling Association

Maschio

Tessitore

D’Angelo³

et al. 1982

Am J Nephrol

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“…There are many therapeutic and preventive benefits of avoiding dietary oxalates, including improvements in kidney function 87,88,146,[151][152][153][154] . In addition, both published and unpublished reports suggest benefits such as reversal of neurotoxicity (brain fog, cognition, behavioral and mood disorders, and sleep improvements 155 ), recovery of connective tissue stability 89, 156 and reduced symptoms of autoimmunity 136 .…”

Section: Side-stepping the Trigger/maintenance Processes With Dietmentioning

confidence: 99%

Lost Seasonality and Overconsumption of Plants: Risking Oxalate Toxicity

Norton¹

2017

jevohealth

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In many plants, oxalate crystals are present. These relatively large microcrystals have the potential to inflict mechanical injury. On the other hand, ionic, soluble, and nano-crystal forms of oxalate are readily absorbed. Bioaccumulation in humans is well documented. Crystals and ionic oxalate are associated with pain and both functional and chronic disorders. Today's many health challenges have led people to select foods purported to be healthier, many of which are high in oxalate. Modern dietary approaches have placed great emphasis on the health benefits of vegetables, nuts, and spices. Many of these are high oxalate foods that are now distributed through a global food system in which seasons have been erased, making harm from dietary oxalate more likely now than ever before. Lack of awareness of this potential creates fertile ground for continued increases in human suffering and public health problems.

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Vascular Occlusion and Cardiac Conduction Disturbances in a Patient Undergoing Peritoneal Dialysis

Kay

1993

Seminars in Dialysis

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A 46-year-old woman, who had previously been well, developed nausea, vomiting, and anorexia in May 199 1. Her medical history was remarkable only for arthritis involving the knees and the proximal interphalangeal joints of the hands, which was treated for 2 years with ibuprofen and hydroxychloroquine sulfate while she was in her twenties. Her family history was remarkable for a sister who died at age 5 of "nephritis." Twin brothers both had chronic renal failure caused by primary oxalosis. One had died at age 29 of myocardial infarction and the other at age 34 of complications of gangrene. Neither parent had been diagnosed with renal disease, and both died in their sixties of myocardial infarction. The patient had no children. Laboratory studies revealed a hematocrit of 26.6%, a BUN of 124 mg/dl, a serum creatinine of 11.2 mg/dl, a serum calcium of 9.2 mg/dl, and a serum phosphate of 7.9 mg/dl. Liver function studies were normal. Urinalysis revealed proteinuria and pyuria without crystals or casts. A 24-hour urine collection revealed normal urinary oxalate excretion. Both kidneys were small and hyperechoic on ultrasonographic examination. Extensive evaluation revealed no clear cause for renal failure. A Tenckhoff catheter was placed, and maintenance peritoneal dialysis was initiated in July 199 1 for uremic symptoms. A regimen of calcium carbonate, erythropoietin, and Nephrocaps was begun.Shortly after beginning peritoneal dialysis, the patient noticed transient episodes in which her fingertips became cyanotic, painful, and cool to the touch for periods of about 10 minutes. Subsequently, transient mottling of the skin on her legs developed. She also noted the onset of calf pain when walking. The frequency of these episodes increased over the course of 1 month, and she was referred for rheumatological evaluation.On examination, livedo reticularis was present on both lower legs. The fingers were cool to the touch, and the toes were cyanotic. Joint deformities and signs of inflammation were absent. The arterial pulses were normal in both upper extremities and in both femoral arteries: however, the popliteal, posterior tibial, and dorsalis pedis arterial pulses were very weak bilaterally. No bruits were audible. Laboratory studies revealed an erythrocyte sedimentation rate of 75 mm/hr, cholesterol of 240 mg/dl, and triglycerides of 176 mg/dl. Antinuclear antibodies, rheumatoid factor, and cryoglobulins were absent. The CH50 was slightly elevated to 276, and levels of Clq, C3, and C4 were normal. Serum oxalate was 99 mmol/L (normal, <6 mmol/L). Biopsies of the skin on both lower legs demonstrated deposition of calcium oxalate crystals within the lumina and muscular walls of the subcutaneous arteries (Fig. 1). No evidence of vasculitis or cholesterol emboli was found.Aortography demonstrated narrowing of the left anterior tibial and right distal popliteal arteries and occlusion of both posterior tibial arteries at or near their origins. There was collateral blood flow to both ankles.Treatment with 10 mg oral nifedipine...

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Reduction of Urinary Oxalate Excretion in Primary Hyperoxaluria by Diet

Cited by 3 publications

References 10 publications

Medullary Sponge Kidney and Hyperparathyroidism -a Puzzling Association

Medullary Sponge Kidney and Hyperparathyroidism -a Puzzling Association

Lost Seasonality and Overconsumption of Plants: Risking Oxalate Toxicity

Vascular Occlusion and Cardiac Conduction Disturbances in a Patient Undergoing Peritoneal Dialysis

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