Reduction sensitive hyaluronan-SS-poly(ε-caprolactone) block copolymers as theranostic nanocarriers for tumor diagnosis and treatment

Yang, Huiting; Wang, Nianhua; Mo, Lei; Wu, Mei; Yang, Ruimeng; Xu, Xiangdong; Huang, Yugang; Lin, Jiantao; Zhang, Liming; Jiang, Xinqing

doi:10.1016/j.msec.2018.12.132

Cited by 31 publications

(22 citation statements)

References 30 publications

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“…The drug distribution in the tumor of the BTZ-NP group was statistically higher than the BTZ solution group. The superior enrichment of the BTZ-NP in the malignant tissue was ascribed to the EPR effects of the nano-drug delivery systems and, would promise profound therapeutic effects [16][17][18][19][20][21][22][23][24].…”

Section: In Vivo Distribution Of the Btz-npmentioning

confidence: 99%

Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles

et al. 2020

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Backgrounds: Intolerable toxicity and unsatisfactory therapeutic effects are still big problems retarding the use of chemotherapy against cancer. Nano-drug delivery system promised a lot in increasing the patients' compliance and therapeutic efficacy. As a unique nano-carrier, supermolecular aggregation nanovehicle has attracted increasing interests due to the following advantages: announcing drug loading efficacy, pronouncing in vivo performance and simplified production process. Methods: In this study, the supermolecular aggregation nanovehicle of bortezomib (BTZ) was prepared to treat breast cancer. Results: Although many supermolecular nanovehicles are inclined to disintegrate due to the weak intermolecular interactions among the components, the BTZ supermolecules are satisfying stable. To shed light on the reasons behind this, the forces driving the formation of the nanovehicles were detailed investigated. In other words, the interactions among BTZ and other two components were studied to characterize the nanovehicles and ensure its stability. Conclusions: Due to the promising tumor targeting ability of the BTZ nanovehicles, the supermolecule displayed promising tumor curing effects and negligible systemic toxicity.

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Section: In Vivo Distribution Of the Btz-npmentioning

confidence: 99%

Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles

et al. 2020

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“…The safety of prodrug was determined after 24 and 72 h of incubation with a series of Hep-Chl concentrations (0, 0.2, 0.4, 0.6, 0.8, and 1 mg/mL equivalent concentration of Chl), which revealed no potential cytotoxicity of the Hep-Chl prodrug nanoparticles against HaCaT and RAW264.7 cells at a maximum dose of 1 mg/mL. This may be attributed to the lower level of GSH and H 2 O 2 and thereby insufficient cleavage of Chl from the Hep-Chl prodrug in normal cells [37][38][39][40] (Figure 6). In contrast, the viability of HeLa cells treated with Hep-Chl prodrug nanoparticles with the same concentrations was decreased to 41% at 24 h and 23% at 72 h treatments with increase in concentration ( Figure S4a), which was considerably lower than that of RAW264.7 cells treated with the same concentration of the prodrug ( Figure S4b).…”

Section: In Vitro Cytotoxicity Studymentioning

confidence: 98%

“…Under normal conditions without any stimuli, the cumulative release of Chl was below 30% within 72 h, suggesting that the release of Chl from the prodrugs without redox stimuli was below 30%. However, the cumulative release of Chl in the redox stimuli in PBS containing 6 mM GSH and 0.1% H 2 O 2 was found to be faster, and 75% and 85% of Chl was released, respectively, within 72 h. Both bioactive drugs, Hep and Chl, were covalently linked to each other by disulfide bonds, which could be cleaved to activate Hep and Chl through a reducing agent GSH and an oxidizing agent H 2 O 2 [36][37][38]. Overall, this stimuli-responsive prodrug-based delivery system could facilitate the accumulation of drugs in tumor tissues and improve cancer therapeutic efficacy [14].…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 98%

Redox-Responsive Heparin–Chlorambucil Conjugate Polymeric Prodrug for Improved Anti-Tumor Activity

et al. 2019

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Polymeric prodrug-based delivery systems have been extensively studied to find a better solution for the limitations of a single drug and to improve the therapeutic and pharmacodynamics properties of chemotherapeutic agents, which can lead to efficient therapy. In this study, redox-responsive disulfide bond-containing amphiphilic heparin–chlorambucil conjugated polymeric prodrugs were designed and synthesized to enhance anti-tumor activities of chlorambucil. The conjugated prodrug could be self-assembled to form spherical vesicles with 61.33% chlorambucil grafting efficiency. The cell viability test results showed that the prodrug was biocompatible with normal cells (HaCaT) and that it selectively killed tumor cells (HeLa cells). The uptake of prodrugs by HeLa cells increased with time. Therefore, the designed prodrugs can be a better alternative as delivery vehicles for the chlorambucil controlled release in cancer cells.

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“…The loading efficiency of retinal/indocyanine green was recorded to be 9.23%, indicating its outstanding loading capacity. Amphiphilic hyaluronan-SS-poly(ε-caprolactone) diblock copolymers (HA-SS-PCL) were developed and employed as multifunctional nanocarriers for the diagnosis and management of tumor nanocarriers [ 281 ]. On one hand, HA shells containing theranostic nanoparticles possessed a higher affinity to CD44 expressed on the surface of malignant cells, leading to the accumulation of elevated levels of drugs.…”

Section: Stimuli-responsive Polymeric Nanocarriers For Theranosismentioning

confidence: 99%

“…Cell apoptosis and MTT assay revealed prominent anticancer activity of the DOX-bearing HA-SS-PCL micelles against HepG2 cells compared to the reduction-insensitive HA-PCL micelles under identical conditions. Thus, the newly developed HA-SS-PCL block copolymers presented promise as versatile, tumor-targeting theranostic nanocarriers [ 281 ]. Shao et al (2019) utilized polymer-based micelles to control indocyanine green (ICG) J-aggregation in a highly effective and rapid way.…”

Section: Stimuli-responsive Polymeric Nanocarriers For Theranosismentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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Reduction sensitive hyaluronan-SS-poly(ε-caprolactone) block copolymers as theranostic nanocarriers for tumor diagnosis and treatment

Cited by 31 publications

References 30 publications

Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles

Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles

Redox-Responsive Heparin–Chlorambucil Conjugate Polymeric Prodrug for Improved Anti-Tumor Activity

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

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