Reelin is expressed in the accessory olfactory system, but is not a guidance cue for vomeronasal axons

Teillon, Sarah; Yiu, Glenn; Walsh, Christopher A.

doi:10.1016/s0165-3806(02)00616-8

Cited by 16 publications

(15 citation statements)

References 14 publications

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“…It is now well established that neurotrophic factors such as brain-derived neurotrophic factor (BDNF), NGF, glial cell line-derived neurotrophic factor (GDNF) expressed in pulp tissue are suspected to be involved in the control of pulpal axon growth (Naftel et al, 1994;Luuko et al, 1997;Nosrat et al, 1998Nosrat et al, , 2001, such as semaphorins (3A) recently identified in developing mouse teeth (Loes et al, 2001) and in fully differentiated odontoblasts in vitro (personal data). In these conditions, the role of reelin could be restricted to the extension and branching of pulp axons in terminal fields as described in other tissues (Borrell et al, 1999;Carroll et al, 2001;Jossin and Goffinet, 2001;Teillon et al, 2003). Interestingly, our in vitro findings showed that reelin detected in the Golgi region is closely associated with the odontoblast cell membrane as a tenuous extracellular veil supporting the hypothesis previously raised (Alcantara et al, 1998) that reelin is too large to diffuse.…”

Section: Discussionsupporting

confidence: 87%

Expression and localization of reelin in human odontoblasts

Maurin¹,

Couble²,

Didier-Bazes

et al. 2004

Matrix Biology

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Section: Discussionsupporting

confidence: 87%

Expression and localization of reelin in human odontoblasts

Maurin¹,

Couble²,

Didier-Bazes

et al. 2004

Matrix Biology

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“…6A-D,G,H). However, sections from the same animals stained with an antibody against peripherin in order to visualize the cVNN associated with migrating GnRH neurons, showed that, in agreement with a recent report (Teillon et al, 2003), there was no anomaly in the pattern of cVNN fibres (data not shown).…”

Section: Gnrh Neurons In Reeler Scrambler and Reelin Receptor Mutantsupporting

confidence: 90%

“…Previous studies have demonstrated the abundant presence of reelin at various levels of rodent olfactory system (Ikeda and Terashima, 1997;Alcantara et al, 1998;Teillon et al, 2003). Specifically, strong reelin expression has been detected in the olfactory epithelium, main and accessory olfactory bulb, vomeronasal organ and VNN.…”

Section: Resultsmentioning

confidence: 94%

“…It has also been found to have important roles in a number of developmental events in the hippocampus (Del Rio et al, 1997;Niu et al, 2004;Zhao et al, 2004) and other areas of the CNS (Lambert de Rouvroit and Goffinet, 1998), and has been implicated in the migration of autonomic neurons in the spinal cord (Yip et al, 2000). Reelin is highly expressed in the olfactory system, including the olfactory bulb, vomeronasal organ and VNN (Ikeda and Terashima, 1997;Alcantara et al, 1998;Teillon et al, 2003), and investigators have recently queried its role in this system. Here, we tested the hypothesis that reelin acts as a guidance signal for the migration of GnRH neurons and their disposition in the forebrain.…”

Section: Introductionmentioning

confidence: 99%

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Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neurons

et al. 2005

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Gonadotropin-releasing hormone (GnRH) neurons, a small number of cells scattered in the hypothalamic region of the basal forebrain, play an important role in reproductive function. These cells originate in the olfactory placode and migrate into the basal forebrain in late embryonic life. Here, we show that reelin, which is expressed along the route of the migrating cells, has an inhibitory role in guiding GnRH neurons to the basal forebrain. Only a small(approximately 5%) subpopulation of these neurons expresses one of the reelin receptors (ApoER2/Lrp8), and all GnRH neurons appear to lack the intracellular adaptor protein Dab1, suggesting that the function of reelin is not mediated by the conventional signal transduction pathway. The importance of reelin in the establishment of GnRH neurons in the hypothalamus was confirmed by our finding that the brains of developing and adult reeler mice of both sexes contained a markedly reduced number of these neuroendocrine neurons. Furthermore, the testes of adult males showed dilation of seminiferous tubules and reduction in their density when compared with controls. Mutants lacking the reelin receptors ApoER2 and Vldlr, and scrambler mice lacking Dab1, showed a normal complement of GnRH neurons in the hypothalamus,confirming that the effect of reelin in their migration is independent of Dab1.

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“…In fact, as mentioned above, it has been shown previously that Reelin is involved in the regulation of axonal growth in the hippocampus (Del Río et al 1997;Borrell et al 1999a;Borrell et al 2007). For a subset of vomeronasal axons, however, it was reported that their axonal trajectory did not appear to be altered in so-called reeler mice, in which the Reelin-encoding gene is deficient; this finding has led to speculations that Reelin does not affect axonal pathfinding in the olfactory system (Teillon et al 2003). In this context, it has to be pointed out that the pathfinding of olfactory axons is presumably regulated by multiple factors, including other ECM proteins, such as laminin and type-IV collagen (Rogers et al 1986;Riggott and Moody 1987;Gong and Shipley 1996;Treloar et al 1996;Whitesides andLaMantia 1996, Julliard andHartmann 1998;reviewed by Balmer and LaMantia 2005).…”

Section: Discussionmentioning

confidence: 93%

Outgrowing olfactory axons contain the Reelin receptor VLDLR and navigate through the Reelin-rich cribriform mesenchyme

2009

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Chemosensory neurons in the olfactory epithelium (OE) project axonal processes to the olfactory bulb (OB) of the brain. During embryonic stages, on their trajectory to the OB, the outgrowing axons traverse the so-called cribriform mesenchyme, which is located between the OE and the OB. The molecular cues guiding these axons through the cribriform mesenchyme are largely unknown. To identify molecules influencing the axonal trajectory in the murine cribriform mesenchyme, we performed microarray analyses focusing on extracellular matrix (ECM) proteins present in this tissue. Thereby, the ECM protein Reelin turned out to be an interesting candidate. Reelin was found to be expressed by numerous cells in the cribriform mesenchyme during the embryonic stages when the first axons navigate from the OE to the OB. These cells were closely associated with olfactory axons and apparently lack glial and neuronal markers. In the mesenchyme underlying the OE, localization of the Reelin protein was not confined to the Reelin-expressing cells, but it was also observed to be widely distributed in the ECM-most prominently in regions traversed by olfactory axons. Importantly, these axons were found to be endowed with the Reelin receptor very-low-density lipoprotein receptor (VLDLR). Finally, Reelin expression was also detectable in neuronal cells of the OB, which are contacted by VLDLR-positive olfactory axons. In summary, the results of the present study suggest that a Reelin/VLDLR signaling pathway might contribute to the formation of olfactory projections to the OB and the establishment of initial contacts between the incoming axons and neurons in the OB.

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Reelin is expressed in the accessory olfactory system, but is not a guidance cue for vomeronasal axons

Cited by 16 publications

References 14 publications

Expression and localization of reelin in human odontoblasts

Expression and localization of reelin in human odontoblasts

Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neurons

Outgrowing olfactory axons contain the Reelin receptor VLDLR and navigate through the Reelin-rich cribriform mesenchyme

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